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40 Possible Causes for Lymphadenopathy, Polyclonal Hyperglobulinemia

  • Rosai-Dorfman Disease

    Walker PR, Rosai J, Dorfman RF (1981) The osseous manifestations of sinus histiocytosis with massive lymphadenopathy.[] hyperglobulinemia.[] The typical clinical features of this disease include bilateral painless lymphadenopathy, fever, and polyclonal hyperglobulinemia.[]

  • Castleman Disease

    The remaining 6 referral cases showed morphologic features consistent with reactive lymphadenopathy.[] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[] , hypoalbuminemia, polyclonal hypergammaglobulinemia, leukocytosis, thrombocytosis or splenomegaly. 1,4 In contrast to the localized form, the clinical course of the multicentric[]

  • Multicentric Castleman's Disease

    In this study, we examined clinical and pathologic findings of nine patients with systemic IgG4-related lymphadenopathy.[] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[] Patients with MCD may reveal raised serum C-reactive protein level, polyclonal hyperglobulinemia, anemia of microcytic hypochromic nature, low albumin level, and high cholesterol[]

  • Angioimmunoblastic Lymphadenopathy

    A 20-year-old man with ulcerative colitis was admitted because of fever, eruption and lymphadenopathy. He had started taking salazosulfapyridine one month previously.[] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[] Both patients fulfilled the diagnostic criteria for angioimmunoblastic lymphadenopathy. We present the two case histories and review the current literature.[]

  • Primary Myelofibrosis

    Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[] Abdominal examination reveals splenomegaly, palpable 8 cm. below the costal margin without hepatomegaly CT scans of the chest, abdomen, and pelvis reveal moderate mediastinal lymphadenopathy[]

  • H Syndrome

    […] combination of features from 2 or more of four histiocytic disorders, originally thought to be distinct: Faisalabad histiocytosis (FHC), sinus histiocytosis with massive lymphadenopathy[] The buildup often occurs in the lymph nodes , leading to swelling of the lymph nodes (lymphadenopathy).[] Rosai-Dorfman disease (RDD) is a rare, sporadic histiocytic disorder characterized by painless but protracted lymphadenopathy. Its etiology remains unclear.[]

  • Autoimmune Pancreatitis

    Therefore, this patient was diagnosed with AIP associated with portal hypertension, systemic lymphadenopathy, and splenomegaly.[] hyperglobulinemia.[] We report a 62-year-old man with obstructive jaundice with pre-existent submandibular lymphadenopathy.[]

  • Autosomal Dominant Autoimmune Lymphoproliferative Syndrome Type 1

    In conclusion; in all patients with massive lymphadenopathy and hepatosplenomegay; especially with cytopenia; ALPS should be considered.[] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[] We describe a case of a 41-year-old man with fever, hepatosplenomegaly, multiple lymphadenopathy, autoimmune haemolytic anaemia and severe thrombocytopenia.[]

  • Polyclonal Hypergammaglobulinemia

    References 1 Idiopathic plasmacytic lymphadenopathy with polyclonal hyperimmunoglobulinemia: a syndrome related to giant lymph node hyperplasia of plasma cell type , J Jpn[] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[] Idiopathic plasmacytic lymphadenopathy (IPL) with polyclonal hypergammaglobulinemia has been proposed as a new disease entity resembling the plasma cell type of multicentric[]

  • IgG4-Related Retroperitoneal Fibrosis

    Twenty-four other IgG4-related diseases were found to be associated with IgG4-related RF in nine patients (autoimmune pancreatitis (n 2), sialadenitis (n 4), dacryoadenitis (n 5), lymphadenopathy[] hyperglobulinemia.[] Up to 40–80% of patients with IgG4-related disease have lymphadenopathy.[]

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