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96 Possible Causes for Loss of Motor Skills, Metabolic Acidosis, Rhabdomyolysis

  • Long Chain Hydroxyacyl-CoA Dehydrogenase Deficiency

    Clinical considerations: Poor feeding, vomiting, lethargy Hypoglycemia Metabolic acidosis Hepatomegaly Cardiac insufficiency History of sudden unexpected death in a sibling[archildrens.org] Babies and children who are not treated may have: poor weight gain delays in learning delays in walking and other motor skills enlarged liver and other liver problems enlarged[newbornscreening.info] These long chain defects have variable presentations, they may present in the neonate or infant with sudden death, hepatopathy (Reyes disease), hypoketotic hypoglycaemia, rhabdomyolysis[pediatricfocus.wordpress.com]

  • Leigh's Disease

    Investigations revealed metabolic acidosis, high serum and cerebrospinal fluid lactate.[ncbi.nlm.nih.gov] The symptoms of the disease usually progress at a rapid rate, with the earliest signs potentially being poor sucking ability and a loss of motor skills and head control.[disabled-world.com] […] are a few reports regarding the use of succinylcholine in patients with Leigh disease, we would suggest that succinylcholine be avoided because of the potential risks of rhabdomyolysis[saudija.org]

  • Glutaric Aciduria

    The neonatal-onset form presents as an overwhelming illness, with severe hypoglycemia and metabolic acidosis leading to rapid death.[ncbi.nlm.nih.gov] […] of motor skills and convulsions resulting in bilateral striatal injury with severe secondary dystonia and occasionally subdural and retinal hemorrhage.[orpha.net] KEYWORDS: glutaric aciduria type II; multiple acyl Co-A dehydrogenase deficiency; myopathy; rhabdomyolysis[ncbi.nlm.nih.gov]

  • MELAS Syndrome

    He than had several stroke-like episodes and periods of unconsciousness, associated with severe metabolic acidosis. Muscle cytochrome C oxidase was abnormally low.[ncbi.nlm.nih.gov] Altered consciousness Motor skills loss Intellectual disability Causes MELAS syndrome is triggered by transmutations in the gene material – DNA – in the mitochondria.[syndrome.org] Furthermore, this mutation was associated with exercise-induced rhabdomyolysis, hearing loss, seizures, cardiomyopathy, and autism in the large kindred.[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    CONCLUSIONS: The findings in HE alcoholics are consistent with the metabolic acidosis seen in this condition.[ncbi.nlm.nih.gov] skills, or slurred speech.[cdc.gov] Of five chronic alcoholics with acute skeletal muscle necrosis (rhabdomyolysis) three developed acute heart failure with disturbances of rhythm and conduction.[ncbi.nlm.nih.gov]

  • Alcohol Abuse

    Recent FDA warning of metabolic acidosis, especially with renal or liver disease None Consider interactions withother anticonvulsant drugs. 53 Dizziness, somnolence, ataxia[aafp.org] There may be a dramatic loss of motor skills and coordination. Vision may be significantly blurred.[americanaddictioncenters.org] Rhabdomyolysis is a severe and life-threatening condition in which skeletal muscle is damaged.[ncbi.nlm.nih.gov]

  • Combined Oxidative Phosphorylation Defect Type 14

    Metabolic acidosis is often present but may be a late manifestation.[merckmanuals.com] The gradual cumulative effects of these episodes often result in variable combinations of loss of motor skills (speech, movement, and eating), impaired sensation (vision loss[umdf.org] MRPL44 Copper deficiency Deafness Hyperhomocysteinemia Leber's Leigh's Leukoencephalopathy with ovarian failure : AARS2 Myopathy Infantile-onset Fatal Benign Adult-onset Rhabdomyolysis[neuromuscular.wustl.edu]

  • Glutaric Aciduria Type 2

    The first group of MADD-S patients are often premature presenting with severe non-ketotic hypoglycemia, hypotonia, hepatomegaly and severe metabolic acidosis within the first[orpha.net] This new rare disorder is characterized by normal early development followed by a progressive loss of mental and motor skills.[pliem.co.za] We present a 14-year-old boy with a background of autistic spectrum disorder who presented with severe muscle weakness and significant rhabdomyolysis.[journals.sagepub.com]

  • Duchenne Muscular Dystrophy

    Metabolic acidosis is a life-threatening, potentially preventable complication in older DMD patients.[ncbi.nlm.nih.gov] […] of motor skills development fatigue rapidly worsening weakness in the legs, pelvis, arms, and neck DMD is a genetic disease.[healthline.com] DMD is usually a challenge for the anaesthesiologist, with poor cardiac function, a high risk of developing rhabdomyolysis, and the probable life-threatening complications[ncbi.nlm.nih.gov]

  • Propionic Acidemia

    It is frequently accompanied by metabolic acidosis with anion gap, ketonuria, hypoglycemia, hyperammonemia, and cytopenias.[ncbi.nlm.nih.gov] In few cases of delayed-onset propionic acidemia, patient present long-term effects including: Delay in development of communication and motor skills Mental retardation with[healthhype.com] […] ketogenic dietBlood lactate and pyruvate (before and 1 hour after lunch), CSF lactate and pyruvateFatty acid -oxidation defectsAR Any Acute signs: encephalopathy, coma, rhabdomyolysis[vdocuments.us]

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