Loss of Myelin: Causes & Reasons

Possible Causes for Loss of Myelin

[…] of the myelin surrounding the neurons. [rarediseases.info.nih.gov]

Dysmyelination – loss of defective myelin Enzymatic defects can be in: • • • Peroxisomes Mitochondria Lysosomes. 24. Hypomyelination 25. Myelination PNS CNS 26. [slideshare.net]

It has been believed that hypomyelination is caused by the loss of the basic myelin protein gene (18q22-23), although some studies have found that pathological tests reveal [plaza.umin.ac.jp]

Spinal Demyelination

Diseases that are characterized by this loss of myelin are referred to as demyelinating diseases. [news-medical.net]

Myelin stains show complete loss of myelin or pallor of myelin staining. [neuropathology-web.org]

In MS, the loss of myelin (demyelination) is accompanied by a disruption in the ability of the nerves to conduct electrical impulses to and from the brain. [msif.org]

Demyelinating Disease

[…] and infarct and demyelinating lesions have loss of myelin and show foamy macrophages phagocytizing the debris. [quizlet.com]

Demyelinating diseases consists of a group of disorders characterized by the loss of myelin with relative axonal sparing. [symptoma.com]

Longer standing lesions are characterized by a total loss of myelin and oligodendrocytes, an intense astrogliosis, variable degrees of axonal loss, and a scant residual infiltrate [streetdirectory.com]

Krabbe Disease

In the absence of GALC, progressive loss of myelin and accumulation of a neurotoxic substrate lead to incapacitating loss of motor and cognitive function and death, typically [ncbi.nlm.nih.gov]

Then, thirty years ago a hypothesis was introduced to explain the pathogenetic mechanism underlying the rapid and complete loss of myelin and myelinating cells. [jstage.jst.go.jp]

The loss of MYELIN disrupts normal conduction of nerve impulses. [hon.ch]

Hereditary Sensory Neuropathy

[…] root ganglion cells and loss of myelinated fibres in both peripheral nerves and posterior columns of the spinal cord. [ncbi.nlm.nih.gov]

The morphological finding of marked fascicular atrophy, a profound loss of myelinated fibres and a relative preservation of unmyelinated fibres are typical of those previously [ncbi.nlm.nih.gov]

Nerve biopsy in three patients showed an axonopathy with a loss of myelinated nerve fibres of all diameters and also of unmyelinated axons. [ncbi.nlm.nih.gov]

Autosomal Dominant Hereditary Sensory and Autonomic Neuropathy

The sural nerve biopsy confirmed the electrophysiological findings, revealing severe loss of myelinated and unmyelinated fibers with regeneration clusters. [ncbi.nlm.nih.gov]

Sural nerve biopsy showed loss of myelinated and unmyelinated fibers. [ncbi.nlm.nih.gov]

There was marked loss of myelinated fibers, especially those of large diameter, and there was comparable loss of unmyelinated fibers. [neurology.org]

Baló Concentric Sclerosis

Brain biopsy showed an inflammatory demyelinating lesion with apoptotic oligodendrocytes and a loss of myelin‐associated glycoprotein, pathological features typical for pattern [doi.org]

Myelin stains show complete loss of myelin or pallor of myelin staining. [neuropathology-web.org]

The loss of myelin sheaths in the optic nerves was first recorded by Achard and Guinon, 6 who described almost complete disappearance of myelin in the optic nerves of their [jamanetwork.com]

Diphtheritic Neuropathy

At an advanced stage, there is loss of myelinated axons. [neuropathology-web.org]

The nerve biopsy in CMT1 shows demyelination, myelin regeneration (thin myelin), axonal loss, and onion bulbs. [tratamientoneuropatia.com]

Segmental demyelination, originally described in experimental lead poisoning, is characterized by breakdown and loss of myelin over a few segments. [neuropathology-web.org]

Leukodystrophy

Then, thirty years ago a hypothesis was introduced to explain the pathogenetic mechanism underlying the rapid and complete loss of myelin and myelinating cells. [jstage.jst.go.jp]

[…] of myelin Metachromatic leukodystrophy: brown metachromasia in peripheral nerve Other: Pelizaeus-Merzbacher disease: loss of myelin Pelizaeus- Merzbacher disease: cerebellar [pathologyoutlines.com]

Like the leukodystrophies, MS is caused by the loss of myelin from the axons; however, the cause is different. [ulf.org]

