Lupus Anticoagulant: Causes & Reasons

Possible Causes for Lupus Anticoagulant

Risk factors are usually divided into acquired (e.g. surgery, trauma, pregnancy, puerperium, lupus anticoagulant, malignant disease, and female hormones) and genetic (congenital [karger.com]

anticoagulant, or factor V Leiden mutation Cancer Collagen vascular diseases like lupus, Wegener’s granulomatosis, and Behcet syndrome Obesity Low blood pressure in the brain [hopkinsmedicine.org]

Pregnancy and the first few weeks after delivery Problems with blood clotting; for example, antiphospholipid syndrome, protein C and S deficiency, antithrombin III deficiency, lupus [hopkinsmedicine.org]

Phlegmasia Cerulea Dolens

[…] and antiphospholipid antibodies identified by a positive lupus anticoagulant assay. [ncbi.nlm.nih.gov]

We show that phlegmasia may occur in a previously healthy man with positive lupus anticoagulant. [ncbi.nlm.nih.gov]

We present a unique case of a patient with PCD refractory to anticoagulant and thrombolytic therapy, whose fulminant course was attributed to concurrent cholangiocarcinoma [ncbi.nlm.nih.gov]

Lupus Erythematosus

double stranded DNA FDA : Food and Drug Administration LA : systemic lupus erythematosus anticoagulant LAC : lupus anticoagulant MMF : mycophenolate mofetil NLE : neonatal [pedsinreview.aappublications.org]

Dauzenberg Lupus anticoagulant and thrombosis in systemic lupus erythematosus [16.] M.L. Boey, C.B. Colaco, A.E. Gheravi, K.B. Elkon, S. Loizou, G.R.V. [archbronconeumol.org]

anticoagulant … View Full Text Log in using your username and password Log in through your institution You may be able to gain access using your login credentials for your [pedsinreview.aappublications.org]

Systemic Lupus Erythematosus with Organ/System Involvement

The lupus anticoagulant was present in the patient with chorea and was frequently present in patients with cerebral vascular events. [ncbi.nlm.nih.gov]

We defined aPL as the presence of a lupus anticoagulant (LAC), immunoglobulin G or immunoglobulin M anticardiolipin antibodies (aCLs), or a biologic false-positive serologic [ncbi.nlm.nih.gov]

Superior Mesenteric Vein Thrombosis

Positive tests for lupus anticoagulant in the initial period may be unreliable due to heparin treatment. [ncbi.nlm.nih.gov]

Lupus anticoagulant antibody was positive. He was initiated on heparin and then transitioned to warfarin. [omicsonline.org]

anticoagulant utilizing fluoroscopically guided percutaneous mesocaval shunt creation. [ncbi.nlm.nih.gov]

Libman-Sacks Disease

On rheumatologic work-up, she was found to have positive anticardiolipin IgG and lupus anticoagulant. [cardiovascimaging.portal.tools]

Hematological workup showed an isolated lupus anticoagulant with normal anti-cardiolipin antibodies. Repeat lupus anticoagulant a few days later was negative. [ncbi.nlm.nih.gov]

In the second rheumatologic biochemistry workup, lupus anticoagulant was also found to be positive. [cardiovascimaging.portal.tools]

Lupus Encephalitis

lupus anticoagulant syndrome? sm Subject: lupus anticoagulant syndrome? [mtstars.com]

Diagnosis Advances in Lupus Treatment Cerebral and CNS Lupus Chilblain Lupus Discoid Lupus Discoid Lupus Erythmatosus Lupus Anticoagulant Lupus Case Reports Lupus Cerebritis [omicsonline.org]

The patient is positive for IgM anticardiolipin antibody and lupus anticoagulant, where pediatric rheumatology and hematology confirmed diagnosis of cerebral venous sinus [glosbe.com]

Systemic Lupus Erythematosus

Abstract Lupus anticoagulant, also known as lupus antibody, is generally associated with thrombosis rather than bleeding events. [ncbi.nlm.nih.gov]

We report two children with systemic lupus erythematosus (SLE) having severe bleeding manifestations and lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) along with [ncbi.nlm.nih.gov]

Chorea Gravidarum

Read More Download full-text PDF Source Lupus anticoagulant in pregnancy. [pubfacts.com]

anticoagulant: successful outcome of pregnancy with prednisone and aspirin therapy. [malacards.org]

Lupus anticoagulant test. Liver function test. Electrolyte panel. Slit lamp examination. [epainassist.com]

Intracranial Sinus Thrombosis

Risk factors are usually divided into acquired (e.g. surgery, trauma, pregnancy, puerperium, lupus anticoagulant, malignant disease, and female hormones) and genetic (congenital [karger.com]

The hypercoagulable workup was negative for a lupus anticoagulant, anticardiolipin antibodies and beta-2 glycoprotein-I antibodies on two separate occasions in September and [path.upmc.edu]

anticoagulant, or factor V Leiden mutation Cancer Collagen vascular diseases such as lupus, granulomatosis with polyangiitis, and Behcet syndrome Obesity Low blood pressure [elcaminohospital.org]

