Lymphocytosis: Causes & Reasons

Possible Causes for Lymphocytosis

An atypical lymphocytosis of at least 20 percent or atypical lymphocytosis of at least 10 percent plus lymphocytosis of at least 50 percent strongly supports the diagnosis [ncbi.nlm.nih.gov]

Lymph node biopsy was performed and he was diagnosed as atypical infectious mononucleosis (absence of fever, pharyngitis, lymphocytosis and negative atypical lymphocytosis [ncbi.nlm.nih.gov]

Characterized by the classic triad of fever, pharyngitis, and lymphadenopathy, along with atypical lymphocytosis. Often subclinical in young children. [us.bestpractice.bmj.com]

Chronic Lymphocytic Leukemia

Low-count (LC) MBL is recognized in general population studies and it is not associated with lymphocytosis. [ncbi.nlm.nih.gov]

Rai classification Stage 0: Only lymphocytosis is present i.e >15,000 mm3. Stage I: Lymphocytosis along with lymphadenopathy is present. [symptoma.com]

[…] in the blood and marrow only (survival > 120 months) Stage I lymphocytosis and adenopathy (survival ~ 95 months) Stage II lymphocytosis, splenomegaly and/or hepatomegaly [flexikon.doccheck.com]

Acute Infectious Lymphocytosis

A case of acute infectious lymphocytosis in an otherwise healthy 2-year-old child is reported. [ncbi.nlm.nih.gov]

AIL means Acute Infectious Lymphocytosis What is the abbreviation for Acute Infectious Lymphocytosis? [acronymsandslang.com]

Case reports are presented of 5 cases of acute infectious lymphocytosis in siblings, ages 2¼-10 years. [bloodjournal.org]

Prolymphocytic Leukemia

This patient's condition was diagnosed as T-cell prolymphocytic leukemia based on the findings of lymphocytosis, abnormal immunophenotype, hepatosplenomegaly, lymphadenopathy [ncbi.nlm.nih.gov]

T-cell prolymphocytic leukemia (T-PLL) is an uncommon chronic lymphoproliferative disorder characterized by lymphadenopathy, splenomegaly, and lymphocytosis. [ncbi.nlm.nih.gov]

Both disorders have an aggressive clinical course, lymphocytosis with characteristic morphology, lymphadenopathy, hepatomegaly, characteristic cytogenetic abnormalities and [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

We report the simultaneous presence of hairy cell leukemia, monoclonal B-cell lymphocytosis, and alpha beta CD4(++) /CD8(+) T-cell large granular lymphocytosis in a 63-year-old [ncbi.nlm.nih.gov]

A 67-year-old male was admitted because of lymphocytosis and huge splenomegaly. [ncbi.nlm.nih.gov]

We report a case of a 53-year-old man who had refractory thrombocytopenia and lymphocytosis for 8 years. [ncbi.nlm.nih.gov]

Lymphocytic Hypereosinophilic Syndrome

In that lymphocytosis, there is almost 2% of B-cells. G (400x, TDT) confirms the immature cells. They are immature neoplastic B-cells. [oatext.com]

There were no mast cell aggregates or lymphocytosis. [bloodresearch.or.kr]

Pertussis

In this age group, high mortality and morbidity have been linked to the effects of the pertussis toxin, including lymphocytosis, pulmonary hyperviscosity and pulmonary hypertension [ncbi.nlm.nih.gov]

However, occasional apneic episodes with cyanosis and peripheral lymphocytosis suggested neonatal pertussis and prompted us to examine the presence of Bordetella pertussis [ncbi.nlm.nih.gov]

However, occasional apneic episodes with cyanosis and peripheral lymphocytosis prompted us to examine the presence of Bordetella pertussis, which remains a significant cause [ncbi.nlm.nih.gov]

Anicteric Viral Hepatitis

(see liver tests notes for explanation) The white cell count is usually normal but will show a degree of lymphocytosis This means that the lymphocytes (which normally make [almostadoctor.co.uk]

Mild lymphocytosis is common. Pure red cell aplasia and pancytopenia may very rarely occur. Imaging Ultrasound may, rarely, be needed to exclude other diseases. [patient.info]

In this context, EBV hepatitis may be suggested by the presence of lymphocytosis and splenomegaly. [wjgnet.com]

Massive Hepatic Necrosis

Abstract Cytomegalovirus Mononucleosis is an acute febrile illness characterized by atypical lymphocytosis (1). [annals.org]

Lymphocytosis into the ducts was not seen. D. Ballooned hepatocytes and dilated canaliculi were seen. E. [librepathology.org]

[…] lobular polymorphonuclear cytosis, (3) acidophilic bodies in necrotic areas, (4) degree of inflammation in portal triads, (5) lobular lymphocytes is, and (6) portal triad lymphocytosis [nap.edu]

