Lymphocytes Increased: Causes & Reasons

Possible Causes for Lymphocytes Increased

These mature lymphocytes are increased markedly in number. They are indicative of chronic lymphocytic leukemia, a disease most often seen in older adults. [library.med.utah.edu]

As the number of these abnormal lymphocytes increase in the blood and bone marrow, fewer healthy white blood cells, red blood cells, and platelets are produced. [msdmanuals.com]

In CLL, the lymphocytes produced are abnormal and are not able to fight infection. [msdmanuals.com]

Infectious Mononucleosis

The levels of liver enzymes and atypical lymphocytes increase with age. [ncbi.nlm.nih.gov]

The percentage of CD8+/CD11b- cells was not increased in the atypical lymphocytes. However, CD45RO+ was expressed on 86.3% of CD4+ atypical lymphocytes. [ncbi.nlm.nih.gov]

Early in the course of the mono, blood tests may show an increase in one type of white blood cell (lymphocyte). [rxlist.com]

Waldenstrom Macroglobulinemia

As the numbers of abnormal lymphocytes increase, the spleen and lymph nodes “glands” will enlarge. [leukaemia.org.au]

A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. [profiles.umassmed.edu]

In her bone marrow, increased small lymphocytes were admixed with plasmacytoid lymphocytes and plasma cells. She was diagnosed as having lymphoplasmacytic variant of WM. [ncbi.nlm.nih.gov]

Non-Hodgkin Lymphoma

Over time, the number of abnormal lymphocytes increases and abnormal lymphocytes collect in your lymph nodes, or elsewhere in the body. [aidsmap.com]

In NHL, lymphocytes grow indefinitely, so the number of circulating lymphocytes increases, filling up the lymph nodes and causing them to swell. [medicinenet.com]

In NHL, lymphocytes keep dividing and grow out of the body’s control. [aidsmap.com]

Viral Disease

Blood tests will not show any increase in the white blood cells, which typically occurs with bacterial infections. The numbers of lymphocytes may be increased. [webhealthcentre.com]

COVID-19

Common laboratory findings in COVID-19 are a decreased lymphocyte count and an increased CRP and high-sensitivity C-reactive protein level. [radiologyassistant.nl]

White blood cell count was normal in 14 cases (14/20, 70%), decreased in 4 cases (4/20, 20%), and increased in 2 cases (2/20, 10%); percentage of lymphocyte decreased in 7 [onlinelibrary.wiley.com]

In critical patients, D-dimer value is increased, blood lymphocytes decreased persistently, and laboratory alterations of multiorgan imbalance (high amylase, coagulation disorders [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

Also, as the number of lymphocytes increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. [web.archive.org]

Hairy cell leukemia (HCL) is a type of leukemia where there are increased numbers of abnormal B-lymphocytes, a type of white blood cells What is Leukemia? [medindia.net]

Atypical lymphocytes were stained with tartrate resistant acid phosphatase. [ncbi.nlm.nih.gov]

Prolymphocytic Leukemia

T-cell prolymphocytic leukaemia (T-PLL) is a rare aggressive lymphoid disease featured by a significant increased lymphocyte count and obvious hepatosplenomegaly with poor [ncbi.nlm.nih.gov]

Bone marrow aspiration and biopsy were particulate with an increased cellularity and prominence of small mature lymphocytes accounting for 89% of the cells. [indianjcancer.com]

In addition to the neoplastic lymphocytes, there is an increase in macrophages (CD68-positive). [e-immunohistochemistry.info]

Influenza

A low absolute lymphocyte count on admission is associated with more severe disease and death. [ncbi.nlm.nih.gov]

D‐Dimer, increased serum lactate dehydrogenase and creatinine phospho‐kinase, and hypoalbuminemia. [doi.org]

[…] leukocyte, platelet, and particularly, lymphocyte counts at the time of admission. [doi.org]

Sarcoidosis

While T-lymphocyte function seems to be impaired, a upregulation of B-lymphocytes activity leads to increased production of immuneglobulines (resulting in hypergammaglobulinaemia [flexikon.doccheck.com]

TARC concentrations are known to increase in the serum of sarcoidosis patients; however, its role in the assessment of severity and prognosis of sarcoidosis remains unknown [ncbi.nlm.nih.gov]

[…] protein Lymphocytosis/lymphocyte subpopulations Hypoglycorrhachia ↑ lysozyme and β 2 microglobulin Contrast-enhanced MRI ± gallium scanning Biopsy of lesion Treatment of [doi.org]

Toxoplasmosis

Conversely, during recovery, the complete blood count may reveal an increased number of white blood cells, an indication of the increased activity of the infection fighting [petmd.com]

For example, cats with toxoplasmosis may show an abnormally low number of white blood cells (leukopenia), low neutrophils (neutropenia), and low lymphocytes (lymphopenia) [petmd.com]

[…] capacities to present antigens to CD4+ T lymphocytes. [frontiersin.org]

Immune Thrombocytopenic Purpura

CONCLUSION: ITP is associated with immunity dysfunction denoted by the increase in cytotoxic T lymphocytes and the decrease in natural killer cells. [ncbi.nlm.nih.gov]

Activated natural killer cells, B-lymphocytes and T-lymphocytes are responsible for the production of TNF-β. [oncologynurseadvisor.com]

CONCLUSION: Overall, a phenotype characterized by increased pre-B-cell markers along with decreased T cell immunophenotypic markers was observed in bone marrow lymphocytes [ncbi.nlm.nih.gov]

Graves Disease

Lymphocytes increased to 50 %, with 9 % atypical lymphocytes. The patient was anemic and had slight liver dysfunction. [ncbi.nlm.nih.gov]

The second is due to that overactive immune system: the fat and muscles around the eyes become swollen due to an increase in the number of lymphocytes present and other symptoms [study.com]

It is characterized by orbital pain, lacrimation, irritation, photophobia, increased retro-orbital tissue, exophthalmos, and lymphocytic infiltration of the extraocular muscles [msdmanuals.com]

Addison Disease

[…] number of eosinophils or lymphocytes, two types of white blood cells) metabolic acidosis (increased blood acidity), also due to loss of the hormone aldosterone In suspected [web.archive.org]

[…] eosinophils and lymphocytes Other blood tests that may be performed based on history and physical exam include very long-chain fatty acid levels, DHEA levels, 17-OH progesterone [dovemed.com]

Relative lymphocytosis Eosinophils Increased Imaging X-ray or CT Evidence of Calcification in adrenal area Renal tuberculosis Pulmonary tuberculosis Hyperpigmentation can [msdmanuals.com]

B-Cell Acute Lymphoblastic Leukemia

People who have a sibling, including a twin, with acute lymphocytic leukemia have an increased risk of ALL. [mayoclinic.org]

Delayed development of the immune system due to limited disease exposure may result in excessive production of lymphocytes and increased mutation rate during an illness. [en.wikipedia.org]

Acute lymphoblastic leukemia (ALL) is a type of cancer which causes an increased production of lymphoblasts, which fail to differentiate into mature T or B lymphocytes. [symptoma.com]

Hereditary Spherocytosis

White blood cell count is increased in bacterial infections and lymphocyte count is increased in viral infections. [medicaljoyworks.com]

Precursor-Cell Lymphoblastic Leukemia

A general increase in the number of lymphocytes is known as lymphocytosis, whereas a decrease is known as lymphocytopenia. [en.wikipedia.org]

Medical Definition of acute lymphoblastic leukemia : lymphocytic leukemia that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid [merriam-webster.com]

The increase in the ALC was primarily from activated CTL019 T lymphocytes. Patient 1 was a 7-year-old girl with a second recurrence of ALL. [doi.org]

Hodgkin Lymphoma

Infection : Certain viral and bacterial infections that transform lymphocytes increase the risk, such as the Epstein-Barr virus (EBV), which causes glandular fever. [medicalnewstoday.com]

