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569 Possible Causes for Lupus Nephritis, Thrombocytopenia

  • Systemic Lupus Erythematosus

    Blood platelet counts (BPCs) of 20   10/L represent severe thrombocytopenia, and a BPC of 21 to 50   10/L indicates moderate thrombocytopenia.[] What is lupus nephritis? There are two types of lupus.[] A 40-year-old woman with systemic lupus erythematosus (SLE) presented with high-grade fever and severe thrombocytopenia.[]

  • Atypical Hemolytic Uremic Syndrome

    A 28-day-old female presented with gross hematuria and hypertension. aHUS was suspected based on anemia with schistocytes, thrombocytopenia, low C3, and acute kidney injury[] She was diagnosed with systemic lupus erythematosus (SLE) and class V lupus nephritis.[] Investigations revealed hemolytic anemia, thrombocytopenia, renal impairment, and a low serum C3, leading to the diagnosis of aHUS.[]

  • Gaucher Disease

    Medical examination showed slight splenomegaly (250 62 mm), thrombocytopenia (platelets 51 109/L), anemia (Hb levels 107 g/L), and β-glucocerebrosidase activity (GBA) in leukocytes[] We reported the immunological evaluation of a patient with GD and lupus nephritis.[] Gaucher disease is a common inborn error of metabolism leading to widespread chronic inflammation and often thrombocytopenia.[]

  • Thrombotic Thrombocytopenic Purpura

    Unfortunately, there is no clear guidance for when thrombocytopenia is refractory for a prolonged period of time.[] The definitive diagnosis was lupus nephritis with TTP.[] Careful analysis revealed the development of heparin-induced thrombocytopenia (HIT) that precluded platelet count (PLT) normalization.[]

  • Nephrotic Syndrome

    We herein describe a case of nephrotic syndrome with thrombocytopenia, lymphadenopathy, systemic inflammation, splenomegaly, kidney enlargement, and progressive renal insufficiency[] Renal histology showed International Society of Nephrology/Renal Pathology Society Class II lupus nephritis.[] Thrombocytopenia finally led to uncontrollable gastrointestinal bleeding as the direct cause of the patient's death.[]

  • Chronic Myelomonocytic Leukemia

    The aim of our study was to analyze the association of immune thrombocytopenia (ITP) with chronic myelomonocytic leukemia (CMML).[] Most common causes include allergic reactions (eg, drug-induced), infections, auto-immune and infiltrative processes (eg, lupus nephritis and sarcoidosis), inflammatory disease[] thrombocytopenia").[]

  • Eclampsia

    Thrombocytopenia-absent radius (TAR) syndrome affects 0.5-1/100,000 live births.[] A woman with lupus nephritis presented 7 days postpartum with eclampsia. Postseizure findings included dramatic short-term memory loss.[] Hypertension plus other signs such as thrombocytopenia, elevated serum transaminase levels, or systemic organ failure is also sufficient for the diagnosis of preeclampsia[]

  • Cladribine

    Hematologic toxicity was frequent: grade 3 anemia in 12%, grade 3 thrombocytopenia in 41%, grade 4 thrombocytopenia in 24%, grade 3 neutropenia in 6%, and grade 4 neutropenia[] Renal biopsy revealed WHO Class III lupus nephritis.[] We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.[]

  • Azathioprine

    Subgroups with leukopenia, anemia, thrombocytopenia, and liver dysfunction did not differ in concentrations of 6-TG or 6-MMP.[] To compare the efficacy of mycophenolate mofetil (MMF) with that of azathioprine (AZA) drugs in the maintenance therapy of lupus nephritis (LN) patients, we studied 81 Sudanese[] The resulting blood dyscrasias, leucopenia, thrombocytopenia or pancytopenia, can be life threatening.[]

  • Noonan Syndrome 1

    Thrombocytopenia and abnormal platelet function with abnormalities of coagulation factors are found in about 50% of cases resulting in easy bruising and prolonged bleeding[] […] most common and most severe form of lupus nephritis.[] Due to coagulation factor deficiencies, platelet dysfunction, and/or thrombocytopenia, affected individuals may have a history of abnormal and easy bruising and bleeding.[]

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