Subacute Combined Degeneration of Spinal Cord

The pathological findings of subacute combined degeneration consist of patchy losses of myelin in the dorsal and lateral columns. [en.wikipedia.org]

This is followed by disintegration of myelin, which is removed by macrophages. L oss of axons also occurs, but is less severe than the loss of myelin. [neuropathologyweb.org]

The histopathology of WKS is incomplete loss of neurons, damage of axons and myelin which casuses loosening or vacuolization of the neuropil, and punctate hemorrhages.The [neuropathologyweb.org]

Pelizaeus-Merzbacher Disease

The mutation in PLP1 in PMD results in loss of myelin and that, in turn, causes the neurological abnormalities. [medicinenet.com]

[…] of myelin (the sheath around the nerve protecting it). [dic.academic.ru]

Pelizaeus-Merzbacher disease: A disorder of the central nervous system (CNS) in which there is loss of myelin, the sheath around the nerves. [medicinenet.com]

Channelopathy-Associated Congenital Insensitivity to Pain

A sensory nerve biopsy shows a marked reduction in the number of myelinated nerves and degeneration of those myelinated nerves, and a lesser loss of non-myelinated nerves. [contact.org.uk]

There is absence of unmyelinated fibers in addition to the loss of small myelinated ones. [pediatricneurosciences.com]

In several studies skin biopsy has shown absence of epidermal innervation and loss of most dermal innervations as well as accompanying loss of unmyelinated and thinly myelinated [indianjpain.org]

CANOMAD Syndrome

Medical Term Other Names Description Peripheral demyelination Demyelination A loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous [rarediseases.oscar.ncsu.edu]

A nerve biopsy showed near complete loss of myelinated axons with preservation of smaller axons. Rituximab was the most effective immunotherapy. [profiles.wustl.edu]

Acute Pandysautonomia

In 1980, Colan et al. reported a patient with acute autonomic and sensory neuropathy, manifesting severe sensory impairment and dysautonomia with marked loss of myelinated [unboundmedicine.com]

The dorsal columns of the spinal cord showed a loss of myelinated fibres (figure B). [jnnp.bmj.com]

Our patient, as those in previous reports3, had a loss of myelinated fibres on sural nerve biopsy. [jnnp.bmj.com]

Neuromyelitis Optica

This also results in the brain and spinal cord the loss of myelin, the fatty substance that acts as insulation around nerve fibers and helps nerve signals move from cell to [ninds.nih.gov]

NMO leads to loss of myelin, which is a fatty substance that surrounds nerve fibers and helps nerve signals move from cell to cell. [medicinenet.com]

[…] of the arms and legs, along with sensory disturbances and loss of bladder and bowel control. [medicinenet.com]

Myelitis

Loss of myelin often leads to spinal cord scarring that blocks nerve impulses and results in physical problems. Transverse myelitis is a relatively rare disease. [stlouischildrens.org]

This inflammation can damage myelin, the fatty substance that covers your nerves. [stlouischildrens.org]

Presenile Dementia with Bone Cysts

Histological findings consist of loss of myelin in the frontal lobes. [thefreelibrary.com]

Histopathologically, loss of axons and myelin as well as fibrillary gliosis are observed. Molecular genetic testing confirms the diagnosis in ambiguous cases. [orpha.net]

Loss of myelin, presence of axonal spheroids (g), and infiltration of microglia and macrophages labeled with antibodies against Iba1 (h) and MHC class II (i) are visible in [springermedizin.de]

Central Pontine Myelinolysis

There is loss of myelin and less severe loss of axons. Neurons of the nuclei pontis are relatively spared. No inflammation is seen. [neuropathology-web.org]

Central pontine myelinolysis (CPM) is rare demyelinating disorder characterized by loss of myelin in the center of the basis pontis. [ncbi.nlm.nih.gov]

[…] of myelin in nerve fibres running through the middle of the PONS in the brainstem. [medical-dictionary.thefreedictionary.com]

Neonatal Adrenoleukodystrophy

Adrenoleukodystrophy Definition Adrenoleukodystrophy is a rare genetic disease characterized by a loss of myelin surrounding nerve cells in the brain and progressive adrenal [medical-dictionary.thefreedictionary.com]

While the adrenal disorder that arises with ALD can be treated with medication, the primary damage caused by ALD is the progressive loss of myelin from nerve cells. [ald.org.nz]