Waldenstrom Macroglobulinemia

The presence of small lymphocytes in serous cavity fluid can pose great difficulty in the differentiation between a low-grade lymphoproliferative disorder and reactive lymphocytosis [ncbi.nlm.nih.gov]

Patients with MYD88 WT CXCR4 WT who typically have peripheral lymphocytosis had intermediate levels of increased peripheral lymphocytosis as compared with patients with MYD88 [doi.org]

Patients with MYD88WTCXCR4WT who typically have peripheral lymphocytosis had intermediate levels of increased peripheral lymphocytosis as compared with patients with MYD88L265PCXCR4WT [nejm.org]

Mantle Cell Lymphoma

Asymptomatic lymphocytosis is frequently seen with ibrutinib use in mantle cell lymphoma; however, tumor lysis syndrome is an extremely rare complication. [ncbi.nlm.nih.gov]

with generalized lymphadenopathies in 90%, bone marrow involvement (70%), frequent splenomegaly (50%), hepatomegaly (30%), and gastro-intestinal involvement (20%), and lymphocytosis [atlasgeneticsoncology.org]

[…] t(14;18) t(11;18) t(11;14) t(8;14) Board review style question #2 Plot 1 Plot 2 Plot 3 Plot 4 A 74 year old man has presented with an absolute lymphocytosis (6 - 7x103 / μL [pathologyoutlines.com]

Addison Disease

[…] to loss of production of the hormone aldosterone hyperkalemia (raised blood potassium levels), also due to loss of production of the hormone aldosterone eosinophilia and lymphocytosis [web.archive.org]

[…] serum potassium Elevated BUN, creatinine, calcium, thyroid-stimulating hormone (TSH) Hypoglycemia when fasting Metabolic acidosis Moderate neutropenia Eosinophilia Relative lymphocytosis [unboundmedicine.com]

FBC - there may be anaemia, mild eosinophilia and lymphocytosis. Glucose - often low in children. LFTs - may be raised liver transaminases. [patient.info]

Toxoplasmosis

Some patients with prolonged fever and malaise have lymphocytosis, increased suppressor T-cell counts, and a decreased helper-to-suppressor T-cell ratio. [emedicine.com]

Meningeal Tuberculosis

CSF analysis reveals lymphocytosis, increased protein level and decreased glucose levels. Tuberculous meningitis is caused by Mycobacterium tuberculosis. [radiopaedia.org]

CNS Tuberculosis: A meningeal pattern of spread can occur, and the cerebrospinal fluid typically shows a high protein, low glucose, and lymphocytosis. [library.med.utah.edu]

Acellular CSF in elderly and HIV positive patients have been reported. 49 Lymphocytosis of between 100 and 1000 cells/mm 3 is more usual, although in the first 10 days polymorphonuclear [jnnp.bmj.com]

Follicular Lymphoma

Lymphocytosis was seen in 2 cases. Serum lactate dehydrogenase levels were within normal range in all but one case. [ncbi.nlm.nih.gov]

Phase N/A Learn More » A Study of the Kinetics of Lymphoid Cells in Patients with Monoclonal B-Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic [centerwatch.com]

Marrow involvement common (85% have paratrabecular lymphoid aggregates); with marrow involvement, 40% have tumor cells in blood, which may resemble CLL 10% have peripheral lymphocytosis [pathologyoutlines.com]

Sarcoidosis

The cerebrospinal fluid analysis showed a moderately elevated protein content and a significant lymphocytosis 86.5%. [ncbi.nlm.nih.gov]

Table 3 Investigation and treatment of Hypothalamo-pituitary sarcoid (HPS) Investigations that may help in the diagnosis of HPS Serum and CSF ACE CSF Increased protein Lymphocytosis [dx.doi.org]

[…] immunosuppressive agents Azathioprine Cyclosporin Cyclophosphamide Methotrexate Radiotherapy Investigations that may help in the diagnosis of HPS Serum and CSF ACE CSF Increased protein Lymphocytosis [dx.doi.org]

B-Cell Acute Lymphoblastic Leukemia

Lymphoproliferative disorders (X-linked lymphoproliferative disease Autoimmune lymphoproliferative syndrome) Leukemoid reaction Diffuse infiltrative lymphocytosis syndrome [en.wikipedia.org]

[…] hematopoiesis can be considered "clonal hematopoiesis of indeterminate potential" (CHIP), analogous to monoclonal gammopathy of undetermined significance and monoclonal B-cell lymphocytosis [bloodjournal.org]

In addition, samples that are classified as lymphocytosis contain higher numbers of lymphocytes; however, these samples do not have adequate numbers of precursor B-cells and [jove.com]

Rickettsialpox

Although laboratory tests are not diagnostic, a complete blood count with differential count may reveal leukopenia with relative lymphocytosis, and thrombocytopenia while [symptoma.com]

