Loss of Anterior Horn Cells: Causes & Reasons

Possible Causes for Loss of Anterior Horn Cells

The disorder is characterized by degeneration and loss of anterior horn cells in the spinal cord and sometimes also in the brainstem, leading to symmetrical muscle weakness [accessanesthesiology.mhmedical.com]

In pathologic terms, the disease was characterized by loss of anterior horn cells. [emedicine.medscape.com]

Just skip this one for now. 1 Progressive replacement of muscle tissue with fibrous and fatty tissue, causing calf pseudohypertrophy 2 Loss of anterior horn cells and progressive [orthobullets.com]

Spinal Muscular Atrophy Type 3

It is characterized by progressive degeneration and loss of the anterior horn cells in the spinal cord and brain stem. [unimd.org]

In pathologic terms, the disease was characterized by loss of anterior horn cells. [emedicine.medscape.com]

The central role of lower motor neuron degeneration was confirmed in subsequent pathologic studies demonstrating a loss of anterior horn cells in the spinal cord and cranial [emedicine.medscape.com]

Distal Spinal Muscular Atrophy Type 1

[…] of anterior horn cells in the spinal cord and brain stem nuclei. [avicennajmed.com]

In pathologic terms, the disease was characterized by loss of anterior horn cells. [emedicine.medscape.com]

Figure 1 Anterior horn, possible nerve cell loss (subtle) and slight reactive gliosis. Photo David Schei Figure 2 Medulla spinalis, thin anterior root (top left). [tidsskriftet.no]

Spinal Muscular Atrophy Type 4

In pathologic terms, the disease was characterized by loss of anterior horn cells. [emedicine.medscape.com]

[…] of anterior horn cell function. [neurologyindia.com]

Amyotrophic Lateral Sclerosis Type 4

Microscopic examination demonstrated marked loss of anterior horn cells, the few remaining neurons appearing shrunken (Fig. 3A–C ). [academic.oup.com]

A progressive motor neuron disorder characterized by involvement of anterior horn cells of spinal cord. [orthobullets.com]

horn cells Shrinkage & Loss of cell bodies Course of cell body loss 22 Early: Rapid Late: Slower ? [neuromuscular.wustl.edu]

X-linked Distal Spinal Muscular Atrophy Type 3

[…] of anterior horn cells and death in infancy. [nature.com]

anterior horn cells with secondary muscle loss and weakness. [ncbi.nlm.nih.gov]

[…] of innervation to the muscle Can be due to radiculopathy from tumor, cyst or herniated nucleus pulposus Other causes are loss of the anterior horn cell in SMA / ALS In CMT1 [pathologyoutlines.com]

Autosomal Recessive Spastic Paraplegia Type 27

Neuronal cell bodies of degenerating fibers are preserved, and no evidence of primary demyelination is noted. Loss of anterior horn cells is observed in some cases. [emedicine.medscape.com]

Neuronal cell bodies of degenerating axons are preserved and there is no evidence of primary demyelination.[16] Loss of anterior horn cells of the spinal cord are observed [en.wikipedia.org]

Neuronal cell bodies of degenerating axons are preserved and there is no evidence of primary demyelination. [18] Loss of anterior horn cells of the spinal cord are observed [en.wikipedia.org]

Diomedi-Bernardi-Placidi Syndrome

In all forms, the descending corticospinal tracts and, to a lesser extent, the dorsal columns and spinocerebellar tracts degenerate, sometimes with loss of anterior horn cells [merckmanuals.com]

Hereditary Motor and Sensory Neuropathy Type Okinawa

Prueba GEN(ES) Detalle NEUROPATIA SENSORIAL HEREDITARIA, CON PARAPLEJIA ESPASTICA CCT5 NEUROPATIA AUTONOMICA SENSORIAL HEREDITARIA 5 NGF NEUROPATIA DESMIELINIZANTE PERIFERICA, SINDROME DE WAARDENBURG Y ENFERMEDAD DE HIRSCHSPRUNG SOX10 NEUROPATIA AUDITIVA, AUTOSOMICA DOMINANTE DIAPH3 NEURONALES DE SUPERFICIE[…] [sequence.pe]

Pontocerebellar Hypoplasia Type 1A

Pontocerebellar hypoplasia (PCH) refers to a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem. Clinical features vary, but usually include severe developmental delay, dysmorphic features, seizures, and early death (summary by Durmaz et al., 2009). For a phenotypic[…] [ncbi.nlm.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 15

Neuronal cell bodies of degenerating axons are preserved and there is no evidence of primary demyelination.[18] Loss of anterior horn cells of the spinal cord are observed [en.wikipedia.org]

Motor Neuron Disease Type Madras

Post-mortem examination of the spinal cord showed a severe loss of anterior horn cells, prominent dilatation of vessels, diffuse, but sparse sprinkling of microglial cells [ncbi.nlm.nih.gov]

Distal Hereditary Motor Neuropathy Type 8

Despite the young age of the child at the time of autopsy, there was no pathological evidence of ongoing loss or degeneration of anterior horn cells suggesting that anterior [ncbi.nlm.nih.gov]

North, Autosomal dominant congenital spinal muscular atrophy: a true form of spinal muscular atrophy caused by early loss of anterior horn cells, Brain, 2012, 135, 6, 1714 [onlinelibrary.wiley.com]

