Lower Motor Neuron Disease: Causes & Reasons

Possible Causes for Lower Motor Neuron Disease

Other motor neuron diseases may affect only the upper motor neurons, only the lower motor neurons or a restricted selection of neurons. [memory.ucsf.edu]

If the upper motor neurons are not affected within two years, the disease usually remains a pure lower motor neuron disease. [my.clevelandclinic.org]

Clinicians typically use electromyography (EMG) to diagnose lower motor neuron disease. [memory.ucsf.edu]

Amyotrophic Lateral Sclerosis Type 2

neuron disease and little to no involvement of lower motor neurons. [symptoma.com]

If the upper motor neurons are not affected within two years, the disease usually remains a pure lower motor neuron disease. [my.clevelandclinic.org]

Besides those upper motor neuron signs, ALS patients usually show symptoms of lower motor neuron disease. [symptoma.com]

Amyotrophic Lateral Sclerosis Type 21

Amyotrophic lateral sclerosis, also known as motor neuron disease (MND), is a fatal neurodegenerative disease characterised by loss of upper and lower motor neurons in the [cochranelibrary.com]

Types of participants All those with a clinical diagnosis of ALS/MND (pure mixed upper motor neuron and lower motor neuron degeneration with supportive electromyogram) according [cochranelibrary.com]

[…] to the El Escorial criteria (Brooks 1994; Brooks 2000), at any stage of disease and with any clinical pattern of the condition (e.g. bulbar and limb onset). [cochranelibrary.com]

Progressive Muscular Atrophy

Progressive muscular atrophy (PMA), or the lower motor neuron disease, is a sporadic disorder characterized by onset in adulthood, pure lower motor neuron involvement and [ncbi.nlm.nih.gov]

The disease is related to ALS, where both the lower and upper motor neurons are involved. [umcutrecht.nl]

Progressive Muscular Atrophy (PMA) is a rarer and sometimes slower progressive form of Motor Neurone Disease affecting the lower motor neurones. What is PLS? [web.archive.org]

Upper Motor Neuron Disease

motor neuron disease? [journals.lww.com]

Upper Motor Neuron Disease vs. Lower Motor Neuron Disease We initiate movement through ideas formulated in the brain. [newhealthadvisor.com]

Scleroses, LOWER MOTOR NEURON DIS, SECOND MOTOR NEURON DIS, Motor Neuron Disease, Lower, motor neuron disease or disorder, Motor System Diseases, motor neuron disease, Motor [ebi.ac.uk]

Distal Spinal Muscular Atrophy Type 4

OBJECTIVE: To describe the clinical features of a novel variant of autosomal recessive lower motor neuron disease (LMND) with childhood onset and to map the disease-causing [ncbi.nlm.nih.gov]

Conclusion: Genetic mapping of a novel rare phenotype of lower motor neuron disease opens the way toward the identification of a new gene involved in motor neuron degeneration [neurology.org]

CONCLUSION: Genetic mapping of a novel rare phenotype of lower motor neuron disease opens the way toward the identification of a new gene involved in motor neuron degeneration [ncbi.nlm.nih.gov]

Motor Neuron Disease

Learn about this topic in these articles: major reference In muscle disease: Lower motor neuron disease Degeneration of the lower neuron produces a flaccid muscle weakness [britannica.com]

This study shows that SOD1 G93D mutation causes a slowly developing lower motor neuron disease with a reduced penetrance. [ncbi.nlm.nih.gov]

Upper Motor Neuron Disease vs. Lower Motor Neuron Disease We initiate movement through ideas formulated in the brain. [newhealthadvisor.com]

Spinal and Bulbar Muscular Atrophy

The fundamental histopathological finding of this disease is an extensive loss of lower motor neurons in the spinal cord and brainstem. [ncbi.nlm.nih.gov]

The X-linked spinal and bulbar muscular atrophy (Kennedy's disease) is a rare X-linked, recessive, lower motor neuron disease, characterized by weakness, atrophy, and fasciculations [ncbi.nlm.nih.gov]

Abstract Spinal and bulbar muscular atrophy (SBMA), or Kennedy disease, is an adult-onset lower motor neuron disease characterized by slowly progressive muscle weakness and [ncbi.nlm.nih.gov]

Primary Lateral Sclerosis

neuron (UMN) features in at least 2 body regions on examination EMG within 3 months of enrollment with minimal or no evidence of lower motor neuron disease Time from symptom [ufhealth.org]

If the upper motor neurons are unaffected within two years, the disease usually remains a pure lower motor neuron disease. [hopkinsmedicine.org]

neuron dysfunction Disease is progressive, but may persist for decades Evidence of loss of function in the lower extremities (LEs) first, then progressing to the muscles [accessphysiotherapy.mhmedical.com]

Progressive Bulbar Paralysis

You could try the homeopathic drug ‘Gelsemium’ which has profound benefit on patients with other forms of lower motor neuron disease. [tandurust.com]

If the upper motor neurons are unaffected within two years, the disease usually remains a pure lower motor neuron disease. [hopkinsmedicine.org]

