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1,470 Possible Causes for Loss of Axillary Hair, Metyrapone Challenge Test Abnormal, Midline Defects

  • Panhypopituitarism

    CONCLUSION: These data demonstrate that homozygous HESX1 mutation causing an R160H substitution can result in panhypopituitarism without midline defects.[] Nonspecific symptoms are most frequently seen in the form of exercise intolerance, abdominal pain, loss of axillary and pubic hair weakness or fatigue, Increase in weight,[] We report on a neonate with unexplained heart failure and minor physical anomalies, suggesting a midline defect. She was diagnosed with complete CPHD.[]

  • Anterior Pituitary Hypofunction

    It is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects.[] […] of pubic and axillary hair Atrophy of breast and Testis What are the steps in evaluating anterior pituitary hypofunction?[] A genetically heterogeneous disorder caused by hypothalamic gnrh deficiency and olfactory nerve defects.[]

  • Hypothalamo-Pituitary Disorder

    Midline Defects Iatrogenic Septo-optic dysplasia (without HESX1 mutation) Exogenous glucocorticoids Pituitary surgery Cranial irradiation Post-treatment for hypercortisolism[] Failure to lactate and involution of the breasts ar e f oll o wed by loss of axillary and pubic hair.[] Table 1 Causes of central hypoadrenalism Genetic Tumor Isolated ACTH deficiency Non-functioning pituitary adenoma POMC mutation/cleavage defect Functional pituitary adenoma[]

  • Hypogonadism

    Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[] […] of axillary, facial, and pubic hair Small or shrinking testes Poor concentration and memory Sleep disturbances, insomnia Increased body fat and body mass index Menopausal-type[] […] vesicles, penis, and scrotum; the development of male hair distribution, including facial, pubic, chest, axillary hair; laryngeal enlargement; vocal chord thickening; alterations[]

    Missing: Metyrapone Challenge Test Abnormal
  • Luteinizing Hormone Deficiency

    There was no anosmia, midline defects or gynaecomastia. He had scanty pubic hair which came only after testosterone injection (Tanner stage 2) but no axillary hair.[] Weakness, hypoglycemia, weight loss, and decreased axillary and pubic hair suggest the diagnosis.[] It is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects.[]

    Missing: Metyrapone Challenge Test Abnormal
  • Hypopituitarism

    , eye anomalies, and midline/ventral defects).[] […] of axillary and pubic hair In women: cessation of menstruation (amenorrhea), breast atrophy, vaginal dryness, absence of milk production in new mothers (Sheehan’s syndrome[] Congenital: Kallmann's syndrome (congenital hypogonadotropic hypogonadism with midline defects such as anosmia) [ 2 ]. Autoimmune: lymphocytic hypophysitis.[]

    Missing: Metyrapone Challenge Test Abnormal
  • Hypothyroidism

    defects of the brain, should alert the physician to suspect the diagnosis of septo-optic dysplasia.[] Physical signs of hypothyroidism include the following: Weight gain Slowed speech and movements Dry skin Jaundice Pallor Coarse, brittle, straw-like hair Loss of scalp hair[] […] polyuria (from antidiuretic hormone deficiency), or small phallus in boys (from gonadotropin deficiencies), along with the presence of blindness, congenital nystagmus, or midline[]

    Missing: Metyrapone Challenge Test Abnormal
  • Cushing's Disease

    The management of critically ill Cushing's disease (CD) patients is extremely challenging. Pasireotide is indicated for the treatment of CD patients when pituitary surgery is unfeasible or has not been curative, but no data are available about the use of this drug as pre-operative treatment in critically ill patients.[…][]

    Missing: Loss of Axillary Hair Midline Defects
  • Pituitary Neoplasm

    Pituitary neoplasms are benign adenomas in the vast majority of cases and can secrete pituitary hormones such as prolactin and growth hormone. Symptoms include a headache and bitemporal hemianopsia in larger tumors, while hormone-induced effects such as acromegaly, galactorrhea, and Cushing's disease may be[…][]

    Missing: Loss of Axillary Hair Midline Defects
  • Hypogonadotropic Hypogonadism Type 8

    […] producing GRH–gonadotropin-releasing hormone; FSH and LH impairs sperm and androgen production Clinical Delayed puberty, micropenis, eunuchoid features, cryptorchidism, midline[] Thus, palor or loss of pubic and axillary hair is more common in patients with associated adrenal insufficiency that completes the androgen deficiency [ 8 ].[] Occasionally the diagnosis is made earlier due to investigation of other associated anomalies, including: midline defects cleft lip and palate renal agenesis sensorineural[]

    Missing: Metyrapone Challenge Test Abnormal