Create issue ticket

455 Possible Causes for Loss of Ambulation between Third and Sixth Decade, Persistent Notochordal Canal, Stiffness of the Lower Limbs

  • Limb-Girdle Muscular Dystrophy Type 2J

    notochordal canal syndrome Salla disease Salt-and-pepper syndrome Sandhoff disease Sandhoff disease, adult form Sandhoff disease, infantile form Sandhoff disease, juvenile[se-atlas.de] […] syndrome SLC35A1-CDG SLC35A2-CDG SSR4-CDG STT3A-CDG STT3B-CDG SURF1-related Charcot-Marie-Tooth disease type 4 Sacral agenesis-abnormal ossification of the vertebral bodies-persistent[se-atlas.de]

    Missing: Stiffness of the Lower Limbs
  • Infantile-Onset Ascending Hereditary Spastic Paralysis

    These disorders are characterized by muscle stiffness (spasticity) and weakness in the lower limbs (paraplegia).[icdlist.com] notochordal canal syndrome Salla disease Salt-and-pepper syndrome Sandhoff disease Sandhoff disease, adult form Sandhoff disease, infantile form Sandhoff disease, juvenile[se-atlas.de] These disorders are characterized by progressive muscle stiffness (spasticity) and eventual paralysis of the lower limbs (paraplegia).[ghr.nlm.nih.gov]

    Missing: Loss of Ambulation between Third and Sixth Decade
  • Arthritis

    Because there are several types of arthritis, it’s important to know which one you have. There are some similarities between these conditions, but there are also some key differences. Osteoarthritis The most common type of arthritis is osteoarthritis. It is estimated that around 8.75 million people in the UK have[…][arthritisresearchuk.org]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Meningomyelocele

    This can result in numbness, unbalanced walking, painless skin lesions, stiffness and pain in the lower limbs and back, sometimes relieved with odd postures or lying down.[amardeepchildrenhospital.com] […] splits around that adhesion or persistence of the neurenteric canal, which would leave a connection of pluripotent cells between the ectoderm and the endoderm. [8] The role[asianjns.org] […] theories postulated are neoplastic transformation of misplaced primordial germ cells from the yolk sac, an ectodermal-to-endodermal adhesion forms during gastrulation and the notochord[asianjns.org]

    Missing: Loss of Ambulation between Third and Sixth Decade
  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Weakness progresses to the forearms, shoulders, and lower limbs.[msdmanuals.com] notochordal canal syndrome Salla disease Salt-and-pepper syndrome Sandhoff disease Sandhoff disease, adult form Sandhoff disease, infantile form Sandhoff disease, juvenile[se-atlas.de] When upper motor neurons are affected the manifestations include spasticity or stiffness of limb muscles and overactivity of tendon reflexes such as knee and ankle jerks.[advancedpsy.com]

    Missing: Loss of Ambulation between Third and Sixth Decade
  • Congenital Malformation of the Spine

    Neurological assessment revealed myelopathic gait with bilateral upper limb and lower limb hyperreflexia, bilateral Babinski sign and Hoffman’s reflex present.[jss.amegroups.com] Around the third week of gestation, when the cells from Hensen’s node are proliferating and migrating, there may be a focal splitting of the notochord secondary to a persistent[radiologykey.com] There was no history of trauma, any joint stiffness, fever, weight loss or stigmata of tuberculosis.[jss.amegroups.com]

    Missing: Loss of Ambulation between Third and Sixth Decade
  • Neonatal Adrenoleukodystrophy

    Symptoms may include progressive stiffness, weakness, or paralysis of the lower limbs and loss of coordination. Brain function deterioration may also been seen.[medical-dictionary.thefreedictionary.com] Adult-onset symptoms, which usually develop between the ages of 21 and 35, may include progressive stiffness, weakness or paralysis of the lower limbs, and loss of coordination[simplygoodnaturalfoods.com]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Polymyalgia Rheumatica

    INTRODUCTION Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are linked inflammatory conditions that affect different parts of the body. They are frequently discussed together because: Polymyalgia rheumatica occurs in about 50 percent of people with giant cell arteritis. Approximately 15 to 30 percent[…][web.archive.org]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Spinal Stenosis

    Spinal stenosis Spinal stenosis Specialty Orthopedics, neurosurgery Symptoms Pain, numbness, or weakness in the arms or legs [1] Complications Loss of bladder control, loss of bowel control, sexual dysfunction [1] Usual onset Gradual [1] Types Cervical, thoracic, lumbar [2] Causes Osteoarthritis, rheumatoid arthritis,[…][en.wikipedia.org]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Lumbar Osteoarthritis

    Pain on weight-bearing if the lower limb joints are involved.[arthritis.co.za] It can occur in any joint, but is most commonly seen in selected joints of the hand, spine, and lower limb.[bmcmusculoskeletdisord.biomedcentral.com] Stiffness after rest - called gelling - usually lasting less than 5 minutes - with the patient loosening up quickly by moving the joints.[arthritis.co.za]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal