Loss of Neurons: Causes & Reasons

Possible Causes for Loss of Neurons

loss in central nervous system Head tremor Abnormal pyramidal sign Neurological speech impairment Chorea Onset Rapid neurologic deterioration Abnormality of movement Fatigue [mendelian.co]

Loss of function of glucocerebrosidase GBA2 is responsible for motor neuron defects in hereditary spastic paraplegia. [ncbi.nlm.nih.gov]

They share the common features of motor and cognitive decline, epilepsy, ataxia, and vision loss with variable rate of progression ( 89 ). [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 4

Loss of motor neurons and hypercellularity due to gliosis. [neuropathology-web.org]

[…] have been reported so far) Etiology : defect in VRK1 gene on chromosome 14q → atrophy of the cerebral cortex, cerebellar and brain stem hypoplasia, absent dendate nucleus, loss [amboss.com]

[…] fibers in the fasciculus gracilis and marked loss of neurons with severe gliosis in the dentate nucleus. [emedicine.medscape.com]

Cerebral Cortical Atrophy

Atrophy of any tissue means loss of cells. In brain it means loss of neurons and the in between connections. [neuroradiologycases.com]

Atrophy of any tissue means loss of cells. In brain tissue, atrophy describes a loss of neurons and the connections between them. [ninds.nih.gov]

Spinal and Bulbar Muscular Atrophy

Loss of motor neurons and hypercellularity due to gliosis. [neuropathology-web.org]

SBMA is caused by expansion of polyglutamine in the androgen receptor (AR) and is characterized by the loss of motor neurons in the brainstem and spinal cord. [ncbi.nlm.nih.gov]

[…] of motor neurons was similar to findings in the patient with SBMA. [ncbi.nlm.nih.gov]

Upper Motor Neuron Disease

Loss of motor neurons and hypercellularity due to gliosis. [neuropathology-web.org]

Turner and Al-Chalabi 2007 Motor neurone disease comprises a number of clinical phenotypes united by the pathological feature of progressive motor neuronal loss. [mndcare.net.au]

[…] fibers in the fasciculus gracilis and marked loss of neurons with severe gliosis in the dentate nucleus. [emedicine.medscape.com]

Autosomal Recessive Primary Microcephaly Type 10

Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation. {ECO:0000269 PubMed:23178126}. [genecards.org]

Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation (summary by Yang et al., 2012 ).For a general [mendelian.co]

Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation (summary by Yang et al., 2012). [ncbi.nlm.nih.gov]

Neuronal Intranuclear Inclusion Disease

[…] intranuclear inclusions (NIT) accompanied by a more restricted pattern of neuronal loss. [experts.umich.edu]

[…] intranuclear inclusions (NII) accompanied by a more restricted pattern of neuronal loss. [ncbi.nlm.nih.gov]

Quantitative analysis of NI in the pons revealed an inverse relation of NI and cell loss, i.e. patients with more severe neuronal cell loss had a smaller proportion of neurons [rug.nl]

Neuronal Ceroid Lipofuscinosis

These progressive genetic disorders primarily manifest in the central nervous system due to an extensive loss of neurons, primarily in the cerebral and cerebellar cortices [ncbi.nlm.nih.gov]

These progressive genetic disorders primarily manifest in the central nervous system because of an extensive loss of neurons, specifically in the cerebral and cerebellar cortices [ncbi.nlm.nih.gov]

The natural substrate of TPP1 is not known, nor is the connection between storage process and neurodegeneration, which is characterized by loss of neurons. [ncbi.nlm.nih.gov]

Classic Progressive Supranuclear Palsy Syndrome

Also, results in neuronal achromasia; the severe loss of neurons, gliosis and ballooned neurons. [lecturio.com]

The clinical heterogeneity is associated with variability of regional distribution and severity of abnormal tau accumulation and neuronal loss. [ingentaconnect.com]

Neuropathologically, all forms are characterized by neuronal loss, gliosis with astrocytic plaques and accumulation of tau-immunoreactive neurofibrillary tangles in specific [orpha.net]

Neurodegenerative Disorder

Neurodegenerative disorders, which are chronic and progressive, are characterized by selective and symmetric loss of neurons in motor, sensory, or cognitive systems. [nejm.org]

Neurology A chronic progressive neuropathy characterized by selective and generally symmetrical loss of neurons in motor, sensory, or cognitive systems Types by area Cerebral [medical-dictionary.thefreedictionary.com]

Neurodegenerative disorders are illnesses characterized by a loss of nervous system functioning that are usually caused by neuronal death. [courses.lumenlearning.com]

