Lower-extremity-spasticity: Causes & Reasons

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Possible Causes for lower extremity spasticity

Autosomal Dominant Spastic Paraplegia Type 10

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd9data.com]

Pure HSPs are characterized by slowly progressive lower extremity spasticity and weakness, often associated with hypertonic urinary disturbances, mild reduction of lower extremity [medicbind.com]

Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. [icd9data.com]

Autosomal Dominant Spastic Paraplegia Type 6

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [ebi.ac.uk]

Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive, lower extremity spasticity caused by axonal degeneration [genecards.org]

Autosomal Dominant Spastic Paraplegia Type 4

lower extremity spasticity and weakness, with either autosomal dominant and recessive or X-linked pattern of inheritance. [link.springer.com]

[…] characterized predominantly by progressive lower extremity spasticity and weakness. [diseaseinfosearch.org]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [ebi.ac.uk]

Autosomal Dominant Spastic Paraplegia Type 8

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [ebi.ac.uk]

Clinical Features  Symptoms depend on the type of HSP inherited  Main feature progressive spasticity in the lower limbs, due to pyramidal tract dysfunction  In the lower [slideshare.net]

Autosomal Dominant Spastic Paraplegia Type 31

[…] characterized by a pure phenotype of proximal weakness of the lower extremities with spastic gait and brisk reflexes, with a bimodal age of onset of either childhood or adulthood [orpha.net]

[…] by insidiously progressive lower extremity spasticity. [neurology.org]

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

X-Linked Spastic Paraplegia Type 2

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [connects.catalyst.harvard.edu]

HSP) are a rare, heterogeneous group of inherited neurodegenerative diseases characterized by progressive lower extremity spasticity and weakness. [n.neurology.org]

The hereditary spastic paraplegias are a group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity; see [diseaseinfosearch.org]

X-linked Spastic Paraplegia Type 16

extremity spasticity; see reviews of {5:Fink et al. (1996)} and {4:Fink (1997)}. [diseaseinfosearch.org]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [reference.md]

Autosomal Recessive Spastic Paraplegia Type 20

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd10data.com]

Autosomal Recessive Spastic Paraplegia Type 18

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd10data.com]

extremity weakness and spasticity. [cags.org.ae]

Autosomal Recessive Spastic Paraplegia Type 26

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [reference.md]

Autosomal Recessive Spastic Paraplegia Type 46

HSP clinical syndromes may be limited to difficulty walking due to lower extremity spastic weakness (“uncomplicated HSP”) or may include other neurologic or systemic disturbances [mhmedical.com]

All forms of HSP, complicated and uncomplicated, share the primary symptom of lower-extremity spastic weakness. [invitae.com]

Spastic paraplegia is a group of clinically and genetically heterogeneous neurodegenerative disorders characterized by lower extremity spasticity and weakness. [blueprintgenetics.com]

Autosomal Dominant Spastic Paraplegia Type 17

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Autosomal Dominant Spastic Paraplegia Type 13

All forms of HSP, complicated and uncomplicated, share the primary symptom of lower-extremity spastic weakness. [invitae.com]

Autosomal Recessive Spastic Paraplegia Type 14

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd10data.com]

Autosomal Dominant Spastic Paraplegia Type 19

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd10data.com]

Autosomal Dominant Spastic Paraplegia Type 29

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

[updated Aug. 2017 by FlyBase; FBrf0222196 ] Disease Summary Information Parent Disease Summary: spastic paraplegia Symptoms and phenotype The hereditary spastic paraplegias [flybase.org]

All forms of HSP, complicated and uncomplicated, share the primary symptom of lower-extremity spastic weakness. [invitae.com]

Autosomal Recessive Spastic Paraplegia Type 44

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

All forms of HSP, complicated and uncomplicated, share the primary symptom of lower-extremity spastic weakness. [invitae.com]

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Autosomal Dominant Spastic Paraplegia Type 12

[…] by insidiously progressive lower extremity spasticity. [neurology.org]

