Lower Extremity Spasticity: Causes & Reasons

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Possible Causes for Lower Extremity Spasticity

Autosomal Dominant Spastic Paraplegia Type 10

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd9data.com]

Pure HSPs are characterized by slowly progressive lower extremity spasticity and weakness, often associated with hypertonic urinary disturbances, mild reduction of lower extremity [medicbind.com]

Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. [icd9data.com]

Autosomal Dominant Spastic Paraplegia Type 4

lower extremity spasticity and weakness, with either autosomal dominant and recessive or X-linked pattern of inheritance. [link.springer.com]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [ebi.ac.uk]

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Autosomal Dominant Spastic Paraplegia Type 6

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [ebi.ac.uk]

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive, lower extremity spasticity caused by axonal degeneration [genecards.org]

Autosomal Dominant Spastic Paraplegia Type 31

[…] genetically diverse syndromes characterized by insidiously progressive lower extremity spasticity. [neurology.org]

[…] characterized by a pure phenotype of proximal weakness of the lower extremities with spastic gait and brisk reflexes, with a bimodal age of onset of either childhood or adulthood [orpha.net]

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

Autosomal Dominant Spastic Paraplegia Type 8

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [ebi.ac.uk]

lower extremities, spasticity is increased at the hamstrings, quadriceps and ankles  Weakness is most notable at the iliopsoas, tibialis anterior, hamstring muscles  difficulty [slideshare.net]

X-Linked Spastic Paraplegia Type 2

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [connects.catalyst.harvard.edu]

HSP) are a rare, heterogeneous group of inherited neurodegenerative diseases characterized by progressive lower extremity spasticity and weakness. [n.neurology.org]

The hereditary spastic paraplegias are a group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity; see [diseaseinfosearch.org]

Autosomal Recessive Spastic Paraplegia Type 18

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd10data.com]

extremity weakness and spasticity. [cags.org.ae]

X-linked Spastic Paraplegia Type 16

extremity spasticity; see reviews of {5:Fink et al. (1996)} and {4:Fink (1997)}. [diseaseinfosearch.org]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [reference.md]

Autosomal Recessive Spastic Paraplegia Type 20

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [reference.md]

Autosomal Recessive Spastic Paraplegia Type 26

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [reference.md]

Autosomal Recessive Spastic Paraplegia Type 46

HSP clinical syndromes may be limited to difficulty walking due to lower extremity spastic weakness (“uncomplicated HSP”) or may include other neurologic or systemic disturbances [mhmedical.com]

All forms of HSP, complicated and uncomplicated, share the primary symptom of lower-extremity spastic weakness. [invitae.com]

Spastic paraplegia is a group of clinically and genetically heterogeneous neurodegenerative disorders characterized by lower extremity spasticity and weakness. [blueprintgenetics.com]

Autosomal Dominant Spastic Paraplegia Type 17

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Autosomal Dominant Spastic Paraplegia Type 13

Abstract: Hereditary spastic paraplegia (HSP) is a genetically heterogeneous group of neurodegenerative disorders characterized by progressive lower extremity weakness and [deepblue.lib.umich.edu]

Autosomal Dominant Spastic Paraplegia Type 19

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [reference.md]

Autosomal Recessive Spastic Paraplegia Type 14

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd10data.com]

Autosomal Recessive Spastic Paraplegia Type 44

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

All forms of HSP, complicated and uncomplicated, share the primary symptom of lower-extremity spastic weakness. [invitae.com]

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Autosomal Dominant Spastic Paraplegia Type 29

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

[updated Aug. 2017 by FlyBase; FBrf0222196 ] Disease Summary Information Parent Disease Summary: spastic paraplegia Symptoms and phenotype The hereditary spastic paraplegias [flybase.org]

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Autosomal Recessive Spastic Paraplegia Type 7

Pure types involving the lower extremities. Complex types involving the lower extremities and may affect the upper extremities to a lesser degree. [ivami.com]

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Autosomal Dominant Spastic Paraplegia Type 12

[…] genetically diverse syndromes characterized by insidiously progressive lower extremity spasticity. [neurology.org]

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

Autosomal Recessive Spastic Paraplegia Type 28

All forms of HSP, complicated and uncomplicated, share the primary symptom of lower-extremity spastic weakness. [invitae.com]

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Autosomal Dominant Spastic Paraplegia Type 37

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Spastic paraplegia is a group of clinically and genetically heterogeneous neurodegenerative disorders characterized by lower extremity spasticity and weakness. [blueprintgenetics.com]

Autosomal Recessive Spastic Paraplegia Type 27

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

[…] predominantly in the lower extremities with weakness, spasticity and hyperreflexia, and bilateral extensor plantar response. [ajnr.org]

Autosomal Recessive Spastic Paraplegia Type 48

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Hereditary spastic paraplegia (HSP) is characterized by progressive lower extremity weakness and spasticity, and may present with prominent peripheral neuropathy as one of [neurology.testcatalog.org]

lower extremity-predominant spinal muscular atrophy type 2 AD 13 BSCL2 606158 Lipodystrophy, congenital generalized, type 2; spastic paraplegia 17; Neuropathy, distal hereditary [centogene.com]

Autosomal Recessive Spastic Paraplegia Type 32

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

[…] of lower extremity vibration sense and proprioception. [ng.neurology.org]

Autosomal Recessive Spastic Paraplegia Type 45

[…] characterized predominantly by progressive lower extremity spasticity and weakness. [diseaseinfosearch.org]

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

“Complicated” HSP is the diagnosis given to an individual who suffers with lower extremity spasticity along with such neurological problems as peripheral neuropathy, seizures [medschool.lsuhsc.edu]

Autosomal Recessive Spastic Ataxia Type 2

[…] of lower extremity vibration sense and proprioception. [ng.neurology.org]

Hereditary spastic paraplegia type 18 (HSP18) is a complicated form of autosomal recessive HSP characterized by progressive weakness and spasticity of the lower extremities [hspersunite.org.au]

[…] of the lower extremities (pure or uncomplicated HSPs). [els.net]

Autosomal Dominant Spastic Paraplegia Type 9A

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

[…] predominantly in the lower extremities with weakness, spasticity and hyperreflexia, and bilateral extensor plantar response. [ajnr.org]

The thoracic spinal cord focally protrudes through a defect in the dura, resulting in progressive weakness, numbness, and spasticity affecting the lower extremities, in addition [readbyqxmd.com]

Autosomal Dominant Spastic Paraplegia Type 36

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Given that both of these disorders are treatable, dopa-responsive dystonia should be excluded in a child with progressive gait disturbance and lower-extremity spasticity of [emedicine.medscape.com]

[…] predominantly in the lower extremities with weakness, spasticity and hyperreflexia, and bilateral extensor plantar response. [ajnr.org]

Autosomal Dominant Spastic Paraplegia Type 33

lower extremity spasticity and weakness, with either autosomal dominant and recessive or X-linked pattern of inheritance. [link.springer.com]

[…] characterized by progressive lower extremity weakness and spasticity. [pdfs.semanticscholar.org]

Spastic Paraplegia - Ataxia - Mental Retardation

extremity spasticity; see reviews of {5:Fink et al. (1996)} and {4:Fink (1997)}. [diseaseinfosearch.org]

Abstract Hereditary spastic paraplegia (HSP) is a diverse group of inherited disorders characterized by progressive lower-extremity spasticity and weakness. [neurology.org]