Infantile Neuronal Ceroid Lipofuscinosis

[…] the progressive loss of thalamic neurons that relay different sensory modalities to the cortex. [ncbi.nlm.nih.gov]

It is characterized by cerebral atrophy, selective loss of cortical neurons, and secondary loss of axons and myelin sheaths of the white matter. [n.neurology.org]

Abnormal autofluorescent, electron-dense granules accumulate in the cytoplasm of nerve cells and are associated with selective destruction and loss of neurons in the brain [medlink.com]

Striatonigral Degeneration

In one case there was loss of CaN-immunoreactive neurons in the caudate nucleus to a lesser degree than that in the putamen. [ncbi.nlm.nih.gov]

SND grade II is characterized by neuronal loss, astrogliosis and presence of GCIs in SNC and posterior/dorsolateral putamen. [ncbi.nlm.nih.gov]

The dentate nucleus displayed mild loss of neurons. [dokumen.tips]

Amyotrophic Lateral Sclerosis Type 1

The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving [uniprot.org]

Pathologic features lower motor neuron signs loss of motor neurons within the anterior horns of the spinal cord and motor cranial nerve nuclei upper motor neuron signs degeneration [orthobullets.com]

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal neurodegenerative disorder that is characterized by the selective loss of motor neurons [norml.org]

Parenchymatous Cortical Cerebellar Degeneration

In brain tissue, atrophy describes a loss of neurons and the connections between them. [en.wikipedia.org]

[…] of neurons diffuse form of progressive cerebral atrophy that develops at an earlier age than the senile period CT and MRI demonstrate nonspecific findings of cerebral atrophy [quizlet.com]

These findings suggest that regional cerebral growth impairment results from interruption of cerebellocerebral connectivity and loss of neuronal activation critical for development [nature.com]

Adult-Onset Dystonia - Parkinsonism

When tested in mice, paraquat exposure led to pathological changes and loss of dopamine neurons similar to PD. [dana.org]

Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. [kobic.kr]

In advanced PD, loss of pigmented neurons results in gross depigmentation of the SN. [neuropathology-web.org]

Spinal Muscular Atrophy

Moreover, increased miR-146a was sufficient to induce motor neuron loss in vitro, whereas miR-146a inhibition prevented SMA astrocyte-induced motor neuron loss. [ncbi.nlm.nih.gov]

The loss of motor neurons causes progressive muscle weakness and loss of movement due to muscle wasting (atrophy). [rarediseases.info.nih.gov]

Spinal muscular atrophy (SMA) is an autosomal recessive genetic disorder caused by survival motor neuron (SMN) protein deficiency leading the loss of motor neurons in the [ncbi.nlm.nih.gov]

Parkinson Disease

Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. [icd9data.com]

The disease is attributed to selective loss of neurons in the substantia nigra, and its cause is enigmatic in most individuals. [ncbi.nlm.nih.gov]

It is mainly composed of structurally altered neurofilament, and occurs wherever there is excessive loss of neurons. [ncbi.nlm.nih.gov]

Idiopathic Achalasia

Abstract Idiopathic achalasia is characterized by the absence of peristalsis secondary to loss of neurons in the myenteric plexus that hampers proper relaxation of the lower [ncbi.nlm.nih.gov]

[…] of neurons in the myenteric plexu. [cipsm.de]

Abstract Idiopathic achalasia is characterized by a failure of the lower esophageal sphincter to relax due to a loss of neurons in the myenteric plexus. [ncbi.nlm.nih.gov]

Amyotrophic Lateral Sclerosis Type 11

The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving [malacards.org]

The pathological hallmarks comprise loss of motor neurons with intraneuronal ubiquitin-immunoreactive inclusions in upper motor neurons and TDP-43 immunoreactive inclusions [orpha.net]

In ALS, motor neurons die (atrophy) over time, leading to muscle weakness, a loss of muscle mass, and an inability to control movement. [malacards.org]

Olivopontocerebellar Atrophy

Both siblings had identical patterns of neuronal loss consistent with olivopontocerebellar atrophy at postmortem examination. [ncbi.nlm.nih.gov]

Postmortem examination showed typical lesions of OPCA, and on serial sections of the medulla a massive loss of neurons in the lower two thirds of the nucleus ambiguus, bilaterally [ncbi.nlm.nih.gov]

The density of GCIs does not correlate with neuronal loss in various systems. [neuropathology-web.org]

Progressive Muscular Atrophy

Loss of motor neurons and hypercellularity due to gliosis. [neuropathology-web.org]

In PMA there is gradual loss of the lower motor neurons, so the muscles become steadily weaker and more wasted, causing weakness in the area they serve. [umcutrecht.nl]

