Loss of Gait: Causes & Reasons

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Possible Causes for Loss of Gait

Charcot-Marie-Tooth Disease

[…] and gait disturbance. [ncbi.nlm.nih.gov]

Sensorineural hearing loss. It is important to suspect CMTX5 when boys with early-onset sensorineural hearing loss develop gait disturbance and visual disturbance. [ncbi.nlm.nih.gov]

Foot drop causes a person to trip frequently and develop an abnormal gait. Loss of hand function. [ucsfbenioffchildrens.org]

Episodic Encephalopathy due to Thiamine Pyrophosphokinase Deficiency

These episodes result in progressive neurologic dysfunction manifest as gait disturbances, ataxia, dystonia, and spasticity, which in some cases may result in loss of ability [uniprot.org]

CANOMAD Syndrome

Signs and symptoms of CANOMAD may include loss of muscle, tendon, and joint sensation, abnormal gait (walk), ataxia, tingling sensation on the skin around the mouth or extremities [malacards.org]

Charcot-Marie-Tooth Disease Type 4D

Abnormality of the musculoskeletal system Distal amyotrophy Distal muscle weakness Abnormality of the nervous system Abnormal auditory evoked potentials Areflexia Axonal loss [ncbi.nlm.nih.gov]

Decreased nerve conduction velocity Distal sensory impairment Gait disturbance Onion bulb formation Segmental peripheral demyelination/remyelination Ear malformation Hearing [ncbi.nlm.nih.gov]

Hereditary Motor and Sensory Neuropathy Type 5

Additional variable features may include proximal muscle weakness, abnormal gait, arthrogryposis, scoliosis, cognitive impairment, and spasticity. [orpha.net]

2 characterized by early childhood-onset of slowly progressive, predominantly distal, lower limb muscle weakness and atrophy, delayed motor development, variable sensory loss [orpha.net]

Lassa Fever

Transient hair loss and gait disturbance may occur during recovery. [web.archive.org]

Transient hair loss and gait disturbance may occur during recovery. Patients may die from shock. [dailypost.ng]

Transient hair loss and gait disturbance may occur during recovery. Death usually occurs within 14 days of onset in fatal cases. [who.int]

Charcot-Marie-Tooth Disease Type 2E

distal sensory loss and gait ataxia (lack of coordination), probably due to the sensory symptoms. [cmtausa.org]

Roussy- Lévy Syndrome is used to describe a phenotype (or expression of symptoms) that includes high arches, loss of reflexes, distal limb weakness, tremor in the upper limbs [cmtausa.org]

Charcot-Marie-Tooth Disease Type 4B2

[…] number of peripheral myelinated nerve fibers Difficulty walking Distal sensory impairment Onion bulb formation Segmental peripheral demyelination/remyelination Steppage gait [ncbi.nlm.nih.gov]

Ear malformation Sensorineural hearing loss IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information [ncbi.nlm.nih.gov]

Biotinidase Deficiency

A 5-year-old girl developed acute visual loss associated with optic atrophy, and disturbance of gait with predominantly lower-limb pyramidal signs. [ncbi.nlm.nih.gov]

One of the patients had residual gait ataxia at follow-up and none had optic atrophy or sensorineural hearing loss. [neurologyindia.com]

The disorder classically presents in infancy or early childhood with intractable seizures, hypotonia, ataxia, hearing loss, dermatitis, and alopecia. [ncbi.nlm.nih.gov]

Superficial Siderosis of the Central Nervous System

We report a 78-year-old man in oral anticoagulant therapy, who presented neurosensory hearing loss, gait ataxia and spastic paraparesis. [ncbi.nlm.nih.gov]

Patients often present in adulthood with hearing loss and slowly progressive gait ataxia. [mayoclinic.org]

The most common neurologic manifestations include progressive gait ataxia, sensorineural hearing loss, and corticospinal tract signs. [ncbi.nlm.nih.gov]

Subacute Combined Degeneration of Spinal Cord

gait ataxia distal weakness, especially in legs Subacute Combined Degeneration -syndrome of sensory loss -spastic paresis associated with pathological lesions in dorsal columns [quizlet.com]

