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69 Possible Causes for Lower Limb Weakness as Presenting Feature

  • Hyperventilation

    A five-months-pregnant female of the age 25 years presented with sudden onset flaccid weakness of both lower limbs associated with thigh muscle pain followed by weakness of[ncbi.nlm.nih.gov] However, the resultant hypokalaemia in respiratory alkalosis is usually mild and does not cause much clinical features.[ncbi.nlm.nih.gov]

  • Pleomorphic Xanthoastrocytoma

    Case Report A 55-year-old male presented with weakness and numbness of right upper and lower limbs since 3 months.[ccij-online.org] The present case was of a 55-year-old male who presented with weakness and numbness of right upper and lower limbs since 3 months along with difficulty in walking as well[ccij-online.org] We herein report an extremely rare case of synchronous, multicentric PXA with anaplastic features in a 55-year-old male.[ccij-online.org]

  • Gitelman Syndrome

    It was noted that in this pedigree, only the proband complained about recurrent episodes of bilateral lower limb weakness over 8 years, while his elder sister, mother and[ncbi.nlm.nih.gov] […] daughter did not present symptoms.[ncbi.nlm.nih.gov] The inconsistent clinical features of this pedigree implied that besides diverse phenotypes possibly originated from the same genotype, gender difference may also dominate[ncbi.nlm.nih.gov]

  • Pilomyxoid Astrocytoma

    Clinical Summary A six-year-old boy presented with vomiting, increasing head size, altered sensorium, weakness of lower limbs, loss of appetite and loss of weight.[ijpmonline.org] Rarity of this lesion prompted us to present the clinico-radiological and pathological features of this case.[ijpmonline.org]

  • Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset

    Distinguishing the Cause of Muscle Weakness: Lower Motor Neuron Dysfunction vs Myopathy* Feature Lower Motor Neuron Dysfunction Myopathy* Distribution of weakness Distal proximal[msdmanuals.com] Distinguishing Upper From Lower Motor Neuron Lesions Feature Upper Lesion Lower Lesion Reflexes Hyperactive Diminished or absent Atrophy Absent* Present Fasciculations Absent[msdmanuals.com] Present Tone Increased Decreased or absent *May appear with prolonged disuse of limbs.[msdmanuals.com]

  • Progressive Bulbar Palsy

    Distinguishing the Cause of Muscle Weakness: Lower Motor Neuron Dysfunction vs Myopathy* Feature Lower Motor Neuron Dysfunction Myopathy* Distribution of weakness Distal proximal[merckmanuals.com] Distinguishing Upper From Lower Motor Neuron Lesions Feature Upper Lesion Lower Lesion Reflexes Hyperactive Diminished or absent Atrophy Absent* Present Fasciculations Absent[merckmanuals.com] Present Tone Increased Decreased or absent *May appear with prolonged disuse of limbs.[merckmanuals.com]

  • Motor Neuron Disease

    Distinguishing the Cause of Muscle Weakness: Lower Motor Neuron Dysfunction vs Myopathy* Feature Lower Motor Neuron Dysfunction Myopathy* Distribution of weakness Distal proximal[merckmanuals.com] Distinguishing Upper From Lower Motor Neuron Lesions Feature Upper Lesion Lower Lesion Reflexes Hyperactive Diminished or absent Atrophy Absent* Present Fasciculations Absent[merckmanuals.com] Present Tone Increased Decreased or absent *May appear with prolonged disuse of limbs.[merckmanuals.com]

  • Upper Motor Neuron Disease

    Distinguishing the Cause of Muscle Weakness: Lower Motor Neuron Dysfunction vs Myopathy* Feature Lower Motor Neuron Dysfunction Myopathy* Distribution of weakness Distal proximal[msdmanuals.com] Distinguishing Upper From Lower Motor Neuron Lesions Feature Upper Lesion Lower Lesion Reflexes Hyperactive Diminished or absent Atrophy Absent* Present Fasciculations Absent[msdmanuals.com] Present Tone Increased Decreased or absent *May appear with prolonged disuse of limbs.[msdmanuals.com]

  • Amyotrophic Lateral Sclerosis

    Distinguishing the Cause of Muscle Weakness: Lower Motor Neuron Dysfunction vs Myopathy* Feature Lower Motor Neuron Dysfunction Myopathy* Distribution of weakness Distal proximal[merckmanuals.com] […] of lower limbs.[doi.org] Distinguishing Upper From Lower Motor Neuron Lesions Feature Upper Lesion Lower Lesion Reflexes Hyperactive Diminished or absent Atrophy Absent* Present Fasciculations Absent[merckmanuals.com]

  • Amyotrophic Lateral Sclerosis Type 1

    ; Supportive care Weakness Patterns of weakness & dysfunction: Common features 40 Limb weakness Early patterns Asymmetric May involve proximal or distal musculature Specific[neuromuscular.wustl.edu] […] patterns Upper Lower extremity (Flail arm) Higher frequency in patients of African descent Male Female More common in younger patients Longer survival Distal lower extremity[neuromuscular.wustl.edu] […] years Survival: Intermediate Median: 32 months (23 to 48 months) 5 years: 20% 10 years: 5% to 10% Shorter: Bulbar onset Longer: Earlier onset age; ALS family history; PLS presentation[neuromuscular.wustl.edu]

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