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957 Possible Causes for Lymphadenopathy, Pancytopenia, Splenomegaly

  • Malignant Neoplasm

    To date, phenytoin-induced nasopharyngeal lymphadenopathy has not previously been reported in the literature.[ncbi.nlm.nih.gov] After 15 months a diagnosis of urothelial carcinoma of the bladder was made; after a further 6 months pneumonitis and pancytopenia developed.[ncbi.nlm.nih.gov] She was discharged one month later in poor condition with the principal diagnosis of hemorrhage/ pancytopenia, and a secondary diagnosis of metastatic head and neck cancer[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Based on these findings, we diagnosed the patient with systemic lymphadenopathy due to HCL.[ncbi.nlm.nih.gov] Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] Hairy cell leukemia typically presents with pancytopenia and often mimics aplastic anemia.[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    Lymphadenopathy may or may not be present. Stage III: Absolute lymphocytosis with anemia is present. Hepatosplenomegaly and lymphadenopathy may or may not be present.[symptoma.com] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov]

  • T-cell Acute Lymphoblastic Leukemia

    In comparison, patients 16 to 60 years old (n 21) more commonly had an anterior mediastinal mass (8 [38%]), hepatosplenomegaly (10 [48%]), and lymphadenopathy (16 [76%]).[academic.oup.com] Clinical examination may reveal splenomegaly and lymphadenopathy.[symptoma.com] The patient was a 16-year-old boy who presented with septic shock and pancytopenia, likely precipitated by an acute parvovirus B19 infection.[ncbi.nlm.nih.gov]

  • Hypersplenism

    Always remember to check for any accompanying lymphadenopathy and/or features of liver disease. Investigations Liver biopsy. Bone marrow biopsy. Lymph node biopsy.[patient.info] While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[ncbi.nlm.nih.gov] Pancytopenia can be limited by reducing the volume of the functional spleen.[ncbi.nlm.nih.gov]

  • Niemann-Pick Disease

    A disturbance of sphingolipid metabolism characterised by enlargement of liver and spleen, anaemia, cherry red spot of the macula with progressive blindness, lymphadenopathy[whonamedit.com] Common disease-related morbidities included splenomegaly (96.6%), hepatomegaly (91.4%), liver dysfunction (82.6%), and pulmonary disease (75.0%).[ncbi.nlm.nih.gov] Patients with type B NPD have minimal neurologic involvement but pancytopenia is common.[symptoma.com]

  • Brucellosis

    Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[ncbi.nlm.nih.gov] The most frequent admission symptoms and findings of the patients with pancytopenia were fever (75%), fatigue (50%), splenomegaly (75%), and hepatomegaly (41%).[ncbi.nlm.nih.gov] One patient presented with bilateral lymphadenopathy, and the other exhibited unilateral, left-side hilar lymphadenopathy.[academic.oup.com]

  • Adult-Onset Still Disease

    Other common manifestations of AOSD are lymphadenopathy, hepatosplenomegaly, muscle aches, and pharyngitis.[symptoma.com] […] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly[ncbi.nlm.nih.gov] This disorder is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms.[ncbi.nlm.nih.gov]

  • Follicular Lymphoma

    The patient did not have any significant peripheral or axial lymphadenopathy, which made the diagnosis difficult in absence of histopathology.[ncbi.nlm.nih.gov] Splenic infiltration of lymphoma cells may cause splenomegaly in many cases.[ncbi.nlm.nih.gov] This patient was a 58 years old with generalized lymphadenopathy and Ann Arbor Stage III disease.[ncbi.nlm.nih.gov]

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