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652 Possible Causes for Lymphadenopathy, Pancytopenia, Splenomegaly

  • Primary Myelofibrosis

    Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Chronic Lymphocytic Leukemia

    Lymphadenopathy may or may not be present. Stage III: Absolute lymphocytosis with anemia is present. Hepatosplenomegaly and lymphadenopathy may or may not be present.[symptoma.com] One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Based on these findings, we diagnosed the patient with systemic lymphadenopathy due to HCL.[ncbi.nlm.nih.gov] Most patients are middle-aged to elderly adults and present with splenomegaly and pancytopenia.[icd9data.com] We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.[ncbi.nlm.nih.gov]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Petechiae, ecchymoses, and lymphadenopathy are remarkable findings on the physical exam in the later stages. The disease progresses towards a blast crisis.[symptoma.com] Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant.[ncbi.nlm.nih.gov] […] included thrombocytopenia (n 8), diarrhea (n 3), alanine aminotransferase elevation (n 3), aspartate aminotransferase elevation (n 2), dyspnea (n 2), neutropenia (n 2), pancytopenia[bloodjournal.org]

  • B-Precursor Acute Lymphoblastic Leukemia

    She displayed hepatosplenomegaly and pleural and abdominal effusions without lymphadenopathy. Lactate dehydrogenase (10,554 U/L; normal range 106–211 U/L) was elevated.[journals.lww.com] 64.0%) 66 (66%) 62 (%) 0.556 Bleeding 96 (48.0%) 45 (45%) 51 (51%) 0.396 Lymphadenopathy 112 (56.0%) 53 (53%) 59 (59%) 0.393 Hepatomegaly 84 (42.0%) 46 (46%) 38 (38%) 0.252 Splenomegaly[omicsonline.org] B-precursor acute lymphoblastic leukemia is diagnosed with a standard complete blood count (CBC), which will reveal pancytopenia.[symptoma.com]

  • Familial Myelofibrosis

    Amelioration of splenomegaly and anaemia was also observed in mice treated with Elo and Rom than Rom alone.[jshem.or.jp] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov] Pancytopenia and leukoerythroblastosis require further clarification and should prompt a bone marrow biopsy.[symptoma.com]

  • T-cell Acute Lymphoblastic Leukemia

    In comparison, patients 16 to 60 years old (n 21) more commonly had an anterior mediastinal mass (8 [38%]), hepatosplenomegaly (10 [48%]), and lymphadenopathy (16 [76%]).[academic.oup.com] Clinical examination may reveal splenomegaly and lymphadenopathy.[symptoma.com] The patient was a 16-year-old boy who presented with septic shock and pancytopenia, likely precipitated by an acute parvovirus B19 infection.[ncbi.nlm.nih.gov]

  • Aggressive Systemic Mastocytosis

    Abstract A 43 year-old woman presented with fever, abdominal pain, epato-splenomegaly, ascites, cholestasis, anemia, thrombocytopenia and previous diagnosis of sclerosing[ncbi.nlm.nih.gov] […] organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia to more or less marked pancytopenia[orpha.net] Retro-orbital injections of P815 NT cells in syngeneic DBA/2 mice resulted in rapid development of aggressive SM within 13-16 days characterized by splenomegaly, extramedullary[ncbi.nlm.nih.gov]

  • Q Fever

    Meningoencephalitis, thyroiditis, pericarditis, myocarditis, mesenteric lymphadenopathy, hemolytic anemia, and nephritis are rare manifestations.[ncbi.nlm.nih.gov] This case describes a man who, after extensive investigation for splenomegaly and pancytopenia by several specialties, was finally diagnosed with Q fever endocarditis after[ncbi.nlm.nih.gov] Q fever and lymphadenopathy: report of four new cases and review. Eur J Clin Microbiol Infect Dis 2004;23:759–64. Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A.[cdc.gov]

  • Malignant Histiocytosis

    Four months after the operation, skin induration on the neck and anterior thoracic wall and systemic lymphadenopathy were noted.[ncbi.nlm.nih.gov] The long duration of massive splenomegaly suggests that this patient could represent a chronic form of MH.[ncbi.nlm.nih.gov] […] pancreas at initial presentation is exceptional, this entity should be included in the differential diagnosis of acute pancreatitis, especially when hepatosplenomegaly and pancytopenia[ncbi.nlm.nih.gov]

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