Lower Extremity Pain: Possible Causes & Differential Diagnoses

Lower Extremity Arteriosclerosis
Lower Extremity Pain Leg Pain
Sciatic Neuropathy
Lower Extremity Pain

Patients with SN typically present with lower extremity pain and paresthesias.^[1]
Morbid Obesity
Lower Extremity Pain

Morbid obesity or clinically severe obesity is a condition characterized by body mass index (BMI) over 40 kg/m2, and involves serious health consequences. Morbid obesity is associated with a number of comorbidities that enhance the risk of mortality. Weight problems with symptoms of associated complications are the…^[2]
Malignant Glioma
Lower Extremity Pain

Malignant glioma is the most common type of primary brain tumor. It is characterized by highly aggressive and invasive growth, which leads to a progressive destruction of brain tissue. Recurrence after surgical resection is likely and the patients' prognosis is poor. Patients suffering from malignant glioma may…^[3]
Hypervitaminosis A
Lower Extremity Pain

Hypervitaminosis A refers to the toxic effects of ingesting too much preformed vitamin A. Symptoms arise as a result of altered bone metabolism and altered metabolism of other fat-soluble vitamins. Hypervitaminosis A is believed to have occurred in early humans, and the problem has persisted throughout human…^[4]
Juxtacortical Osteosarcoma
Lower Extremity Pain
Schmid Metaphyseal Chondrodysplasia
Lower Extremity Pain

Schmid metaphyseal chondrodysplasia is a type of chondrodysplasia associated with a deficiency of collagen, type X, alpha 1. Unlike other "rickets syndromes", affected individuals have normal serum calcium, phosphorus, and urinary amino acid levels. Long bones are short and curved, with widened growth plates and…^[5]
Hereditary Lymphedema
Unilateral Edema of the Lower Extremity Lower Extremity Pain

Milroy's disease (MD) is a familial disease characterized by lymphedema, commonly in the legs, caused by congenital abnormalities in the lymphatic system. Disruption of the normal drainage of lymph leads to fluid accumulation and hypertrophy of soft tissues. It is also known as Milroy disease, Nonne-Milroy-Meige syndrome…^[6]
Peripheral Neuropathy
Lower Extremity Pain

Peripheral neuropathy refers to damage to one or more than one nerves which results in gradual axonal damage and disturbed functioning. Presentation varies with the type of neuropathy. Sensory neuropathy presents with asymmetric or symmetric numbness, tingling, parasthesia, tremors and a disturbed gait. Motor…^[7]
Myelopathy
Lower Extremity Pain

Myelopathy is an umbrella term for various problems affecting the spinal region. Myelopathy may present with neck stiffness along with severe pain in the either one or both sides of the neck. The pain and associated stiffness may radiate to the arms and shoulders. Individuals suffering from myelopathy, experience…^[8]

Possible Causes for Lower Extremity Pain in USA

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