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21 Possible Causes for Lymphadenopathy, Mutation in the WWOX Gene

  • Epithelial Ovarian Cancer

    TP53 and PTEN are among the best known tumor suppressor genes involved in EOC pathogenesis, but mutations have also been found in genes OPCML and WWOX, among others.[symptoma.com]

  • Primary Effusion Lymphoma

    In PEL the p53 and PTEN genes are rarely mutated. P53 mutations accumulate after chemotherapy ( Petre et al., 2007 ; Chen et al., 2010 ).[journal.frontiersin.org] It usually occurs as a massive, serosal effusion without tumoral masses and lymphadenopathies.[ncbi.nlm.nih.gov] The patient did not have any significant peripheral or axial lymphadenopathy, which made the diagnosis difficult in absence of histopathology.[ncbi.nlm.nih.gov]

  • Esophageal Carcinoma

    Copy-number analysis revealed higher rates of deletions of putative fragile site genes FHIT or WWOX, suggestive of differences in the underlying genomic instability between[nature.com] The initial chest CT scan showed gastroesophageal (GE) junction wall thickening and regional lymphadenopathy.[ncbi.nlm.nih.gov] […] cancer which may cause a patient to present to a doctor include: Dysphagia Weight loss Loss of appetite Odynophagia Hoarseness Melaena Retrosternal pain Intractable hiccups Lymphadenopathy[patient.info]

  • Severe Neonatal-Onset Encephalopathy with Microcephaly

    Homozygous and compound heterozygous mutations in the WWOX gene (16q23) have been found in several families.[disorders.eyes.arizona.edu] Hypogonadism. [69] [70] Lymphadenopathy. Rosai-Dorfman sinus histiocytosis with massive lymphadenopathy. [69] [70] [71] Short stature. Arthralgias.[autoinflammatory-search.org] Generalized lymphadenopathy and hepatosplenomegaly often occur.[merckmanuals.com]

  • Autosomal Recessive Deafness 76

    The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain. 2014;137:411–9.[cerebellumandataxias.biomedcentral.com] Thiamine-responsive megaloblastic anemia syndrome AR 14 51 SLC26A4 Deafness, Pendred syndrome, Enlarged vestibular aqueduct AR 181 548 SLC26A5 Deafness AR 2 7 SLC29A3 Histiocytosis-lymphadenopathy[blueprintgenetics.com]

  • Dursun Syndrome

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] Abdominal ultrasonography (USG) showed mild hepatosplenomegaly and multiple reactive para-aortic lymphadenopathies.[lungindia.com] Drouot N, Renaud M, Klein FA, Anheim M, Tranchant C, Mignot C, Mandel JL, Bedford M, Bauer P, Salih MA, Schule R, Schols L, Aldaz CM, Koenig M タイトル The tumour suppressor gene[genome.jp]

  • Myelocerebellar Disorder

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] Lutz–Lewandowsky epidermodysplasia verruciformis Ly Lye–Lyg • Lym • Lyn–Lys Lye–Lyg Lyell's syndrome Lygophobia Lym Lyme Lyme disease Lymp Lymph Lymph node neoplasm Lympha–Lymphe Lymphadenopathy[sosu.us] Drouot N, Renaud M, Klein FA, Anheim M, Tranchant C, Mignot C, Mandel JL, Bedford M, Bauer P, Salih MA, Schule R, Schols L, Aldaz CM, Koenig M タイトル The tumour suppressor gene[genome.jp]

  • Spinocerebellar Ataxia Type 10

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] Get cytopenias but proliferation of lymphocytes (lymphadenopathy, splenometaly, lymphoma). Cd25 Il2 receptor, on treg.[studystack.com] Drouot N, Renaud M, Klein FA, Anheim M, Tranchant C, Mignot C, Mandel JL, Bedford M, Bauer P, Salih MA, Schule R, Schols L, Aldaz CM, Koenig M タイトル The tumour suppressor gene[genome.jp]

  • Carcinoma

    Copy-number analysis revealed higher rates of deletions of putative fragile site genes FHIT or WWOX , suggestive of differences in the underlying genomic instability between[nature.com] Cervical lymphadenopathy is the initial presentation in many patients, and the diagnosis of NPC is often made by lymph node biopsy.[ojrd.biomedcentral.com] Staging For most patients with NMSC, no formal staging beyond clinical examination for lymphadenopathy is required [ 5 ].[patient.info]

  • Autosomal Dominant Spastic Paraplegia Type 8

    Koenig, The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain, 2014. 137(Pt 2): p. 411-9.[hih-tuebingen.de] Neuropathy associated with polyclonal gammopathy : Angioimmunoblastic lymphadenopathy with dysproteinemia is often manifested by widespread lymphadenopathy.[neuroweb.us] Castleman disease may be associated with lymphadenopathy and plasma-cell dyscrasia.[neuroweb.us]

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