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7 Possible Causes for Loss of Myelin in the Cerebral and Cerebellar White Matter

  • Sjogren-Larsson Syndrome

    The lack of myelin may be seen in the cerebral and cerebellar white matter regions.[symptoma.com] Magnetic resonance spectroscopy (MRS) may be useful to show high lipid densities in the white matter around the ventricles.[symptoma.com] Gross examination of brain sections shows diffuse atrophy with gliosis, without any significant axonal loss.[symptoma.com]

  • Cockayne Syndrome

    cerebral and cerebellar cortices.[ncbi.nlm.nih.gov] A neuropathological examination revealed a very small brain (295 gm), extensive myelin deficiency, gliosis in the white matter, and calcifications in the basal ganglia, and[ncbi.nlm.nih.gov] The loss of both Purkinje and granular cells was noticed in the cerebellar cortex.[ncbi.nlm.nih.gov]

  • CAMFAK Syndrome

    They noted progressive cortical neuronal loss with patchy absence of myelin and gliosis in white matter, as well as pericapillary and parenchymal mineralization in the globus[ncbi.nlm.nih.gov] […] pallidus, putamen, and cerebral cortex.[ncbi.nlm.nih.gov] In older children, there was severe cerebellar degeneration involving the internal granular layer and the Purkinje cell layer, and, in the younger cases, swollen ubiquinated[ncbi.nlm.nih.gov]

  • Palpebral Nevus

    […] of speech Facial asymmetry Macrotia Ambiguous genitalia Esotropia Delayed myelination Chorea Abnormality of the cerebral white matter Irritability Muscular hypotonia of the[mendelian.co] Thin skin Split foot Alopecia of scalp Ectrodactyly Abnormality of dental morphology Dermal atrophy Conjunctivitis Finger clinodactyly Skin ulcer Sensory axonal neuropathy Loss[mendelian.co] […] trunk Micropenis Fasciculations Myoclonus Cerebellar hypoplasia Absent speech Dystonia Hypertonia Ventriculomegaly Optic atrophy Hyperreflexia Progressive microcephaly Hypergonadotropic[mendelian.co]

  • Infantile Symmetrical Thalamic Degeneration

    Cerebral white matter abnormalities consist of diffuse loss of myelin with mild gliosis and many perivascular periodic acid-Schiff-positive cells.[ajnr.org] Cerebellar involvement is common. The phenotypic expression of ALD varies widely ( 10 ).[ajnr.org]

  • Autosomal Recessive Mental Retardation 3

    The hyperintense cerebral and cerebellar white matter on T2-weighted images gradually becomes hypointense, reflecting the loss of myelin.[plaza.umin.ac.jp] The white matter volume is low and the cerebral ventricles are enlarged.[plaza.umin.ac.jp]

  • Spastic Paraplegia - Ataxia - Mental Retardation

    The hyperintense cerebral and cerebellar white matter on T2-weighted images gradually becomes hypointense, reflecting the loss of myelin.[plaza.umin.ac.jp] The white matter volume is low and the cerebral ventricles are enlarged.[plaza.umin.ac.jp]

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