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217 Possible Causes for Loss of Ambulation between Third and Sixth Decade, Persistent Notochordal Canal, Upper and Lower Motor Neuron Degeneration

  • Infantile-Onset Ascending Hereditary Spastic Paralysis

    […] of the upper motor neurons whereas infantile-onset spastic paralysis is more severe and involves degeneration of upper and lower motor neurons Symptoms - Hereditary spastic[checkorphan.org] notochordal canal syndrome Salla disease Salt-and-pepper syndrome Sandhoff disease Sandhoff disease, adult form Sandhoff disease, infantile form Sandhoff disease, juvenile[se-atlas.de] ALS2, JPLS and IAHSP are progressive disabling disorders that result from dysfunction of upper motor neurons (UMN) or affection of lower motor neurons (LMN).[deepdyve.com]

    Missing: Loss of Ambulation between Third and Sixth Decade
  • Limb-Girdle Muscular Dystrophy Type 2J

    notochordal canal syndrome Salla disease Salt-and-pepper syndrome Sandhoff disease Sandhoff disease, adult form Sandhoff disease, infantile form Sandhoff disease, juvenile[se-atlas.de] […] syndrome SLC35A1-CDG SLC35A2-CDG SSR4-CDG STT3A-CDG STT3B-CDG SURF1-related Charcot-Marie-Tooth disease type 4 Sacral agenesis-abnormal ossification of the vertebral bodies-persistent[se-atlas.de]

    Missing: Upper and Lower Motor Neuron Degeneration
  • Upper Motor Neuron Disease

    Motor Neurone Disease Motor Neurone Disease (MND) is a progressive neurodegenerative disease that attacks the upper and lower motor neurones .[bournemouthphysiotherapy.co.uk] This has been observed in patients with genetic mutations and clear-cut pathological evidence of upper and lower motor neuron degeneration.[academic.oup.com] Focality of upper and lower motor neuron degeneration at the clinical onset of ALS. Neurology 2007;68:1571-5. Ravits JM, La Spada AR.[acnr.co.uk]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Upper motor neuron degeneration generally causes spasticity (tightness in a muscle), slowness of movement, poor balance and incoordination, while lower motor neuron degeneration[mda.org] notochordal canal syndrome Salla disease Salt-and-pepper syndrome Sandhoff disease Sandhoff disease, adult form Sandhoff disease, infantile form Sandhoff disease, juvenile[se-atlas.de] In amyotrophic lateral sclerosis there is involvement of upper, lower, and brainstem motor neurons.[icd10data.com]

    Missing: Loss of Ambulation between Third and Sixth Decade
  • Amyotrophic Lateral Sclerosis Type 6

    Those criteria are as follows: Clinical evidence of upper motor neuron degeneration Clinical, electrophysiological, or neuropathological evidence of lower motor neuron degeneration[symptoma.com] In ALS, both the upper motor neurons and the lower motor neurons degenerate or die, and stop sending messages to the muscles.[ninds.nih.gov] neurons) and from the spinal cord and motor nuclei of brain to a particular muscle or muscles.[ninds.nih.gov]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Amyotrophic Lateral Sclerosis Type 5

    Juvenile onset ALS is a very rare form of motor neuron disease, with the first symptoms of upper and lower motor neuron degeneration manifested before 25 years of age.[atm.amegroups.com] Usually, patients present with upper motor neuron (UMN) and lower motor neuron compromise.[pediatricneurosciences.com] The degeneration of upper and lower motor neurons gradually weakens the muscles they control, leading to paralysis and eventual death from respiratory failure.[sciencedaily.com]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Amyotrophic Lateral Sclerosis Type 1

    Diagnosis Amyotrophic lateral sclerosis is characterized by degeneration of both the upper and lower motor neurons.[rarediseases.org] Clinical Significance: ALS is characterized by progressive degeneration of upper and lower motor neurons leading to muscle stiffness, fasciculations, and atrophy.[athenadiagnostics.com] El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis 7 : it requires the presence of signs of lower motor neuron (LMN) degeneration by clinical, electrophysiological[radiopaedia.org]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Amyotrophic Lateral Sclerosis

    Abstract Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disorder, characterized by the selective degeneration of upper and lower motor neurons.[ncbi.nlm.nih.gov] […] in degenerating lower motor neurones.[ncbi.nlm.nih.gov] ALS causes both the upper and lower motor neurons to degenerate or die.[web.archive.org]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Amyotrophic Lateral Sclerosis Type 11

    Those criteria are as follows: Clinical evidence of upper motor neuron degeneration Clinical, electrophysiological, or neuropathological evidence of lower motor neuron degeneration[symptoma.com]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal
  • Motor Neuron Disease

    Slowly upper and lower motor neuron degeneration, even with non-motor clinical features, should prompt a sequencing of SOD1.[ncbi.nlm.nih.gov] The patients also showed clinical and electrophysiological signs of upper and/or lower motor neuron degeneration.[ncbi.nlm.nih.gov] neuron (LMN) degeneration.[ncbi.nlm.nih.gov]

    Missing: Loss of Ambulation between Third and Sixth Decade Persistent Notochordal Canal