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

Autosomal Dominant Spastic Paraplegia Type 37

Genetic counseling Hereditary Spastic Paraplegia (HSP) is a group of clinically and genetically heterogeneous disorders characterized by lower extremity spasticity and weakness [asperbio.com]

Spastic paraplegia is a group of clinically and genetically heterogeneous neurodegenerative disorders characterized by lower extremity spasticity and weakness. [blueprintgenetics.com]

Autosomal Recessive Spastic Paraplegia Type 7

Pure types involving the lower extremities. Complex types involving the lower extremities and may affect the upper extremities to a lesser degree. [ivami.com]

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Autosomal Recessive Spastic Paraplegia Type 28

All forms of HSP, complicated and uncomplicated, share the primary symptom of lower-extremity spastic weakness. [invitae.com]

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Autosomal Recessive Spastic Paraplegia Type 32

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

[…] of lower extremity vibration sense and proprioception. [ng.neurology.org]

Autosomal Recessive Spastic Paraplegia Type 27

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

[…] predominantly in the lower extremities with weakness, spasticity and hyperreflexia, and bilateral extensor plantar response. [ajnr.org]

Autosomal Recessive Spastic Paraplegia Type 48

On examination, the patient exhibited prominent lower extremity spasticity with mild distal muscle weakness and mild weakness of the hip flexors. Cognition was intact. [ng.neurology.org]

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Hereditary spastic paraplegia (HSP) is characterized by progressive lower extremity weakness and spasticity, and may present with prominent peripheral neuropathy as one of [neurology.testcatalog.org]

Autosomal Recessive Spastic Paraplegia Type 45

[…] characterized predominantly by progressive lower extremity spasticity and weakness. [diseaseinfosearch.org]

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

“Complicated” HSP is the diagnosis given to an individual who suffers with lower extremity spasticity along with such neurological problems as peripheral neuropathy, seizures [medschool.lsuhsc.edu]

Autosomal Dominant Spastic Paraplegia Type 36

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

Given that both of these disorders are treatable, dopa-responsive dystonia should be excluded in a child with progressive gait disturbance and lower-extremity spasticity of [emedicine.medscape.com]

[…] predominantly in the lower extremities with weakness, spasticity and hyperreflexia, and bilateral extensor plantar response. [ajnr.org]

Autosomal Recessive Spastic Ataxia Type 2

[…] of lower extremity vibration sense and proprioception. [ng.neurology.org]

Hereditary spastic paraplegia type 18 (HSP18) is a complicated form of autosomal recessive HSP characterized by progressive weakness and spasticity of the lower extremities [hspersunite.org.au]

[…] of the lower extremities (pure or uncomplicated HSPs). [els.net]

Autosomal Dominant Spastic Paraplegia Type 9A

lower extremity spasticity and weakness and other common symptoms Individuals without a positive family history, but with symptoms resembling hereditary spastic paraplegia [centogene.com]

[…] predominantly in the lower extremities with weakness, spasticity and hyperreflexia, and bilateral extensor plantar response. [ajnr.org]

The thoracic spinal cord focally protrudes through a defect in the dura, resulting in progressive weakness, numbness, and spasticity affecting the lower extremities, in addition [readbyqxmd.com]

Spastic Paraplegia

Introduction to the disease The hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder that characterized by lower extremity spasticity [medicaljoyworks.com]

(SPG, HSP) are a large group of clinically and genetically diverse disorders characterized by progressive, usually severe, lower extremity spasticity and weakness. [flybase.org]

Abstract Hereditary spastic paraplegia (HSP) is a diverse group of inherited disorders characterized by progressive lower-extremity spasticity and weakness. [n.neurology.org]

Hereditary Spastic Paraplegia

It is characterized by progressive lower extremity spasticity and weakness, dysarthria, distal amyotrophy, developmental delay, short stature, and subtle skeletal abnormalities [ncbi.nlm.nih.gov]

Hereditary spastic paraplegias are a clinically and genetically heterogeneous group of disorders characterized by lower extremity spasticity and weakness. [ncbi.nlm.nih.gov]

Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. [icd9data.com]