"Autosomal dominant congenital spinal muscular atrophy: a true form of spinal muscular atrophy caused by early loss of anterior horn cells". [en.wikipedia.org]

Pontocerebellar Hypoplasia Type 8

Degeneration and loss of motor neurons in the anterior spinal horn Cerebellum. [ncbi.nlm.nih.gov]

Lower motor neuron deficits due to loss of anterior horn cells; manifestations of peripheral denervation incl weakness & muscle hypotonia from birth Mixed central (spastic [ncbi.nlm.nih.gov]

Typical findings of anterior horn involvement (i.e., neurogenic muscle atrophy): grouped atrophy, type II muscle fiber atrophy Spinal cord. [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 4

Pathological study: Observations on postmortem spinal cord reveal an extreme loss of anterior horn cells, demyelination and sclerosis of the ventrolateral columns. [rarediseasesindia.org]

[…] of anterior horn cells in the spinal cord and the motor cranial nerve nuclei in the lower brainstem produces weakness and muscle atrophy Amyotrophic Lateral Sclerosis -Demyelination [quizlet.com]

[…] of the anterior horn cells in the spinal cord and the brain stem nuclei. [omicsonline.org]

Lethal Arthrogryposis - Anterior Horn Cell Disease Syndrome

[…] by the association of arthrogryposis multiplex congenita and a severe form of motor neuron disease with loss of anterior horn cells in the spinal cord. [orpha.net]

horn cell loss ( Lethal arthrogryposis with anterior horn cell disease, LAAHD) was also shown to be allelic to LCCS1 and result from mutations in GLE1. [wikidoc.org]

The anterior toots (down) are much smaller than the dorsal ones due to loss of anterior horn cells. Loss of muscle in AMC Quadriceps from the case on the left. [neuropathology-web.org]

Autosomal Recessive Spastic Paraplegia Type 64

Autosomal Recessive Spastic Paraplegia Type 25

Neuronal cell bodies of degenerating fibers are preserved, and no evidence of primary demyelination is noted. Loss of anterior horn cells is observed in some cases. [emedicine.medscape.com]

X-Linked Spastic Paraplegia Type 34

Neuronal cell bodies of degenerating fibers are preserved, and no evidence of primary demyelination is noted. Loss of anterior horn cells is observed in some cases. [emedicine.medscape.com]

Autosomal Recessive Spastic Paraplegia Type 63

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Autosomal Recessive Spastic Paraplegia Type 44

BIs are seen not only in the residual large anterior horn cells but also in the small anterior horn cells and neurons in the intermediolateral nuclei. [39] Generally, BBs [emedicine.medscape.com]

Adult Spinal Muscular Atrophy

In pathologic terms, the disease was characterized by loss of anterior horn cells. [emedicine.medscape.com]

horn cells (the lower motor neurons) in the spinal cord and the brain stem nuclei. [genomicseducation.hee.nhs.uk]

Postpoliomyelitis Syndrome

The cause of postpoliomyelitis syndrome may be related to further loss of anterior horn cells due to aging in a population of neurons already depleted by earlier poliovirus [merckmanuals.com]

Due to the slow loss of anterior horn cells with normal aging, motor units undergo continuous remodeling. [now.aapmr.org]

Scapuloperoneal Spinal Muscular Atrophy

anterior horn cells with secondary muscle loss and weakness. [ncbi.nlm.nih.gov]

In pathologic terms, the disease was characterized by loss of anterior horn cells. [emedicine.medscape.com]

horn cell loss. [ncbi.nlm.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 26

Neuronal cell bodies of degenerating fibers are preserved, and no evidence of primary demyelination is noted. Loss of anterior horn cells is observed in some cases. [emedicine.medscape.com]

Autosomal Recessive Spastic Ataxia Type 2

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]

Cree Mental Retardation Syndrome

Ataxia telangiectasia AR Progressive ataxia, choreoathetosis, anterior horn cell loss, immune deficiency, scleral telangiectasia. [neupsykey.com]

scoliosis Spinal muscular atrophy 1, 2, 3 AR Loss of anterior horn cells; limb weakness, loss of tendon jerks; visible fasciculation may be limited to tongue in infantile [neupsykey.com]

Normal development for first six months, followed by acquired microcephaly, loss of hand skills and replacement by stereotypies, regression of skills, seizures, spasticity [neupsykey.com]

Autosomal Recessive Spastic Paraplegia Type 46

85 Dorsal root ganglia, posterior roots, and peripheral nerves are usually normal, as are anterior horn cells, although one report did demonstrate degeneration of anterior [jnnp.bmj.com]

Autosomal Dominant Spastic Paraplegia Type 38

Neuronal cell bodies of degenerating fibers are preserved. 47. Loss of anterior horn cells is observed in some cases. [slideshare.net]

Neuronal cell bodies of degenerating fibers are preserved, and no evidence of primary demyelination is noted. Loss of anterior horn cells is observed in some cases. [emedicine.medscape.com]

Autosomal Recessive Spastic Paraplegia Type 57

Neuronal cell bodies of degenerating fibers are preserved and there is no evidence of primary demyelination. [7] Loss of anterior spinal horn is observed in some cases. [ipfs.io]