[…] of sphincter control and gait impairment Diagnosis Schilling test: radiolabeled cyanocobalamin is administered orally and its excretion is measured in the urine Increased [pathologyoutlines.com]

[…] sensory gait ataxia, and distal muscle weakness, especially of the legs. [radiopaedia.org]

Siderosis

Patients with SSCNS vestibulopathy present with dizziness often along with the common symptoms of progressive hearing loss and gait instability ( 8 ). [frontiersin.org]

The highest pitches are often lost first, and over a period of one to twelve years hearing loss progresses to total deafness or loss of all hearing but low pitches. [en.wikipedia.org]

He has significant gait and limb ataxia. At age 4, he had a head injury during a MVA with prolonged coma. [frontiersin.org]

Bing-Neel Syndrome

Patients presented with a variety of neurological signs and symptoms including seizures, hearing loss, cognitive impairment, gait instability and lower extremity weakness. [bloodjournal.org]

Bethlem Myopathy Type 2

The loss of gait in the second case is much more precocious caused by the loss of more incisive muscle strength and more severe contractures. [pepsic.bvsalud.org]

[…] acquired this motor frame, illustrating the severity of this disease and correlating with subsequent motor losses (ZHANG et al., 2014). [pepsic.bvsalud.org]

In both cases, motor functional losses occur, with Bethem's myopathy being milder in relation to Ullrich's Congenital Muscular Dystrophy. [pepsic.bvsalud.org]

Tabes Dorsalis

Symptoms may not appear for many years after the initial infection and include weakness, diminished reflexes, unsteady gait, and loss of coordination, episodes of intense [secure.ssa.gov]

Physical findings: Diagnostic testing along with physical examination may show evidence of damage to the spinal cord and myelopathy with characteristic high stepping “tabetic gait [secure.ssa.gov]

Symptoms may not appear for some decades after the initial infection and include weakness, diminished reflexes, unsteady gait, progressive degeneration of the joints, loss [ninds.nih.gov]

Sensory Ataxic Neuropathy - Dysarthria - Ophthalmoparesis Syndrome

The phenotype is largely variable: The common clinical feature appears to be sensory ataxia, and other symptoms include myopathy, seizures, hearing loss, progressive gait [link.springer.com]

[…] disturbance, 2) bilateral, profound, prelingual sensorineural hearing loss and 3) progressive optic neuropathy. [mendelian.co]

1) progressive distal muscle weakness and atrophy (first appearing and more prominent in the lower extremities than the upper) which usually manifests with foot drop and gait [mendelian.co]

Charcot-Marie-Tooth Disease Type 2T

Other features may include hand muscle involvement, hypo/arreflexia, gait disturbances, muscle cramps, toe abnormalities and mild cardiomyopathy. [rarediseases.info.nih.gov]

[…] subtype of axonal hereditary motor and sensory neuropathy characterized by distal muscle weakness and atrophy (principally of peroneal muscles) associated with distal sensory loss [rarediseases.info.nih.gov]

Hyperekplexia Type 4

At age 32 years, she developed anxiety, weight loss, and gait difficulties. [ng.neurology.org]

Furthermore, the periods of rigidity may cause some individuals to fall without a loss of consciousness. [verywellhealth.com]

Exaggeration of reflexes (hyperreflexia), and an unstable way of walking (gait) may also occur. [rarediseases.org]

Susac Syndrome

A 30-year-old man presented with acute onset of superior vision loss, unsteady gait, and hearing loss. [ncbi.nlm.nih.gov]

I know others who suffer with encephalopathy (brain lesions that cause paranoia & memory loss), spastic gait, numbness, loss of balance and muscle pain. [rarediseaseday.org]

Wernicke-Korsakoff Syndrome

Neurological examination demonstrated ataxia of gait and loss of orientation. [ncbi.nlm.nih.gov]

[…] barrier breakdown (vasogenic edema) Clinical features Wernicke encephalopathy: ocular abnormalities (nystagmus / ophthalmoplegia), mental status changes (confusion) and gait [pathologyoutlines.com]

