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10 Possible Causes for Lower and Upper Limbs Affected, Myoclonic Jerking, Skeletal Muscle Fasciculation

  • Amyotrophic Lateral Sclerosis

    Approximately 2/3 of patients with ALS show the spinal form of the disease (limb injuries) characterised by weakness and muscular loss in lower and upper limbs.[icm-institute.org] Sleep-related leg muscle cramps and fasciculations Degeneration of the lower motoneurons causes fasciculations in skeletal muscles which may be reported to disrupt sleep by[dovepress.com] […] and lower limbs.[ncbi.nlm.nih.gov]

  • Spinal Muscular Atrophy

    Here we report an adolescent female who presented with atonic and absence seizures and myoclonic jerks and was later diagnosed as having myoclonic-absence seizures.[ncbi.nlm.nih.gov] The lower limbs usually are affected sooner and more profoundly than are the upper limbs.[emedicine.medscape.com] Symptoms of SMA type I include hypotonia (reduced muscle tone), diminished limb movements, lack of tendon reflexes, fasciculations, swallowing and feeding difficulties, and[ninds.nih.gov]

  • Muscular Fasciculation

    jerks BFS symptoms are typically present when the muscle is at rest and are not accompanied by severe muscle weakness. [ citation needed ] In some BFS cases, fasciculations[en.wikipedia.org] Amyotrophic lateral sclerosis (ALS) both upper and lower motor neurones are affected limb muscle weakness and wasting ALS is the most common type, characterised by muscle[mndnsw.asn.au] Benign fasciculation syndrome is a mild neurological disorder that is characterized by involuntary twitching of skeletal muscles at rest.[phaa.com]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Subacute necrotizing encephalopathy, also called Leigh disease, is a lethal disorder of infancy marked by psychomotor delay, myoclonic jerks, paralyses of eye movements, and[britannica.com] Distal hereditary motor neuropathy affects nerve cells in the spinal cord and presents as weakness and wasting that starts in muscles of the upper and lower limbs and spreads[togetherinsma.com] Symptoms include fatigue, slowly progressive muscle weakness, muscle atrophy, fasciculations, cold intolerance and muscle and joint pain.[advancedpsy.com]

  • Autosomal Recessive Spastic Paraplegia Type 53

    Raymond et al (2008) noted that M-D due to SGCE mutations is characterized by early onset myoclonic jerks, often associated with dystonia.[aetna.com] OMIM : 57 SPG53 is an autosomal recessive neurologic disorder characterized by onset in infancy of delayed motor development progressing to upper and lower limb spasticity[malacards.org] It is a fatal disorder and is characterized by progressive skeletal muscle weakness and wasting or atrophy (ie, amyotrophy), spasticity, and fasciculations as a result of[emedicine.medscape.com]

  • Autosomal Dominant Spastic Paraplegia Type 41

    Raymond et al (2008) noted that M-D due to SGCE mutations is characterized by early onset myoclonic jerks, often associated with dystonia.[aetna.com] Upper limbs are often also affected, and some patients may have a subclinical axonal neuropathy (summary by Tesson et al., 2012).[malacards.org] It is a fatal disorder and is characterized by progressive skeletal muscle weakness and wasting or atrophy (ie, amyotrophy), spasticity, and fasciculations as a result of[emedicine.medscape.com]

  • Pyramidal Tract Disorder

    Subacute necrotizing encephalopathy, also called Leigh disease, is a lethal disorder of infancy marked by psychomotor delay, myoclonic jerks, paralyses of eye movements, and[britannica.com] Both upper and lower motor neurons are affected, with decreased motor strength and wasting of the muscles of the face, limbs, and diaphragm.[radiopaedia.org] Lower motor neurons in turn project via peripheral nerves to skeletal muscles. An identical concept applies to the corticobulbar tract and cranial nerve motor nuclei.[accessphysiotherapy.mhmedical.com]

  • Cataract - Ataxia - Short Stature - Mental Retardation (CASM)

    , develop next. • EEG - characteristic pattern of periodic bursts of spike-wave complexes (approximately every 5–7 sec) occurring synchronously with the myoclonic jerk. •[slideshare.net] Between 4 and 12 months of age, all patients developed progressive motor dysfunction, mainly spasticity affecting the lower limbs more than the upper limbs, as well as axial[findzebra.com] […] weakness and wasting of skeletal muscles; tongue fasciculation may aid diagnosis • Peripheral nerve * - Hereditary motor sensory neuropathies (HMSN): symmetrical wasting of[archive.org]

  • X-Linked Congenital Lower Limb Arthrogyrposis

    Raymond et al (2008) noted that M-D due to SGCE mutations is characterized by early onset myoclonic jerks, often associated with dystonia.[aetna.com] […] extremity-predominant spinal muscular atrophy-1 Muscle weakness affecting proximal lower extremities and sparing upper limbs CMT2O, malformations of cortical development,[academic.oup.com] limb anomalies congenital vertical talus congenital talipes equinovarus (bilateral) upper limb anomalies flexion deformities of the four fingers Associated conditions arthrogryphosis[orthobullets.com]

  • Transient Infantile Hypertriglyceridemia and Hepatosteatosis

    It lowers the seizure threshold in a dose-dependent manner and may induce myoclonic jerks or generalised seizures.[medicines.org.uk] […] the upper and lower limbs and associated with increased serum creatine kinase; distal muscle weakness may also occur.[mendelian.co] jerks, extrapyramidal symptoms, akathisia, tremor, rigidity, headache Uncommon: Neuroleptic malignant syndrome Rare: Confusion, delirium Very rare: Tardive dyskinesia, obsessive[medicines.org.uk]