Lower Motor Neuron Degeneration: Causes & Reasons

Possible Causes for Lower Motor Neuron Degeneration

Motor Neurone Disease Motor Neurone Disease (MND) is a progressive neurodegenerative disease that attacks the upper and lower motor neurones. [bournemouthphysiotherapy.co.uk]

Upper motor neuron degeneration generally causes spasticity (tightness in a muscle), slowness of movement, poor balance and incoordination, while lower motor neuron degeneration [mda.org]

A physical exam typically finds different signs and symptoms depending on whether you have upper or/and lower motor neuron degeneration. [web.alsa.org]

Amyotrophic Lateral Sclerosis Type 1

El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis 7 : it requires the presence of signs of lower motor neuron (LMN) degeneration by clinical, electrophysiological [radiopaedia.org]

Lower motor neuron degeneration usually appears within three to five years in these patients. [rarediseases.org]

It classifies diagnosis into four different categories depending on severity of upper (UMN) as well as lower motor neuron (LMN) degeneration (which must not be explained by [physio-pedia.com]

Autosomal Recessive Spastic Paraplegia Type 63

CYP7B1 mutations are responsible for rare forms of liver failure in infancy as well as lower motor neuron degeneration in adults with no obvious genotype-phenotype correlation [oxfordmedicine.com]

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [cambridge.org]

Autosomal Recessive Spastic Paraplegia Type 39

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [ghr.nlm.nih.gov]

Autosomal Recessive Spastic Paraplegia Type 18

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [cambridge.org]

Autosomal Recessive Spastic Paraplegia Type 48

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [cambridge.org]

Autosomal Recessive Spastic Paraplegia Type 44

motor neuron degeneration. [els.net]

neuron degeneration. [nature.com]

Amyotrophic Lateral Sclerosis Type 6

Postmortem analysis of three cases with FUS mutations showed FUS-immunoreactive cytoplasmic inclusions and predominantly lower motor neuron degeneration. [researchers.mq.edu.au]

Autosomal Recessive Spastic Paraplegia Type 46

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [cambridge.org]

motor neuron degeneration. [omicsonline.org]

Denora P, Boukhris A, Tazir M, et al. (2008) Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower [omicsonline.org]

Primary Lateral Sclerosis

[…] involvement of lower motor neurons. [ncbi.nlm.nih.gov]

Â The area that is affected is the corticospinal system without the involvement of lower motor neurons unlike in ALS wherein lower motor neuron degeneration occurs in all [differencebetween.net]

In this patient, the upper motor neuron system, including the precentral cortex and descending pyramidal tract, was severely degenerated, but the lower motor neurons and innervated [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 4

CONCLUSION: Genetic mapping of a novel rare phenotype of lower motor neuron disease opens the way toward the identification of a new gene involved in motor neuron degeneration [ncbi.nlm.nih.gov]

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Conclusion: Genetic mapping of a novel rare phenotype of lower motor neuron disease opens the way toward the identification of a new gene involved in motor neuron degeneration [neurology.org]

Amyotrophic Lateral Sclerosis Type 4

Those criteria are as follows: Clinical evidence of upper motor neuron degeneration Clinical, electrophysiological, or neuropathological evidence of lower motor neuron degeneration [symptoma.com]

El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis 7 : it requires the presence of signs of lower motor neurone (LMN) degeneration by clinical, electrophysiological [radiopaedia.org]

There is a progressive loss of motor strength, with preservation of intellectual and sensory function. [radiopaedia.org]

Amyotrophic Lateral Sclerosis Type 7

[…] and lower motor neuron degeneration. [neurologyindia.com]

Progressive upper and lower motor neuron signs are also seen in a group of juvenile onset motor neuron disorders with different clinical and genetic patterns. [neurologyindia.com]

Amyotrophic Lateral Sclerosis Type 5

[…] and lower motor neuron degeneration. [neurologyindia.com]

Progressive upper and lower motor neuron signs are also seen in a group of juvenile onset motor neuron disorders with different clinical and genetic patterns. [neurologyindia.com]

Autosomal Recessive Spastic Paraplegia Type 28

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [cambridge.org]

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus collosum, cognitive decline and lower motor neuron degeneration. [1pdf.net]

Amyotrophic Lateral Sclerosis

motor neuron degeneration, particularly in the early symptomatic stages of ALS. [ncbi.nlm.nih.gov]