Presentation Clinical diagnosis that does not require imaging studies Wernicke's encephalopathy encephalopathy ( disorientation, indifference, inattentiveness) ophthalmoplegia gait [step1.medbullets.com]

CAPOS Syndrome

She came to our hospital due to optic atrophy with bilateral amaurosis, sensorineural hearing loss, and gait ataxia, developing progressively from childhood. [elsevier.es]

and has symptoms including gait ataxia, hemiparesis and ataxia, truncal. [malacards.org]

In childhood, he developed bilateral optic atrophy and bilateral sensorineural hearing loss. [bora.uib.no]

Rett Syndrome

Loss of speech Loss of purposeful use of hands Involuntary hand movements such as handwashing Loss of mobility or gait disturbances Loss of muscle tone Seizures or Rett “episodes [rettsyndrome.org]

Typical features include a loss of purposeful hand skills, development of hand stereotypies, loss of spoken language, gait abnormalities, and acquired microcephaly. [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 5

distal sensory loss and gait ataxia (lack of coordination), probably due to the sensory symptoms. [cmtausa.org]

[…] impairment and loss of reflexes due to impaired function of motor nerves. [genecards.org]

Reports of cold feet, hair loss, or leg edema are common. [emedicine.medscape.com]

Marchiafava-Bignami Disease

Patients can present with acute, subacute, or chronic onset of mental status change varying from lethargy to coma, seizure, ocular movement dysfunction, memory loss, and gait [msdmanuals.com]

Physical examination revealed loss of short- and long-term memory, unsteady gait, rigidity with cogwheel-like movement, and lack of motor coordination (particularly fine motor [ajnr.org]

Classic Progressive Supranuclear Palsy Syndrome

[…] of coordination, unsteady gait (walking pattern) Mild-to-moderate dementia Difficulty using knowledge Forgetfulness Indifference ( apathy ) Slowed thought processes Personality [primumn0nn0cere.wordpress.com]

The loss of independent gait and the inability to stand unassisted occurs less than three years after disease onset [ 10 ] . [patient.info]

Less commonly, patients present with cognitive loss and no motor signs. [rarediseases.org]

Wernicke Encephalopathy

WE was suspected because she also developed loss of appetite for two weeks, and no other laboratory findings could explain her unsteady gait. [ncbi.nlm.nih.gov]

Examination revealed counting fingers acuity in both eyes with central scotomas, color vision loss, horizontal nystagmus, and gait ataxia. [ncbi.nlm.nih.gov]

She now presented with sub-acute onset of visual loss in both her eyes, and gait disturbance with unsteadiness. [ncbi.nlm.nih.gov]

Friedreich Ataxia

Introduction : Friedreich ataxia (FRDA) is an autosomal recessive disorder which manifests with progressive instability, leading ultimately to loss of independent gait, dysarthria [doi.org]

The classic phenotype of Friedreich ataxia is characterized by dysarthria, progressive limb and trunk ataxia, loss of reflexes, and gait disturbance with the onset of disease [ncbi.nlm.nih.gov]

Equistasi may improve limb and gait ataxia – a loss of control of voluntary muscular movement – in patients with hereditary cerebellar ataxia, such as Friedreich’s ataxia, [equistasi.com]

Adult-Onset Autosomal Recessive Cerebellar Ataxia

[…] autonomous gait. [oatext.com]

[…] weakness, loss of joint position sense and limb dysmetria. [en.wikipedia.org]

Clinical features Areflexia, proprioceptive dysfunction, loss of reflexes, and Babinski sign (prominent findings) By 5-10 years, gait disturbances and cerebellar signs Malabsorptive [emedicine.medscape.com]

Autosomal Recessive Spinocerebellar Ataxia

[…] autonomous gait. [oatext.com]

[…] weakness, loss of joint position sense and limb dysmetria. [en.wikipedia.org]

Extraskeletal Myxoid Chondrosarcoma

Material: A 63-year-old man presented with progressive hearing loss and gait imbalance. [nebraska.pure.elsevier.com]

A 63-year-old man presented with progressive hearing loss and gait imbalance. [ncbi.nlm.nih.gov]