Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity.
[ebi.ac.uk]
Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive, lower extremity spasticity caused by axonal degeneration
[genecards.org]
lower extremities, spasticity is increased at the hamstrings, quadriceps and ankles Weakness is most notable at the iliopsoas, tibialis anterior, hamstring muscles difficulty
[slideshare.net]