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11 Possible Causes for Lower Extremity Cellulitis, Mixed Connective Tissue Disease

  • Edema

    Bilateral lower extremity edema Bilateral Edema Nonpitting Pitting Nontender Tender Fast Slow LowLymphedema Venous protein hypertension state Elevated neck veins?[] Leg Swelling: Symptom of Pitting Edema Leg swelling generally occurs because of an abnormal accumulation of fluid in the tissues of the lower extremity.[] Picture of Pitting Edema Leg Swelling: Symptom of Pitting Edema Leg swelling generally occurs because of an abnormal accumulation of fluid in the tissues of the lower extremity[]

  • Varicose Ulcer

    Compression therapy helps prevent reflux, decreases release of inflammatory cytokines, and reduces fluid leakage from capillaries, thereby controlling lower extremity edema[] Mixed connective tissue disease (MCTD) MCTD is an overlap syndrome combining features of SLE, RA, systemic sclerosis, and dermatomyositis together with the presence of antibodies[] Associated findings include lower extremity varicosities, edema, venous dermatitis, and lipodermatosclerosis.[]

  • Bacterial Myositis

    Penetration along facial planes can occur, followed by thrombophlebitis in the lower extremities, bacteremia with metastatic abscesses and rapid death.[] DM usually occurs alone but may overlap with scleroderma and mixed connective tissue disease.[] tissue diseases Yes a Scleroderma and mixed connective tissue disease (overlap syndromes) Yes, in up to ...[]

  • Proliferating Angioendotheliomatosis

    Some cases have been mistaken for cellulitis or vascular tumors such as angiosarcomas or Kaposi’s sarcoma. The lower extremities are the most commonly affected site.[] Abstract quote A 55-year-old white female with a complex medical history including mixed connective tissue disease and peripheral vascular disease developed a group of red-purple[]

  • Acute Polyarticular Gouty Arthritis

    The hallmarks include: Sudden and rapid onset of severe pain, often in a lower extremity at first Stiffness and swelling of the affected joint, including inability to bear[] Arthritis Rheum 33:1753–1762 PubMed CrossRef Google Scholar Reichlin M (2005) Undifferentiated connective tissue disease, overlap syndromes, and mixed connective tissue diseases[] Fever, leukocytosis, and localized erythema may lead to erroneous consideration of cellulitis or thrombophlebitis (when the distal lower extremity is involved). — Chronic[]

  • Penile Cellulitis

    : common in morbidly obese patients Perianal cellulitis: sharply demarcated, bright, perianal erythema Necrotizing cellulitis: gas-producing bacteria in the lower extremities[] Cutis Laxa Dermatomyositis Dupuytren Contracture Homocystinuria Marfan Syndrome Mixed Connective Tissue Disease Noonan Syndrome Osteopoikilosis Penile Induration Pseudoxanthoma[] : Cellulitis recurrence score (predicts recurrence of lower extremity cellulitis based on presence of lymphedema, chronic venous insufficiency, peripheral vascular disease[]

  • Hypogammaglobulinemia

    He had experienced multiple episodes of lower extremity cellulitis, left more frequent than right leg, beginning in childhood.[] (LAD) Lupus (SLE) Lyme disease, chronic Meniere’s disease Microscopic polyangiitis Mixed connective tissue disease (MCTD) Polyarteritis nodosa Type I, II, & III autoimmune[] Type 1 diabetes) Juvenile myositis Kawasaki syndrome Lambert-Eaton syndrome Leukocytoclastic vasculitis Lichen planus Lichen sclerosus Ligneous conjunctivitis Linear IgA disease[]

  • Lymphedema Hypoparathyroidism Syndrome

    The right lower extremity is preferentially involved. Generally, the edema involves the dorsum of the foot and does not extend beyond the level of the knee.[] (MD) 7 50 57 Mental Retardation 36 5 41 Microcephaly 31 0 31 Migraine 117 926 1043 Mitochondrial Disease 77 44 121 Mixed Connective Tissue Disease (MCTD) 3 89 92 Moebius[] connective tissue disease Molar pregnancy Molluscum contagiosum Monoclonal gammopathy of undetermined significance (MGUS) Mononucleosis Morton's neuroma Motion sickness Mucormycosis[]

  • Carcinomatous Myopathic Syndrome

    Hypertrophic osteoarthropathy masquerading as lower extremity cellulitis and response to bisphosphonates. J Thorac Oncol 2009; 4(2): 260-2. [ PubMed ] 28. Ali N, et al.[] NB: can overlap with other connective tissue disease eg. mixed connective tissue disease Other connective tissue disease eg. SLE, vasculitis, RA, systemic sclerosis.[] connective tissue disease (MCTD)/Undifferentiated Polymyositis Isaacs potassium channel myopathy syndrome Myositis synthetase syndrome/Anti-Jo-1 syndrome Metabolic/Storage[]

  • Subcutaneous Tissue Disease

    Staph aureus -historically, most common on face, now 70-80% are on the lower extremities -painful lesion with bright red, edematous, indurated appearance *sharply demarcated[] This is the first case of the presence of metaplastic bone formation in a patient with mixed connective tissue disease.[] (MIXED CONNECTIVE TISSUE DISEASE MCTD ) 2,704 results Pregnancy outcomes in mixed connective tissue disease: a multicentre study.[]

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