ALS causes both the upper and lower motor neurons to degenerate or die. [web.archive.org]

Amyotrophic Lateral Sclerosis Type 3

[…] and lower motor neuron degeneration. [neurologyindia.com]

El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis 7: it requires the presence of signs of lower motor neuron (LMN) degeneration by clinical, electrophysiological [radiopaedia.org]

Amyotrophic Lateral Sclerosis Type 10

Physical findings: In ALS, both the upper motor neurons and the lower motor neurons degenerate or die, ceasing to send messages to muscles. [secure.ssa.gov]

Amyotrophic Lateral Sclerosis Type 11

[…] in degenerating lower motor neurons. [orpha.net]

The pathological hallmarks comprise loss of motor neurons with intraneuronal ubiquitin-immunoreactive inclusions in upper motor neurons and TDP-43 immunoreactive inclusions [orpha.net]

Progressive Muscular Atrophy

[…] in ALS it was the upper motor neurone degeneration that was primary, with lower motor neurone degeneration being secondary. [en.wikipedia.org]

[…] and sporadic motor neuron disorder characterized by clinically isolated lower motor neuron degeneration. [5] A few case reports about the use of sugammadex in patients with [journals.lww.com]

Focality of upper and lower motor neuron degeneration at the clinical onset of ALS. Neurology 2007;68:1571-5. Ravits JM, La Spada AR. [acnr.co.uk]

Autosomal Recessive Spastic Paraplegia Type 21

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [cambridge.org]

motor neuron degeneration. [omicsonline.org]

Denora P, Boukhris A, Tazir M, et al. (2008) Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower [omicsonline.org]

Autosomal Recessive Spastic Paraplegia Type 14

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [cambridge.org]

motor neuron degeneration. [omicsonline.org]

Denora P, Boukhris A, Tazir M, et al. (2008) Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower [omicsonline.org]

Infantile-Onset Ascending Hereditary Spastic Paralysis

[…] of the upper motor neurons whereas infantile-onset spastic paralysis is more severe and involves degeneration of upper and lower motor neurons Symptoms - Hereditary spastic [checkorphan.org]

ALS2, JPLS and IAHSP are progressive disabling disorders that result from dysfunction of upper motor neurons (UMN) or affection of lower motor neurons (LMN). [deepdyve.com]

Because of loss of lower motor neurons, muscles undergo denervation atrophy. There is also degeneration of upper motor neurons. [neuropathology-web.org]

Spinal and Bulbar Muscular Atrophy

motor neuron degeneration. [ncbi.nlm.nih.gov]

Expansion of polyglutamine in the AR results in selective lower motor neuron degeneration and skeletal muscle atrophy. [ncbi.nlm.nih.gov]

Abstract X-linked spinal and bulbar muscular atrophy (SBMA) is characterized by adult-onset muscle weakness and lower motor neuron degeneration. [ncbi.nlm.nih.gov]

X-linked Spastic Paraplegia Type 16

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [cambridge.org]

motor neuron degeneration. [karger.com]

Autosomal Recessive Spastic Paraplegia Type 26

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [neurologyindia.com]

motor neuron degeneration. [omicsonline.org]

Amyotrophic Lateral Sclerosis Type 9

[…] in degenerating lower motor neurons. [orpha.net]

The pathological hallmarks comprise loss of motor neurons with intraneuronal ubiquitin-immunoreactive inclusions in upper motor neurons and TDP-43 immunoreactive inclusions [orpha.net]

Lower Motor Neuron Syndrome with Late-Adult Onset

In amyotrophic lateral sclerosis there is involvement of upper, lower, and brainstem motor neurons. [icd10data.com]

Progressive Muscular Atrophy (PMA) is marked by slow but progressive degeneration of only the lower motor neurons. [advancedpsy.com]

Autosomal Recessive Spastic Paraplegia Type 55

Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. [ghr.nlm.nih.gov]

Motor Neuron Disease

Slowly upper and lower motor neuron degeneration, even with non-motor clinical features, should prompt a sequencing of SOD1. [ncbi.nlm.nih.gov]

The patients also showed clinical and electrophysiological signs of upper and/or lower motor neuron degeneration. [ncbi.nlm.nih.gov]

Learn about this topic in these articles: major reference In muscle disease: Lower motor neuron disease Degeneration of the lower neuron produces a flaccid muscle weakness [britannica.com]