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890 Possible Causes for Lower and Upper Limbs Affected, Onset of Symptoms in the Fourth to Sixth Decade of Life

  • Charcot-Marie-Tooth Disease Type 2S

    Clinical and electrophysiological data Limbs Onset of peripheral neuropathic symptoms was between the fourth and the sixth decades of life in five out of the seven patients[jnnp.bmj.com] Typically, this starts in the lower limbs with weakness, atrophy and deformity, and later affects the upper limbs.[radiopaedia.org] Symptoms affect both lower and upper limbs, including muscle wasting and contractures, and delayed milestones such as sitting and walking.[cmtausa.org]

  • Restless Legs Syndrome

    Although one third of patients are affected before the age of 20 years, clinical presentation typically occurs between the fourth and sixth decades of life, when sensory symptoms[content.nejm.org] Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence.[icd9data.com] A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.[icd10data.com]

  • Insect Bite

    The eruption usually presented in summer, although it occurred also at other times of the year, and predominantly affected the upper and lower limbs, although it also appeared[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Lipedema

    Primarily the lower extremities are affected, but lipedema may occur in combination with the upper extremities as well.[lymphedemablog.com] Lipedema is characterized by symmetric enlargement of the limbs, generally affecting the lower extremities extending from the hips to the ankles secondary to the deposition[lymphedemablog.com] It occasionally affects the upper limbs. Swelling may be worse in the evening or when hot. Overlying skin appears quite normal.[dermnetnz.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Pneumonia

    limbs affected more than upper limbs Muscle tone is flaccid, and the reflexes initially are brisk but then become absent; transient or occasionally persistent, coarse fasciculations[emedicine.medscape.com] […] but may develop for longer than a week; no progression of weakness should be noted after the temperature drops to normal for 48 hours; weakness is asymmetrical, with the lower[emedicine.medscape.com]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Coagulation Abnormalities

    The VM affected an upper limb in 12 patients, a lower limb in 10 and both in two.[ncbi.nlm.nih.gov] A homogenous group of 24 patients with diffuse limb VM was entered into a retrospective chart review study.[ncbi.nlm.nih.gov]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Herpes Zoster

    upper and lower limb or abdominal musculature. 1 The prevalence of motor involvement is about 0.17% among patients with herpes zoster. 2 Abdominal or flank bulges typically[cmaj.ca] Classically, reactivation of herpes zoster infection affects sensory nerve roots; however, it may extend to motor involvement, which can include paresis of diaphragmatic,[cmaj.ca]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Medial Sclerosis

    Imaging Affected medium-sized arteries in the upper and lower limbs have linear low power H&E stained cross section of artery with medial calcific sclerosis calcifications[newmedicalterms.com] Imaging Affected medium-sized arteries in the upper and lower limbs have linear calcifications, resulting in a so-called pipestem appearance.[medical-dictionary.thefreedictionary.com] It is frequent to found ulcers of arterial type in the upper and lower limbs of distal predominance, so serious that sometimes may require amputation of the extremity to control[elsevier.es]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Arthritis of Knee

    It affects multiple joints in the upper and well as the lower limbs. Knees are one of the common joints affected by RA.[news-medical.net]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life
  • Entrapment Neuropathy

    Syndromes [ edit ] Upper limb Lower limb, abdomen and pelvis Signs/symptoms [ edit ] Tingling, numbness, and/ or a burning sensation in the area of the body affected by the[en.wikipedia.org]

    Missing: Onset of Symptoms in the Fourth to Sixth Decade of Life

Further symptoms