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18 Possible Causes for Loss of Motor Skills, Rhabdomyolysis, Thiamine Decreased

  • Alcohol Abuse

    There may be a dramatic loss of motor skills and coordination. Vision may be significantly blurred.[] Rhabdomyolysis is a severe and life-threatening condition in which skeletal muscle is damaged.[] skills, or slurred speech.[]

  • Chronic Alcoholism

    skills, or slurred speech.[] This means the number of thiamine transporters to bring thiamine into the enterocyte was decreased.[] Of five chronic alcoholics with acute skeletal muscle necrosis (rhabdomyolysis) three developed acute heart failure with disturbances of rhythm and conduction.[]

  • Leigh's Disease

    The symptoms of the disease usually progress at a rapid rate, with the earliest signs potentially being poor sucking ability and a loss of motor skills and head control.[] Abstract A series of children with Leigh's disease had normal hepatic pyruvate carboxylase activity, increased cerebral thiamine diphosphate, and decreased cerebral thiamine[] […] are a few reports regarding the use of succinylcholine in patients with Leigh disease, we would suggest that succinylcholine be avoided because of the potential risks of rhabdomyolysis[]

  • Benzodiazepine Overdose

    Benzodiazepine addicts also have a higher risk for developing dementia, an illness affecting the brain that causes gradual memory loss and problems with language and motor[] […] inhibitory) and upregulation of NMDA (excitatory) Intoxication presentation wide and varied - talkative, flirtatious, aggressive, moody, disinhibited treatment secure airway thiamine[] Lorazepam, phenytoin, and phenobarbital were administered; however, seizures persisted for 4 hours, resulting in rhabdomyolysis, acute renal failure, severe brain damage,[]

  • Isolated Complex I Deficiency

    The gradual cumulative effects of these episodes often result in variable combinations of loss of motor skills (speech, movement, and eating), impaired sensation (vision loss[] […] and, subsequently, decreased thiamine uptake by components of the respiratory complex of the mitochondria.[] 2012 ; Ohlenbusch et al 2012 ), encephalomyopathy ( Jackson et al 2014 ), Kearns-Sayre syndrome and other mitochondrial myopathies ( Rivner et al 1989 ; Sonam et al 2014 ), rhabdomyolysis[]

  • Wolfram Syndrome

    The condition, which is caused by a mutation in a single gene, leads to diabetes, hearing and vision loss as well as nerve cell damage and difficulties with motor skills,[] When treated with thiamin, vitamin B 6, WS patients usually decrease their need for insulin, and blood findings such as anemia can return to normal. (3) Diabetes Mellitus[] Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia. J Inherit Metab Dis. 2012;35:1119-28.[]

  • Encephalopathy

    Difficulty with balance and motor skills. Like Alzheimer’s dementia, CTE is characterized by tangles of an abnormal form of the protein tau in the brain.[] Wernicke-Korsakoff syndrome is one type of alcoholic encephalopathy that is caused by thiamine (vitamin B1) deficiency due to malnutrition.[] It is clinically characterized by metabolic acidosis, refractory bradycardia, rhabdomyolysis, renal failure, hyperlipidemia, and hepatomegaly.[]

  • Marchiafava Bignami Disease

    Loss of purposive hand movements & acquired fine motor manipulative skills with subsequent development of stereotyped hand movements.[] Intravenous thiamine (100 mg) was given, with clinical and radiographic improvement.[] […] after admission we started a small dose citalopram (SSRI) to treat his depression and within 24-hours he developed symptoms and signs suggestive of serotonin syndrome with rhabdomyolysis[]

  • Citrullinemia Type 2

    This new rare disorder is characterized by normal early development followed by a progressive loss of mental and motor skills.[] Decreased energy production in thiamine deficiency is due to? A. It is a cofactor for oxidative reduction B. It is required for transamination reactions C.[] The myopathic form is the less severe one and is characterized by recurrent attacks of rhabdomyolysis, muscle pain, and weakness triggered by prolonged physical exercise,[]

  • Spastic Ataxia with Congenital Miosis

    Initially, symptoms may be slowly progressive or may plateau, sometimes followed by a rapid loss of motor skills over a few weeks, during which time the diagnosis is commonly[] -Thiamine deficiency can possibly cause a GI syndrome of nausea, vomiting, abdominal pain, and lactic acidosis.[] Rare rhabdomyolysis. Being treated for HLD. Increased CK, normal ESR. Muscle pain, cramps and weakness involving the proximal muscles.[]

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