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534 Possible Causes for Lupus Nephritis, Thrombocytopenia

  • Systemic Lupus Erythematosus

    Blood platelet counts (BPCs) of 20   10/L represent severe thrombocytopenia, and a BPC of 21 to 50   10/L indicates moderate thrombocytopenia.[ncbi.nlm.nih.gov] What is lupus nephritis? There are two types of lupus.[kidney.org] Work-up suggested a diagnosis of active SLE with anaemia, thrombocytopenia, positive antinuclear antibodies (ANAs) and positive anti-double-stranded DNA.[ncbi.nlm.nih.gov]

  • Thrombotic Thrombocytopenic Purpura

    Careful analysis revealed the development of heparin-induced thrombocytopenia (HIT) that precluded platelet count (PLT) normalization.[ncbi.nlm.nih.gov] Autoimmune disease (lupus nephritis, acute scleroderma). Vasculitis. Haemolytic uraemic syndrome (diarrhoea positive/negative). Malignancy.[patient.info] Thrombotic thrombocytopenia purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by thrombocytopenia and microangiopathic hemolytic anemia[ncbi.nlm.nih.gov]

  • Nephrotic Syndrome

    We herein describe a case of nephrotic syndrome with thrombocytopenia, lymphadenopathy, systemic inflammation, splenomegaly, kidney enlargement, and progressive renal insufficiency[ncbi.nlm.nih.gov] Nephrotic syndrome (NS) is a major manifestation of lupus nephritis (LN).[ncbi.nlm.nih.gov] However, in thesetting of a nephrotic child who develops gross hematuria, thrombocytopenia, or unexplained persistent hypertension, renal ultrasound should be considered to[slideplayer.com]

  • Chronic Myelomonocytic Leukemia

    thrombocytopenia").[ncbi.nlm.nih.gov] Most common causes include allergic reactions (eg, drug-induced), infections, auto-immune and infiltrative processes (eg, lupus nephritis and sarcoidosis), inflammatory disease[dovepress.com] Thrombocytopenia is usually the result of megakaryocytic dysplasia but the number of megakaryocytes may also be low contributing to thrombocytopenia.[pathpedia.com]

  • Immunosuppressive Drug

    Review Topic QID: 101013 1 Nephrotoxicity, hypertension 3 Hyperlipidemia, thrombocytopenia 4 Cytokine release syndrome, hypersensitivity reaction 5 Nephrotoxicity, gingival[medbullets.com] lupus nephritis,” lead author Candace Feldman, MD, MPH, assistant professor of medicine, Harvard Medical School in Boston, and associate physician at Brigham and Women’s[the-rheumatologist.org] […] cumulative manifestations of SLE, in decreasing order of frequency, were musculoskeletal (70.3%), renal (52%), facial rash (46%), leukopenia (36%), photosensitivity (26%), thrombocytopenia[acrabstracts.org]

  • Cladribine

    Hematologic toxicity was frequent: grade 3 anemia in 12%, grade 3 thrombocytopenia in 41%, grade 4 thrombocytopenia in 24%, grade 3 neutropenia in 6%, and grade 4 neutropenia[ncbi.nlm.nih.gov] Renal biopsy revealed WHO Class III lupus nephritis.[ard.bmj.com] Adverse Reactions: Severe myelosuppression (eg, neutropenia, anemia, thrombocytopenia), fever, infection, fatigue, nausea, rash, headache, inj site reactions, others; neurotoxicity[cancertherapyadvisor.com]

  • Lupus Erythematosus

    Blood platelet counts (BPCs) of 20   10/L represent severe thrombocytopenia, and a BPC of 21 to 50   10/L indicates moderate thrombocytopenia.[ncbi.nlm.nih.gov] The results suggest that lupus nephritis might be associated with physical activity.[ncbi.nlm.nih.gov] Yet, their roles in systemic lupus erythematosus (SLE) and lupus nephritis (LN) remain to be elucidated.[ncbi.nlm.nih.gov]

  • Azathioprine

    The resulting blood dyscrasias, leucopenia, thrombocytopenia or pancytopenia, can be life threatening.[medsafe.govt.nz] […] maintenance therapy in a Caucasian population suffering from proliferative lupus nephritis.[ard.bmj.com] Decreased red blood cell count (anemia) Other Serious Side Effects Liver toxicity Decreased platelet count (thrombocytopenia) Increased risk of infections Cancer Drug Interactions[unckidneycenter.org]

  • Noonan Syndrome 1

    Thrombocytopenia and abnormal platelet function with abnormalities of coagulation factors are found in about 50% of cases resulting in easy bruising and prolonged bleeding[disorders.eyes.arizona.edu] […] most common and most severe form of lupus nephritis.[omicsonline.org] Due to coagulation factor deficiencies, platelet dysfunction, and/or thrombocytopenia, affected individuals may have a history of abnormal and easy bruising and bleeding.[rarediseases.org]

  • Tacrolimus

    Both patients (cases 1 and 2) developed fever, anasarca, thrombocytopenia, renal dysfunction, and mild hepatosplenomegaly.[ncbi.nlm.nih.gov] To further explore this, Mok and colleagues enrolled 150 patients between 2005 and 2012, all of whom had active lupus nephritis.[medpagetoday.com] Hematologic: anemia, leukocytosis, THROMBOCYTOPENIA. Musculoskeletal: back pain. Respiratory: pleural effusion, atelectasis, dyspnea. Skin: pruritus, rash.[glowm.com]

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