Background/Aims: Degenerative lower motor neuron diseases (LMND) encompass a group of rare clinically and genetically heterogeneous disorders with the hallmark of anterior [scinapse.io]

Distal Spinal Muscular Atrophy Type 5

Interestingly, this mutation causing a loss-of-function of HSJ1 is linked to a pure lower motor neuron disease, strongly suggesting that HSJ1 also plays an important and specific [ncbi.nlm.nih.gov]

ENS Review 417 Downloads 18 Citations Abstract The term motor neurone disease encompasses combined upper and lower motor neurone disorders (amyotrophic lateral sclerosis), [link.springer.com]

Lower motor neuron syndrome (LMNS) arises from a disease process affecting the spinal motor neuron itself. [em-consulte.com]

Lower Motor Neuron Syndrome with Late-Adult Onset

The disease forms in both families in our opinion further broaden the spectrum of motor neuron disease Key words Lower motor neuron disease Hereditary Spinal muscular atrophy [link.springer.com]

Abstract The discovery of the genetic basis of hereditary lower motor neuron disease (LMND) and the recognition of multifocal motor neuropathy as a distinct clinical entity [ncbi.nlm.nih.gov]

Motor Neuron Disease 77 terms Rx: Headache 25 terms Neuro Common Neurologic Deficits [quizlet.com]

Distal Spinal Muscular Atrophy

disease dynactin type PLMND Progressive lower motor neuron disease Keywords Any medical or genetic information present in this entry is provided for research, educational [uniprot.org]

Conclusion : A homozygous HSJ1 chaperone mutation is related to a rare lower motor neuron disease, characterized by distal hereditary motor neuropathy and was described in [deepdyve.com]

Pseudobulbar Palsy

[…] expression.[5] See also[edit] Corticobulbar tract Bulbar palsy, a similar syndrome caused by the damage of lower motor neurons. [en.wikipedia.org]

Motor neuron disease References[edit] ^ Tidy C (21 October 2021). Knott L (ed.). "Bulbar and Pseudobulbar Palsy. What is Bulbar Palsy?". Patient. [en.wikipedia.org]

[…] brainstem and cerebellum, which are hypothesized to be involved in pseudobulbar symptoms, and acts as a sigma ligand, binding to the sigma-1 receptors that mediate the emotional motor [en.wikipedia.org]

Amyotrophic Lateral Sclerosis Type 1

If the upper motor neurons are unaffected within two years, the disease usually remains a pure lower motor neuron disease. [hopkinsmedicine.org]

Motor neuron disease variant with only lower or upper motor neuron signs Primary lateral sclerosis (upper motor neuron only) ? [neuromuscular.wustl.edu]

Definition A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. [uniprot.org]

Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis is the most common neurodegenerative upper and lower motor neuron disease in adults but is not common in women of child-bearing age. [ncbi.nlm.nih.gov]

If the upper motor neurons are not affected within two years, the disease usually remains a pure lower motor neuron disease. [my.clevelandclinic.org]

If the upper motor neurons are unaffected within two years, the disease usually remains a pure lower motor neuron disease. [hopkinsmedicine.org]

Amyotrophic Lateral Sclerosis Type 6

If the upper motor neurons are not affected within two years, the disease usually remains a pure lower motor neuron disease. [my.clevelandclinic.org]

ALS diagnosis relies on the identification of upper motor neuron and lower motor neuron signs, to be observed in patients suffering from a progressive neurodegenerative disease [symptoma.com]

If the lower motor neurons are not affected within two years, the disease usually remains a pure upper motor neuron disease. This is the rarest of all forms of ALS. [my.clevelandclinic.org]

X-linked Distal Spinal Muscular Atrophy Type 3

Type VIIA HMN7A 158580 Genetic Test Registry Neuronopathy, Distal Hereditary Motor, Type VIIB Lower Motor Neuron Disease, Dynactin Type Neuropathy, Distal Hereditary Motor [ukgtn.nhs.uk]

Clinical science Summary Spinal muscular atrophy (SMA) refers to a group of autosomal recessive motor neuron diseases that are caused by apoptosis of lower motor neurons. [amboss.com]

[…] later to other muscles Kennedy’s disease (KD)— Unlike spinal muscular atrophy, which affects the motor neurons, KD affects both lower motor and sensory neurons and only occurs [togetherinsma.com]

Adult Spinal Muscular Atrophy

The examination may show all the characteristic findings of a lower motor neuron disease, namely absent/decreased reflexes, hypotonia, flaccid paralysis and muscle fasciculations [symptoma.com]

Electrophysiological studies showed patterns of lower motor neuron disease and genetic test showed P56S mutation of VAPB gene. [neurology.org]

[…] both the upper and lower motor neurones. [daneverard.co.uk]

Amyotrophic Lateral Sclerosis Type 5

If the upper motor neurons are not affected within two years, the disease usually remains a pure lower motor neuron disease. [my.clevelandclinic.org]