Because the upper motor neurons are not involved, those suffering from PMA may often not experience the muscular stiffness or the loss of emotional control which Motor Neurone [mndcentre.org.uk]

Lower Motor Neuron Syndrome with Late-Adult Onset

[…] fibers in the fasciculus gracilis and marked loss of neurons with severe gliosis in the dentate nucleus. [emedicine.medscape.com]

Muscle weakness Loss of motor neurons in the spinal cord In MND causes muscle weakness.[4].The earliest symptom is usually asymmetrical weakness of one extremity or, with [explainmedicine.com]

loss in the cord and brain stem- L.M. neuron loss in the cord and brain stem  - bumina bodies in surviving neuron- bumina bodies in surviving neuron  - Betz cells in motor [slideshare.net]

Postpoliomyelitis Syndrome

The main reason may be the ongoing loss of neurons over time, but other possibilities are being considered. [mjdrdypu.org]

Because polio survivors have already lost a considerable number of motor neurons, further age-related loss of neurons may contribute substantially to new muscle weakness. [en.wikipedia.org]

Rarely, persons have subclinical paralytic polio, described as a loss of motor neurons during acute polio but with no obvious deficit. [post-polio.org]

Spinal Muscular Atrophy Type 4

Loss of motor neurons leads to a loss of muscle mass, which is translated to muscle atrophy. [peripazienti.roche.it]

Loss of SMN 1 leads to a dramatic reduction in survival motor neuron (SMN) protein in the motor neurons of the spinal cord and of the brain stem. [degruyter.com]

It is caused by a loss of specialized nerve cells, called motor neurons, in the spinal cord and the part of the brain that is connected to the spinal cord (the brainstem). [checkorphan.org]

Fatal Familial Insomnia

Fatal familial insomnia is characterized by sleep disturbance and loss of neurons, with gliosis in the thalamic nuclei. [ncbi.nlm.nih.gov]

Symptoms are best understood in the context of the histopathology of FFI, primarily involving degeneration and loss of neurons in the thalamus. [enotes.com]

Histopathological examination of the dorsomedial nucleus of the thalamus shows severe loss of neuronal cells, marked astrogliosis (arrows), and rarefaction (arrowheads) of [doi.org]

Narcolepsy

Nacrolepsy is caused by the loss of neurons in the hypothalamus that specialize in the production of a hormone known as hypocretin (also known as orexin), which promotes wakefulness [britannica.com]

Neurological disorder without a cure Narcolepsy is believed to be an autoimmune neurological disorder, caused by the gradual loss of neurons (called hypocretin or orexin) [julieflygare.com]

Narcolepsy is mostly caused by the gradual loss of neurons that produce hypocretin, a hormone that keeps us awake. [scientificamerican.com]

Narcolepsy-Cataplexy Syndrome

Pathophysiological studies have shown that the disease is caused by the early loss of neurons in the hypothalamus that produce hypocretin, a wakefulness-associated neurotransmitter [ncbi.nlm.nih.gov]

Loss of hypothalamic neurons that secrete hypocretin is the underlying cause, but the mechanism remains unclear. [symptoma.com]

The exact underlying cause of this intrusion is unknown, but a loss of neurons that produce hypocretin (also known as orexin) is thought to be a major contributing factor. [medicalnewstoday.com]

Neuronal Ceroid Lipofuscinosis Type 9

It is characterized by cerebral atrophy, selective loss of cortical neurons, and secondary loss of axons and myelin sheaths of the white matter. [neurology.org]

Homozygous GRN mutations, on the other hand, lead to complete PGRN loss and cause neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease usually seen in children [scholars.northwestern.edu]

There was marked cerebral atrophy with severe neuronal and myelin loss and gliosis. [karger.com]

Juvenile Primary Lateral Sclerosis

Loss of motor neurons and hypercellularity due to gliosis. [neuropathology-web.org]

The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving [genecards.org]

Loss of motor neurons in the hypoglossal nuclei ALS, medulla. Loss of neurons in the hypoglossal nuclei. The open space at the top is the floor of the 4th ventricle. [neuropathology-web.org]

Hallervorden-Spatz Syndrome

Sections of neocortex showed mild patchy neuronal loss and occasional spheroids. [jnnp.bmj.com]

Severe neuronal loss was noted in the pars reticulata of the substantia nigra with a moderate degree of iron deposition and neuroaxonal spheroids (fig 2 D). [jnnp.bmj.com]

The pathological findings were isolated pallidal degeneration with demyelination and moderate neuronal loss, iron pigment accumulation and spheroid bodies in both pallidal [ncbi.nlm.nih.gov]