Vindesine Poisoning

loss was seen in the peripheral nerves of these patients. [semanticscholar.org]

Myelin changes are caused by the loss of supportive role of atrophied axon for the myelin sheath. [pubmed.ncbi.nlm.nih.gov]

[…] neurology 1969 Three cases in which severe and irreversible neuropathy was associated with vincristine therapy were reported, and a varying degree of axonal degeneration and myelin [semanticscholar.org]

Charcot-Marie-Tooth Disease Type 2A1

Decreased number of peripheral myelinated nerve fibers MedGen UID: 346872 •Concept ID: C1858285 • Finding A loss of myelinated nerve fibers in the peripheral nervous system [ncbi.nlm.nih.gov]

Pseudometachromatic Leukodystrophy

Areas of hypodensity reflect loss of myelination and cerebroside accumulation.1 A "tigroid" or "leopard skin" appearance has been described, with hypointense bands (normal [scielo.org.co]

Areas of hypodensity reflect loss of myelination and cerebroside accumulation.1 A “tigroid” or “leopard skin” appearance has been described, with hypointense bands (normal [elsevier.es]

Wallerian Degeneration

The results of the in vitro time series show a progressive degeneration of the distal nerve pieces with progressive loss of myelin and axons with a simultaneous increase in [ediss.uni-goettingen.de]

It may result following neuronal loss due to cerebral infarction, trauma, necrosis, focal demyelination, or hemorrhage. [radiopaedia.org]

Wallerian degeneration is the process of antegrade degeneration of the axons and their accompanying myelin sheaths following proximal axonal or neuronal cell body lesions. [radiopaedia.org]

Yuan-Harel-Lupski Syndrome

Nerve biopsy was performed in 1 patient and showed loss of myelinated fibers and onion bulb formations. [findzebra.com]

This buildup may impair the formation of myelin. A shortage of functional PMP22 protein leads to instability and loss of myelin (demyelination). [encyclopedia.pub]

Charcot-Marie-Tooth Disease Type 4A

Motor nerve conduction velocities are decreased, and sural nerve biopsies show loss of myelinated fibers. [ncbi.nlm.nih.gov]

This results in loss of myelin and impaired nerve signal transmission. [charcot-marie-toothnews.com]

Histopathological findings associated with Q163X mutation include severe loss of myelinated axons, moderate loss of unmyelinated fibers, and onion bulb formations, with no [scielo.org.co]

Charcot-Marie-Tooth Disease Type 2B1

Charcot-Marie-Tooth Disease Type 4B2

[…] of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system. [rarediseases.oscar.ncsu.edu]

Nerve biopsy revealed myelin out-folding. [cags.org.ae]

[…] fibers Distal sensory impairment Hyporeflexia Onion bulb formation Segmental peripheral demyelination/remyelination Steppage gait Ear malformation Sensorineural hearing loss [ncbi.nlm.nih.gov]

Binswanger Disease

[…] of myelin, particularly in the periventricular regions, corona radiata, and centrum semiovale. [jaocr.org]

loss, oligodendroglial loss, microcystic cavities, myelin sheath swelling, gliosis. [learningneurology.com]

Abstract: Binswanger's disease is a subacute form of hypertensive encephalopathy characterized by patchy-confluent myelin loss of the deep hemispheric white matter, associated [content.iospress.com]

Hereditary Sensory and Autonomic Neuropathy Type 1C

Sural biopsy revealed a severe chronic axonal neuropathy with subtotal loss of myelinated axons, relatively preserved number of non-myelinated fibers and no signs for regeneration [helda.helsinki.fi]

Histopathologic examination of the specimen showed total loss of myelinated fibres and marked reduction in number of unmyelinated fibres in the sural nerve, consistent with [ijaweb.org]

Nerve biopsy with Picro-Mallory stain was suggestive of non-inflammatory neuropathy with loss of myelinated nerve fibres. [e-ijd.org]

Peroxisomal ACYL-COA Oxidase Deficiency

Destruction of myelin leads to a loss of myelin-containing tissue (white matter) in the brain and spinal cord; loss of white matter is described as leukodystrophy. [medlineplus.gov]

However, researchers suggest that the abnormal fatty acid accumulation triggers inflammation in the nervous system that leads to the breakdown of myelin, which is the covering [medlineplus.gov]