Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity.
[ebi.ac.uk]
Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness
[asperbio.com]
lower extremities, spasticity is increased at the hamstrings, quadriceps and ankles Weakness is most notable at the iliopsoas, tibialis anterior, hamstring muscles difficulty
[slideshare.net]