If the upper motor neurons are unaffected within two years, the disease usually remains a pure lower motor neuron disease. [hopkinsmedicine.org]

Lou Gehrig disease; ALS; Upper and lower motor neuron disease; Motor neuron disease Fearon C, Murray B, Mitsumoto H. Disorders of upper and lower motor neurons. [medlineplus.gov]

Amyotrophic Lateral Sclerosis Type 9

If the upper motor neurons are unaffected within two years, the disease usually remains a pure lower motor neuron disease. [hopkinsmedicine.org]

If the lower motor neurons are not affected within two years, the disease usually remains a pure upper motor neuron disease. This is the rarest form of ALS. [hopkinsmedicine.org]

Amyotrophic Lateral Sclerosis Type 11

Signs of upper motor neuron and lower motor neuron damage not explained by any other disease process are suggestive of ALS. [orpha.net]

Besides those lower motor neuron signs, ALS patients may show distinct symptoms of upper motor neuron disease. [symptoma.com]

[…] in degenerating lower motor neurons. [orpha.net]

Distal Spinal Muscular Atrophy Type 3

Type VIIA HMN7A 158580 Genetic Test Registry Neuronopathy, Distal Hereditary Motor, Type VIIB Lower Motor Neuron Disease, Dynactin Type Neuropathy, Distal Hereditary Motor [ukgtn.nhs.uk]

There are forms of motor neuron disease that affect selectively either upper motor neurons ( pure upper motor neuron syndrome/primary lateral sclerosis) or lower motor neurons [explainmedicine.com]

Clinical science Summary Spinal muscular atrophy (SMA) refers to a group of autosomal recessive motor neuron diseases that are caused by apoptosis of lower motor neurons. [amboss.com]

Granulomatous Myositis

motor neuron disease. ( 18700190 ) Gdynia H.J....Sperfeld A.D. 2008 16 Paediatric contracturing granulomatous myositis. ( 18821276 ) Bowers B....Seidman R.J. 2008 17 Granulomatous [malacards.org]

Pattern of weakness and other signs In addition to diseases of muscle, weakness can be caused by disorders of upper motor neurons, lower motor neurons, and the neuromuscular [rheumatologyadvisor.com]

[…] muscle involvement in granulomatous myositis can mimic inclusion body myositis. ( 20562458 ) Larue S....Dubourg O. 2011 15 Granulomatous myositis mimicking slowly progressive lower [malacards.org]

Amyotrophic Lateral Sclerosis Type 10

If the upper motor neurons are not affected within two years, the disease usually remains a pure lower motor neuron disease. [my.clevelandclinic.org]

If the upper motor neurons are unaffected within two years, the disease usually remains a pure lower motor neuron disease. [hopkinsmedicine.org]

Amyotrophic Lateral Sclerosis Type 3

If the upper motor neurons are not affected within two years, the disease usually remains a pure lower motor neuron disease. [my.clevelandclinic.org]

If the upper motor neurons are unaffected within two years, the disease usually remains a pure lower motor neuron disease. [hopkinsmedicine.org]

Besides those lower motor neuron signs, ALS patients may show distinct symptoms of upper motor neuron disease. [symptoma.com]

Amyotrophic Lateral Sclerosis Type 8

If the upper motor neurons are not affected within two years, the disease usually remains a pure lower motor neuron disease. [my.clevelandclinic.org]

Distal Hereditary Motor Neuropathy Type 1

Type VIIB Lower Motor Neuron Disease, Dynactin Type Neuropathy, Distal Hereditary Motor, Type VIIB Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type VIIB [ukgtn.nhs.uk]

motor neuron disease with childhood onset. [genome.jp]

Distal, Type V Spinal Muscular Atrophy, Distal, With Upper Limb Predominance HMN5 DHMN V DHMN5 DSMAV HMN V 600794 Genetic Test Registry Neuronopathy, Distal Hereditary Motor [ukgtn.nhs.uk]

Scapuloperoneal Spinal Muscular Atrophy

Abstract Objective: Characterization of a new type of late-onset autosomal dominant lower motor neuron disease. [n.neurology.org]

Type VIIA HMN7A 158580 Genetic Test Registry Neuronopathy, Distal Hereditary Motor, Type VIIB Lower Motor Neuron Disease, Dynactin Type Neuropathy, Distal Hereditary Motor [ukgtn.nhs.uk]

Lower motor and primary sensory neuron diseases with peroneal muscular atrophy. Arch. Neurol. (Chic.) 18, 603 (1968). Google Scholar Emery, E. S., Fenichel, G. [link.springer.com]

Juvenile Primary Lateral Sclerosis

Home Motor Neuron Disease Motor Neuron Disease, Primary Lateral Sclerosis, Lateral Sclerosis, Upper Motor Neuron Disease, Lower Motor Neuron Disease, Motor System Disease, [xpertdox.com]

The guys in the brain are called the upper motor neurons, and the guys in the spine are called the lower motor neurons. [scientificamerican.com]

These should be distinguished from diseases in which primarily the axons of motor neurons are affected. [emedicine.medscape.com]