Bordetella Pertussis

Lymphocytosis is likely due to systemic spread of one or several pertussis exotoxins, possibly Pertussis Toxin itself. [pathwaymedicine.org]

However, occasional apneic episodes with cyanosis and peripheral lymphocytosis suggested neonatal pertussis and prompted us to examine the presence of Bordetella pertussis [ncbi.nlm.nih.gov]

Studies of pertussis in children show absolute lymphocytosis in >50% of patients, and characteristic small, mature lymphocytes with hyperchromatic, cleaved nuclei may account [bloodjournal.org]

Non-Hodgkin Lymphoma

Thrombocytosis and lymphocytosis may also occur. Renal function and electrolytes: obstructive nephropathy, hypercalcaemia. LFTs. Serology: HIV, HTLV-1, hepatitis C. [patient.info]

[…] lymphomatous meningitis GI obstruction, perforation, and bleeding in a patient with GI lymphoma (may also be caused by chemotherapy) Pain secondary to tumor invasion Leukocytosis (lymphocytosis [emedicine.medscape.com]

[…] should include the following: CBC count: May be normal in early-stage disease; in more advanced stages, may demonstrate anemia, thrombocytopenia/leukopenia/pancytopenia, lymphocytosis [emedicine.medscape.com]

COVID-19

Hematological aberrations delineated for the clinical cases of neutrophilia (8%), lymphopenia (34%), thrombocytopenia (36%), and lymphocytosis (11%). [frontiersin.org]

Brucellosis

The WBC count is normal or reduced with relative or absolute lymphocytosis during the acute phase. Serologic testing is not reliable for B. canis. [msdmanuals.com]

The WBC count is normal or reduced with relative or absolute lymphocytosis during the acute phase. Serologic testing is not reliable for C. canis. [msdmanuals.com]

Precursor-Cell Lymphoblastic Leukemia

Lymphoproliferative disorders (X-linked lymphoproliferative disease Autoimmune lymphoproliferative syndrome) Leukemoid reaction Diffuse infiltrative lymphocytosis syndrome [en.wikipedia.org]

A general increase in the number of lymphocytes is known as lymphocytosis, whereas a decrease is known as lymphocytopenia. [en.wikipedia.org]

Individuals showing 13q14 abnormalities have a relatively benign disease that usually manifests as stable or slowly progressive isolated lymphocytosis. [emedicine.com]

Lymphocytic Choriomeningitis

Clues leading to the diagnosis included aseptic meningitis during winter and the finding of hypoglycorrachia and lymphocytosis in the cerebrospinal fluid. [ncbi.nlm.nih.gov]

Aplastic Anemia

Simultaneous Na Hypoplasia Hypogamma and lymphopenia Na None Na Death Na Kristiansen et al. [19] 61 M GS2, pancytopenia 3 years after the onset of thymoma Na Hypoplasia + T lymphocytosis [hindawi.com]

[…] process, a number of diseases should be considered in the differential diagnosis, namely: hypoplastic myelodysplastic syndromes (MDS), hypoplastic AML and ALL, large granular lymphocytosis [nature.com]

Tick-Borne Rickettsiosis

In blood also the moderate leukopenia with an eosinopenia, a neutropenia and a relative lymphocytosis is noted normotsitoz. [bigmed.info]

Primary HIV Infection

Even in the early phases there is often a reduction in CD4 lymphocytes, a CD8 lymphocytosis and a ratio of CD4/CD8 which is low. [patient.info]

Disseminated Tuberculosis

CNS Tuberculosis: A meningeal pattern of spread can occur, and the cerebrospinal fluid typically shows a high protein, low glucose, and lymphocytosis. [library.med.utah.edu]

In view of enlarging liver size and no response to antibiotics, a liver biopsy was performed which showed markedly dilated sinusoids with marked lymphocytosis. [jpma.org.pk]

Graves Disease

Leukopenia with a relative lymphocytosis is not an uncommon blood abnormality in GD, named “Kocher’s blood picture.” [11]. [hindawi.com]

[…] with persistently high TSHR-Ab level after cessation of antithyroid drug. [ 47 ] Associated hematological abnormalities include increased RBC mass, leucopenia with relative lymphocytosis [intechopen.com]

Immune Thrombocytopenic Purpura

[…] return to top Investigations lab investigations diagnostic imaging Lab Investigations CBC thrombocytopenia (often 5,000-75,000) occasional lymphocytosis anemia Peripheral [sharinginhealth.ca]

[…] age 2-6 Adults, age 20-40 Sex (♀:♂ratio) 1:1 3:1 History, recent infection Common Rare Onset Abrupt Insidious Hemorrhagic bullae-oral Present if severe Rare Eosinophilia, lymphocytosis [medical-dictionary.thefreedictionary.com]