Acquired Coagulation Factor Deficiency

Chapter First Online: 28 July 2016 Abstract Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is an uncommon disorder, characterized by a positive lupus anticoagulant [link.springer.com]

Transient lupus anticoagulants associated with hemorrhage rather than thrombosis: the hemorrhagic lupus anticoagulant syndrome. [emj.bmj.com]

It is most frequently diagnosed in the presence of lupus anticoagulants, then constituting the so-called lupus anticoagulant-hypoprothrombinemia syndrome (LAHS). [symptoma.com]

Habitual Abortion

Lupus anticoagulants (LA) are associated with various forms of thrombotic events. [ncbi.nlm.nih.gov]

We conclude that, in the majority of women, subclinical lupus, anti-Ro, the lupus anticoagulant, and anticardiolipin antibodies are not associated with idiopathic habitual [ncbi.nlm.nih.gov]

Miscarriage is sometimes associated with substances in the mother blood called 'antiphospholipid antibodies' or 'lupus anticoagulant'. [doi.org]

Recurrent Thrombophlebitis due to Hereditary Disorders

Later studies found a protein called the lupus anticoagulant in a number of individuals with SLE. [genome.gov]

anticoagulant, 13) Antiphospholipid antibodies)*can be on both lists Smoking [quizlet.com]

These lupus anticoagulant and anticardiolipin antibodies are on most lupus panels. [vascularcenterwf.com]

Hereditary Coagulopathy

[…] antibodies: APTT PT Mixing studies PT mixing studies Incubated aPTT mixing studies Lupus anticoagulant screening Lupus confirmation Anti-cardiolipen Antibodies Anti-B2 GP1 [dmcul.org]

Conversely, patients with recurrent thromboembolic events should be anticoagulated even if their workup uncovers no evidence of an underlying thrombophilia or a lupus anticoagulant [emedicine.medscape.com]

anticoagulant using a standard method, or (3) a false-positive... ‎ [books.google.de]

Sneddon's Syndrome

Patient 1 had anticardiolipin antibody and patient 2 had lupus anticoagulant, which we detected only upon repeated blood testing. [ncbi.nlm.nih.gov]

Our results support a temporal relation between thrombotic events in Sneddon's syndrome and lupus anticoagulant; anticardiolipin antibodies remained invariable. [ncbi.nlm.nih.gov]

Hemostasis was normal except for a mild increase of fibrinogen in one subject; lupus anticoagulant (LAC) and anticardiolipin antibodies were negative in all. [ncbi.nlm.nih.gov]

Anticardiolipin Antibody Syndrome

The lupus anticoagulant and anticardiolipin antibody may occur in these patients, and both may cause arterial and venous thromboses. [health.am]

Figure 1: ISTH SSC criteria for Lupus Anticoagulant. [omicsonline.org]

Most often, lupus anticoagulants and aPL are found in people with diseases such as systemic lupus erythematosus (SLE). [medlineplus.gov]

Factor II Deficiency

The main clinical sequela of a lupus anticoagulant is increased thrombosis risk. [ncbi.nlm.nih.gov]

The lupus anticoagulant is a well-described in vitro phenomenon that may be associated with arterial and venous thrombotic episodes. [ncbi.nlm.nih.gov]

The disparate response of the lupus anticoagulant and hypoprothrombinemia to immunosuppression suggests that the lupus anticoagulant did not directly cause the hypoprothrombinemia [ncbi.nlm.nih.gov]

Acquired Hemophilia

A prolonged aPTT can be due to coagulation factor deficiencies, lupus anticoagulant (LAC) or heparin therapy. [medcraveonline.com]

[…] desmopressin, azathioprine AHA, acquired hemophilia A; APTT, activated partial thromboplastin time; CPA, cyclophosphamide; aPCC, activated prothrombin complex concentrate; LAC, lupus [medcraveonline.com]

Interference can result from anticoagulants or lupus anticoagulant. [ncbi.nlm.nih.gov]

Idiopathic Recurrent and Disabling Cutaneous Herpes

Serologic markers for antiphospholipid syndrome are antiphospholipid antibodies (beta2-GPI or anticardiolipins) or lupus anticoagulant. [emedicine.medscape.com]

Some authors suggest using low-dose aspirin in patients with persistent lupus anticoagulant or high levels of IgG anticardiolipin. [emedicine.medscape.com]

In a large retrospective study from the Mayo Clinic, 41% of patients with lupus anticoagulant had skin lesions as the first sign of antiphospholipid syndrome. [5] Cutaneous [emedicine.medscape.com]

Hereditary Protein C Deficiency

anticoagulant, lupus anticoagulant disorder, postpartum (after childbirth) antiphospholipid syndrome, postpartum antiphospholipid syndrome, protein C deficiency disease, [healthresearchfunding.org]

anticoagulant). [mymemory.translated.net]

anticoagulant Lupus anticoagulant disorder Postpartum (after childbirth) antiphospholipid syndrome Postpartum antiphospholipid syndrome Protein C deficiency disease Protein [icd9data.com]

