Myxedema or severe hypothyroidism is clinical condition where the thyroid gland does not produce any thyroid hormone. In some cases, myxedema condition is also being referred to as underactive thyroid. Myxedema typically present with a distinct facial appearance, hoarse slow speech, and dryness of the skin. The…[1]
Thallium poisoning is very rare and may occur accidentally, through occupational exposure and because of its potency, it is described as a weapon of intentional poisoning. Symptoms are primarily related to the gastrointestinal and nervous system, while diffuse alopecia 3 weeks after ingestion is typical for thallium…[2]
Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by generalized gastrointestinal polyps, alopecia, nail changes and hyperpigmentation. In many cases, the symptoms appear in the following order: Gastrointestinal symptoms Weight loss Weakness Edema Ectodermal changes The ectodermal changes occur…[3]
Hemochromatosis is the abnormal accumulation of iron in parenchymal organs and the most common form of iron overload disease. It may be inherited or acquired. The patients suffering from hemochromatosis have the following clinical picture. The skin of these patients acquires a bronze pigmentation due to the…[4]
Generalized lipodystrophy is a disorder characterized by loss of adipose tissue and, usually, metabolic disturbance due to deficiency of hormones derived from these tissues, most importantly leptin. Generalized lipodystrophy (GL) may be divided in congenital GL, also known as Berardinelli-Seip syndrome and acquired GL,…[5]
Hypothyroidism is a common disorder resulting from deficiency of thyroid hormone. Iodine deficiency is the most common cause of hypothyroidism worldwide. It can be associated with a number of symptoms including fatigue, weight gain, decreased appetite, cold intolerance, bradycardia, dry skin, hair loss, myalgia,…[6]