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12 Possible Causes for Luteinizing Hormone Low, Male Infertility due to Globozoospermia, Obesity

  • Klinefelter Syndrome

    Obesity is reported to have adverse effects on semen quality and the endocrine system.[ncbi.nlm.nih.gov] Endocrinological examination revealed a high growth hormone (GH) concentration, low testosterone concentration, and high follicle-stimulating hormone and luteinizing hormone[ncbi.nlm.nih.gov] The patient was a 21-year-old, tall and obese man. He had gynecomastia. The penis was short and bilateral testes were underdeveloped.[doi.org]

  • Kallmann Syndrome

    Patients with this genetic form of KS have been reported to have a possible increased prevalence of obesity and sleep disorders, which may be related to the role of PROK2[ncbi.nlm.nih.gov] Serum luteinizing hormone levels were low or normal.[popline.org] A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998 Mar 26. 392(6674):398-401. [Medline].[emedicine.medscape.com]

  • Cushing's Disease

    It usually manifests as endocrinological deficits such as short stature, delayed puberty, and obesity.[ncbi.nlm.nih.gov] The symptoms depend upon which hormone is involved. Reduction of sex hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH).[pituitary.ucla.edu] In this paper, we report the case of a 10-year-old male patient with hypophyseal microadenoma-related Cushing's disease who presented with obesity and was found to show poor[ncbi.nlm.nih.gov]

  • Acromegaly

    High AG/UAG ratios are linked with type 2 diabetes, obesity, and hyperphagia (e.g., in Prader-Willi syndrome).[ncbi.nlm.nih.gov] Endocrinological examination revealed a high growth hormone (GH) concentration, low testosterone concentration, and high follicle-stimulating hormone and luteinizing hormone[ncbi.nlm.nih.gov] Most of the acromegaly-related comorbidities identified here are known to increase with age and obesity.[ncbi.nlm.nih.gov]

  • Male Infertility due to Globozoospermia

    Salgado's group studied the medical records of 12 obese men who sought treatment for infertility and received a diagnosis of obesity-related hypogonadotropic hypogonadism.[eurekalert.org] If the testosterone level is low, a repeat measurement of total and free testosterone (or bioavailable testosterone), as well as determination of serum luteinizing hormone[auanet.org] CONCLUSION(S): ICSI is an effective treatment in couples that failed to conceive spontaneously within 1 year combined with male infertility due to partial globozoospermia.[ncbi.nlm.nih.gov]

  • Oligospermia

    (odds ratio 1.3) and morbidly obese (odds ratio 2.0), but the cause of this is unknown. [13] It found no significant relation between oligospermia and being underweight.[en.wikipedia.org] Identical twin brothers presented with oligospermia, small testes, normal male phenotypes, elevated serum luteinizing hormone levels, and normal or elevated serum testosterone[ncbi.nlm.nih.gov] Therefore, episodic luteinizing hormone (LH) was studied in five males with IO and normal T and compared to six normal control males.[ncbi.nlm.nih.gov]

  • Cryptorchidism

    BACKGROUND: Maternal gestational smoking, diabetes, alcohol drinking, and pre-pregnancy obesity are thought to increase the risk of cryptorchidism in newborn males, but the[ncbi.nlm.nih.gov] Tests include observable lack of testes, low testosterone levels (typical female levels), elevated follicle stimulating hormone and luteinizing hormone levels, XY karyotype[en.wikipedia.org] […] or low birth infants -defect: abdominal cavity, abdominal wall, inguinal canal Causes and Risk Factors Cryptorchidism -idiopathic -environmental disruptors -diabetes and obesity[quizlet.com]

  • Orchitis

    Fecal transplant is used to treat gut infections and is now being studied as a treatment for obesity, urinary tract infections, irritable bowel syndrome and more.[nytimes.com] […] in mumps orchitis, have found low testosterone levels, elevated luteinizing hormone (LH) levels and an exaggerated pituitary response to LH-releasing hormone stimulation[jpbsonline.org] Whether scrotal hernias and obese patients are suitable depends entirely upon the surgeon’s familiarity with the technique [ 80, 241 ].[dx.doi.org]

  • Hyperprolactinemia

    RESULTS: of the 71 patients evaluated, most were obese women with macroprolactinomas.[ncbi.nlm.nih.gov] Thus, sustained hyperprolactinemia disrupts the normal pulsatile secretion of GnRH and luteinizing hormone (LH), resulting in low estrogen levels and menstrual irregularities[journals.lww.com] So far, sibutramine, a sympathomimetic drug used in the management of obesity, was not described to be associated with altered prolactin levels.[ncbi.nlm.nih.gov]

  • Sertoli Cell-Only Syndrome

    Klinefelter syndrome. 0001939 Abnormality of the thorax Abnormality of the chest 0000765 Gynecomastia Enlarged male breast 0000771 Male-limited autosomal dominant 0001475 Obesity[rarediseases.info.nih.gov] Plasma testosterone, LH (luteinizing hormone), and FSH (follicle-stimulating hormone) measurements are helpful in separating these conditions.[taldon.org] With hyalinization of the seminiferous tubules LH and FSH are elevated, and plasma testosterone is low or borderline normal.[taldon.org]

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