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324 Possible Causes for Long Tract Signs, Progressive Disease

  • Primary Progressive Multiple Sclerosis

    The majority of patients starts with relapsing remitting (RR) disease; approximately 50-60% of these patients progress to secondary progressive (SP) disease.[ncbi.nlm.nih.gov] METHODS: A systematic literature research was performed to identify predictors for disease progression in PPMS.[ncbi.nlm.nih.gov] Only about 15% of the patients develop a progressive disease course from onset, termed primary progressive multiple sclerosis (PPMS); the underlying pathogenic mechanisms[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    This review examined current research related to moderate exercise for maintaining independence without accelerating disease progression in persons with ALS.[ncbi.nlm.nih.gov] , often asymmetrical); seldom significant long tract signs unless foramen magnum involved in addition MRI; CT with bone windows; no EMG evidence of CPD in limbs unless wasting[doi.org] PMID: 19556916 Issn Print: 1557-0576 Publication Date: 2009/06/01 Checking for direct PDF access through Ovid Abstract Amyotrophic lateral sclerosis (ALS) is an idiopathic disease[doi.org]

  • Alzheimer Disease

    BACKGROUND AND OBJECTIVE: Semantic memory measures may be useful in tracking and predicting progression of Alzheimer disease.[ncbi.nlm.nih.gov] Alzheimer’s is a progressive disease. This means that gradually, over time, more parts of the brain are damaged.[alzheimers.org.uk] There are some drug treatments for Alzheimer’s disease that can help boost the levels of some chemical messengers in the brain. This can help with some of the symptoms.[alzheimers.org.uk]

  • Metachromatic Leukodystrophy

    Seizures occur with the advanced disease. Progression to death occurs about six years after the onset of symptoms.[symptoma.com] This may be due to the progressive disease in MLD.[ncbi.nlm.nih.gov] Serial MR imaging studies in 6 patients showed significant progressive disease in 3 patients (initial score average, 4; mean follow-up, 24.3) and no change or 1 point progression[ncbi.nlm.nih.gov]

  • Multiple Sclerosis

    The disease course of progressive MS is characterised by the build-up of neurologic disability (the loss of some bodily or mental functions) with or without relapses.[msif.org] […] may occur in the absence of inflammation, particularly in patients with progressive disease.[itunes.apple.com] […] the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive[ncbi.nlm.nih.gov]

  • Diffuse Cerebral Sclerosis of Schilder

    Serial MR imaging, positive for adrenoleukodystrophy in 34 patients (mean follow-up, 23 months; range, 2 months to 6 years 11 months), showed progressive disease in 52%, progressive[ajnr.org] , a slowly progressive disease of the spinal cord, or both.[doi.org] Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease.[ncbi.nlm.nih.gov]

  • Spastic Paraplegia

    Nothing is known about longevity but spastic paraplegia is a progressive disease leading to increasing disability.[disorders.eyes.arizona.edu] tract signs, facial dysmorphism and adducted thumbs.[ncbi.nlm.nih.gov] Synonym(s): progressive muscular dystrophy Erb disease - progressive weakness and atrophy of the muscles of the tongue, lips, palate, pharynx, and larynx, most often caused[medical-dictionary.thefreedictionary.com]

  • Spinocerebellar Ataxia Type 1

    Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease caused by a gene defect, leading to movement disorder such as cerebellar ataxia.[ncbi.nlm.nih.gov] Finally, in all different models examined glial activation closely correlated with disease progression, supporting the development of glial-based biomarkers to follow disease[ncbi.nlm.nih.gov] The present pilot work represents an initial effort describing connectivity biomarkers of disease progression in SCA1.[ncbi.nlm.nih.gov]

  • Myelopathy

    Nonoperative Management Unfortunately, symptomatic myelopathy is a progressive disease resulting in irreversible damage of the spinal cord, and is thus considered a surgical[coloradospineinstitute.com] Physical examination commonly elicits long tract signs such as spasticity, hyperreflexia, and abnormal reflexes such as Babinski or Hoffman's sign.[neurosurgery.ucla.edu] Some patients suffer from mild disease over prolonged periods of time. In others, CSM causes progressive paralysis.[web.archive.org]

  • Malignant Glioma

    The patient is a young adult with recurrent progressive disease refractory to aggressive multi-modality therapy including repetitive surgical resection, radiation, radiosurgery[ncbi.nlm.nih.gov] With pontine and cervicomedullary lesions, cranial nerve or long tract signs are observed commonly.[emedicine.medscape.com] The aim of this study was to evaluate the outcome for all patients with progressive disease treated with bevacizumab-based treatment combinations in the northern region of[ncbi.nlm.nih.gov]

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