Thrombophilia due to Activated-Protein C Resistance

anticoagulant Lupus anticoagulant disorder Postpartum (after childbirth) antiphospholipid syndrome Postpartum antiphospholipid syndrome Protein C deficiency disease Protein [icd9data.com]

anticoagulant with hypercoagulable state Protein C deficiency Protein S deficiency Prothrombin gene mutation Systemic lupus erythematosus [SLE] inhibitor with hypercoagulable [icd9data.com]

Antiphospholipid Syndrome

Abstract Lupus anticoagulant-hypoprothrombinemia syndrome is a rare condition characterized by the association of acquired factor II deficiency and lupus anticoagulant. [ncbi.nlm.nih.gov]

Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. [dx.doi.org]

We report a patient, positive for antidomain I antibodies, with initially primary lupus anticoagulant-hypoprothrombinemia syndrome without previous clinical manifestation [ncbi.nlm.nih.gov]

Acquired Hemophilia A

INTRODUCTION: Lupus anticoagulant (LA) is an antibody that interferes with in vitro coagulation reactions. [ncbi.nlm.nih.gov]

Other causes of isolated prolonged aPTT such as a lupus anticoagulant must also be considered. [ncbi.nlm.nih.gov]

Lupus Anticoagulant APTT is prolonged in the presence of lupus anticoagulants that interfere with the assembly and activity of the FXa-FVa-Ca2+ phospholipid complex. [hindawi.com]

Gingival Hematoma

Conclusion: The haemorrhagic lupus anticoagulant syndrome (acquired hypoprothrombinaemia lupus anticoagulant syndrome) is a rare presentation of acquired bleeding diathesis [pubmed.ncbi.nlm.nih.gov]

[…] syndrome (acquired hypoprothrombinaemia lupus anticoagulant syndrome) is a rare presentation of acquired bleeding diathesis in childhood. [ncbi.nlm.nih.gov]

Bleeding in patients with lupus anticoagulant. Lancet 1984;2(8407):868-9. 8. Peacock NW, Levine SP. Case report: the lupus anticoagulant hypoprothrombinaemia syndrome. [sjkdt.org]

Cerebral Venous Sinus Disorder

anticoagulant, or factor V Leiden mutation Cancer Collagen vascular diseases like lupus, granulomatosis with polyangiitis, and Behcet syndrome Obesity Low blood pressure [hopkinsmedicine.org]

anticoagulant, or factor V Leiden mutation Cancer Collagen vascular diseases such as lupus, granulomatosis with polyangiitis, and Behcet syndrome Obesity Low blood pressure [cedars-sinai.edu]

Hypercoagulable states associated with the antiphospholipid syndrome and thrombophilia, including protein S and C deficiencies, antithrombin III deficiency, lupus anticoagulant [patient.info]

Livedo Reticularis

Biological tests are required, including testing for lupus anticoagulant activity. [medicaljournals.se]

The lupus anticoagulant panel should be ordered in acquired livedo that is not induced by the cold. [dermnetnz.org]

The antiphospholipid antibody (APS) syndrome is characterized by antiphospholipid antibodies (lupus anticoagulant [LA] or anticardiolipin [aCL], a recurrent arterial and venous [ncbi.nlm.nih.gov]

Factor XII Deficiency

Guidelines for testing and revised criteria for lupus anticoagulants. SSC Subcommittee for the standardization of lupus anticoagulants. [doi.org]

Yet, lupus anticoagulant and antibodies to β-2-glycoprotein I were absent (table 1 and 2 ). [translational-medicine.biomedcentral.com]

anticoagulant or anticardiolipin antibody syndrome should also be investigated for deficiencies of factors VIII, IX, and XII. [ncbi.nlm.nih.gov]

Venous Thrombosis

Abstract The lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) - the association of acquired factor II deficiency and lupus anticoagulant - is a rare disease that [ncbi.nlm.nih.gov]

Thrombosis in patients with the lupus anticoagulant. [ncbi.nlm.nih.gov]

Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. [dx.doi.org]

Protein S Deficiency

anticoagulant Lupus anticoagulant disorder Postpartum (after childbirth) antiphospholipid syndrome Postpartum antiphospholipid syndrome Protein C deficiency disease Protein [icd9data.com]

anticoagulant ( D68.62 ) secondary activated protein C resistance ( D68.69 ) secondary antiphospholipid antibody syndrome ( D68.69 ) secondary lupus anticoagulant with hypercoagulable [icd10data.com]

We assayed for free protein S antigen, protein C antigen, and antithrombin III and tested for lupus-like anticoagulant and anticardiolipin antibody. [n.neurology.org]

Malignant Atrophic Papulosis

Laboratory investigations revealed a mutation of factor V Leiden and the presence of lupus anticoagulant, but no anti-cardiolipin antibodies. [ncbi.nlm.nih.gov]

We found presence of lupus anticoagulant in our patient. [medicaljournals.se]

A search for anti-nuclear antibodies, lupus anticoagulant, and anticardiolipin antibodies should be performed in each patient. [dermaamin.com]