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40 Possible Causes for Lymphadenopathy, Polyclonal Hyperglobulinemia

  • Rosai-Dorfman Disease

    Walker PR, Rosai J, Dorfman RF (1981) The osseous manifestations of sinus histiocytosis with massive lymphadenopathy.[springerlink.com] hyperglobulinemia.[ncbi.nlm.nih.gov] The typical clinical features of this disease include bilateral painless lymphadenopathy, fever, and polyclonal hyperglobulinemia.[jdrntruhs.org]

  • Castleman Disease

    The remaining 6 referral cases showed morphologic features consistent with reactive lymphadenopathy.[ncbi.nlm.nih.gov] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] , hypoalbuminemia, polyclonal hypergammaglobulinemia, leukocytosis, thrombocytosis or splenomegaly. 1,4 In contrast to the localized form, the clinical course of the multicentric[scielo.br]

  • Multicentric Castleman's Disease

    In this study, we examined clinical and pathologic findings of nine patients with systemic IgG4-related lymphadenopathy.[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org] Patients with MCD may reveal raised serum C-reactive protein level, polyclonal hyperglobulinemia, anemia of microcytic hypochromic nature, low albumin level, and high cholesterol[lungindia.com]

  • Angioimmunoblastic Lymphadenopathy

    A 20-year-old man with ulcerative colitis was admitted because of fever, eruption and lymphadenopathy. He had started taking salazosulfapyridine one month previously.[ncbi.nlm.nih.gov] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[emedicine.medscape.com] Both patients fulfilled the diagnostic criteria for angioimmunoblastic lymphadenopathy. We present the two case histories and review the current literature.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com] Abdominal examination reveals splenomegaly, palpable 8 cm. below the costal margin without hepatomegaly CT scans of the chest, abdomen, and pelvis reveal moderate mediastinal lymphadenopathy[targetedonc.com]

  • H Syndrome

    […] combination of features from 2 or more of four histiocytic disorders, originally thought to be distinct: Faisalabad histiocytosis (FHC), sinus histiocytosis with massive lymphadenopathy[uniprot.org] The buildup often occurs in the lymph nodes , leading to swelling of the lymph nodes (lymphadenopathy).[ghr.nlm.nih.gov] Rosai-Dorfman disease (RDD) is a rare, sporadic histiocytic disorder characterized by painless but protracted lymphadenopathy. Its etiology remains unclear.[ncbi.nlm.nih.gov]

  • Autoimmune Pancreatitis

    Therefore, this patient was diagnosed with AIP associated with portal hypertension, systemic lymphadenopathy, and splenomegaly.[ncbi.nlm.nih.gov] hyperglobulinemia.[hematologyandoncology.net] We report a 62-year-old man with obstructive jaundice with pre-existent submandibular lymphadenopathy.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Autoimmune Lymphoproliferative Syndrome Type 1

    In conclusion; in all patients with massive lymphadenopathy and hepatosplenomegay; especially with cytopenia; ALPS should be considered.[ncbi.nlm.nih.gov] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[icd10coded.com] We describe a case of a 41-year-old man with fever, hepatosplenomegaly, multiple lymphadenopathy, autoimmune haemolytic anaemia and severe thrombocytopenia.[ncbi.nlm.nih.gov]

  • Polyclonal Hypergammaglobulinemia

    References 1 Idiopathic plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia: a syndrome related to giant lymph node hyperplasia of plasma cell type , J Jpn[academic.oup.com] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[icd10coded.com] Idiopathic plasmacytic lymphadenopathy (IPL) with polyclonal hypergammaglobulinemia has been proposed as a new disease entity resembling the plasma cell type of multicentric[ncbi.nlm.nih.gov]

  • IgG4-Related Retroperitoneal Fibrosis

    Twenty-four other IgG4-related diseases were found to be associated with IgG4-related RF in nine patients (autoimmune pancreatitis (n 2), sialadenitis (n 4), dacryoadenitis (n 5), lymphadenopathy[ncbi.nlm.nih.gov] hyperglobulinemia.[hematologyandoncology.net] Up to 40–80% of patients with IgG4-related disease have lymphadenopathy.[dermnetnz.org]

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