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1,421 Possible Causes for Long Bone Fracture

  • Primary Hyperparathyroidism

    Finally, pathological bone fractures due to Osteitis Fibrosa Cystica, described, above or accelerated osteoporosis is a common feature of untreated disease.[pathwaymedicine.org] […] and explain further the increased risk of fractures at both cortical and trabecular skeletal sites.[ncbi.nlm.nih.gov] Thin long bones bend under the stress of weight bearing. Intervertebral disks become ballooned as they indent soft vertebral bodies.[boneandspine.com]

  • Langerhans-Cell Histiocytosis

    The granulomas, which usually occur in the skull or the long bones of the arms or legs, may cause the bone to fracture.[ghr.nlm.nih.gov] Bone: Skull is most commonly affected followed by long bones of upper extremities and flat bones. Painful swelling of bones is common.[symptoma.com] Other complications include fractures of long bones and compression of vertebrae causing extreme pain and possibly spinal cord damage.[rarediseases.org]

  • Purtscher's Retinopathy

    A similar retinopathy has been reported in compressive chest trauma, long bone fractures, and acute pancreatitis.[ncbi.nlm.nih.gov] Purtscher's retinopathy is a sight threatening, occlusive microvasculopathy associated with trauma, it is rarely reported after long bone fractures.[ncbi.nlm.nih.gov] Purtscher's retinopathy may be caused by extensive fractures of the long bones.[en.wikipedia.org]

  • Fracture

    Classification (OTA-OFC) AO Pediatric Comprehensive Classification of Long Bone Fractures (PCCF) Appendix To view the OTA/AO Fracture and Dislocation Classification Compendium[ota.org] The fractures are most commonly transverse in nature, occurring in the shafts of the long bones.[pediatrics.aappublications.org] Tibia fracture Fracture of the tibia is the most common long bone fracture injury and can take a long time to recover from.[sportsinjuryclinic.net]

  • Maffucci Syndrome

    Bone irregularities in Maffucci syndrome include shortened length of the long bones, unequal leg length, pathologic fractures, and malunion of fractures. [10] In Maffucci[emedicine.com] They can appear anywhere, but they usually are found on the phalanges and the long bones.[emedicine.com] These bone abnormalities usually are asymmetric and can cause secondary fractures. Approximately 30-37% of enchondromas develop into a chondrosarcoma.[emedicine.com]

  • Paget Disease of the Bone

    May see fractures in long bones affected by disease Diagnosis and treatment Control osteoclastic activity Diphosphonates Calcitonin Methotrexate[orthopaedicsone.com] Comminuted: Bone completely broken in a transverse, spiral or oblique direction ( indicates the direction of the fracture in relation to the long axis of the fracture bone[slideplayer.com] […] are most typically found in the skull, spine, pelvis and long bones of the lower extremities.[books.google.com]

  • Dyskeratosis Congenita

    Abstract Dyskeratosis congenita (DC) is a genetic disorder of defective tissue maintenance and cancer predisposition caused by short telomeres and impaired stem cell function. Telomerase mutations are thought to precipitate DC by reducing either the catalytic activity or the overall levels of the telomerase[…][ncbi.nlm.nih.gov]

  • Osteogenesis Imperfecta Type 2

    As type I collagen is reduced in the bone matrix, many long-bone fractures can occur while the degree of fragility of the bone and the rate of fracture rate may vary significantly[news-medical.net] Patients with type II present multiple rib and long bone fractures at birth, marked deformities, broad long bones, low density on skull X-rays, and dark sclera.[rarediseases.info.nih.gov] , low bone mass and susceptibility to bone fractures.[orpha.net]

  • Osteogenesis Imperfecta

    Bisphosphonate treatment decreases long-bone fracture rates, but such fractures are still frequent.[ncbi.nlm.nih.gov] Patients with type II present multiple rib and long bone fractures at birth, marked deformities, broad long bones, low density on skull X-rays, and dark sclera.[orpha.net] However, bisphosphonates are less effective for preventing long-bone fractures. At the moment, new therapies are under investigation.[ncbi.nlm.nih.gov]

  • Osteogenesis Imperfecta Type 3

    Clinical examinations revealed low bone density, short stature, severe vertebral compression fractures, and multiple long bone fractures in the affected members.[ncbi.nlm.nih.gov] Phenotypic characteristics include defective cranial ossification and severe skeletal deformity due to intrauterine rib and long bone fractures.[jhu.pure.elsevier.com] As type I collagen is reduced in the bone matrix, many long-bone fractures can occur while the degree of fragility of the bone and the rate of fracture rate may vary significantly[news-medical.net]

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