EBV is a virus that infects B-lymphocytes, causing them to grow and live longer. [lymphoma.ca]

Having a sibling who has had Hodgkin lymphoma increases the risk of someone getting this type of cancer. [kidshealth.org]

Aplastic Anemia

CD3+ T-lymphocyte ratios decreased only in the KQ group, while CD3 + CD4 + CD8 − Tlymphocytes increased only in the KC group after 6 months (P < 0.05). [ncbi.nlm.nih.gov]

[…] leukemia (ALL) and aplastic anaemia (AA) increase and the ratio of OKT4~+ to OKT8~+ decreases significantly, but there is no significant change of T cell subpopulations in [dict.cnki.net]

Increase in stromal cells such as plasma cells, lymphocytes sometimes forming follicles and mast cells are typical but confounding findings. [nature.com]

Mycoplasma Pneumonia

A significantly increased level of IL-2 was found in both pneumonia groups, compared with the control group. [ncbi.nlm.nih.gov]

Increased serum levels of ferritin exert an immunosuppressive effect through the inhibition of lymphocyte proliferation. [respiratory-research.biomedcentral.com]

Compared with at admission, at discharge the MP patients had significantly increased levels of lymphocyte differential (44.3% vs. 28.8%, respectively; p = 0.001), total IgG [bmcpediatr.biomedcentral.com]

Guillain-Barré Syndrome

The percentages of Th1 and Th17 cells in the CD4+ T lymphocyte subsets were significantly decreased, whereas the Th2 and Treg cells were increased in patients after treatment [ncbi.nlm.nih.gov]

An increased lymphocyte count would be inconsistent with GBS and may suggest sarcoidosis, Lyme disease neuropathy, or recent HIV infection [3]. [journalofethics.ama-assn.org]

The changes in CD4+T lymphocyte subsets were correlated with patient MRC score changes. [ncbi.nlm.nih.gov]

Primary HIV Infection

Abstract OBJECTIVE: To investigate if early treatment of primary HIV-1 infection (PHI) reduces viral set point and/or increases CD4 lymphocytes. [ncbi.nlm.nih.gov]

[…] and impair cell-mediated immunity, increasing risk of certain infections and cancers. [msdmanuals.com]

Beta 2 -microglobulin is increased with lymphocyte activation or destruction associated with HIV disease progression. [library.med.utah.edu]

Mantle Cell Lymphoma

Our results revealed a significant increase in natural killer (NK) cells relative to total lymphocytes in lenalidomide responders compared to non-responders that was associated [ncbi.nlm.nih.gov]

In this case we present an old man with concomitant mantle cell lymphoma and large granular lymphocytic leukemia diagnosed by the morphology of the bone marrow aspiration, [ncbi.nlm.nih.gov]

English Lymphocytosis: Laboratory tests may show an increase in white blood cells (called “lymphocytes”) in your blood in the first few weeks of treatment. [mymemory.translated.net]

T-Cell Acute Lymphoblastic Leukemia

People who have a sibling, including a twin, with acute lymphocytic leukemia have an increased risk of ALL. [mayoclinic.org]

Autophagy was also induced in proliferating lymphocytes and in JURKAT and MOLT-4 cell lines. [ncbi.nlm.nih.gov]

Clinicopathologic aspects of E rosette negative T cell acute lymphocytic leukemia: a Pediatric Oncology Group study. J Clin Oncol. 1986;4:170–7. 4. [nature.com]

Multiple Myeloma

The risk of chronic lymphocytic leukemia was only slightly increased ( Table 1 ) when all cases were included. Table 2. Table 2. [doi.org]

Analyzing the CD8 + CD28 - T-cells in detail, increased numbers of these cells were observed in the bone marrow (i.e., tumor microenvironment) of patients with plasma cell [ncbi.nlm.nih.gov]

[…] in the patients with MGUS as compared with white subjects in the Iowa SEER registry from 1973 to 1997. 18 This increased risk was found in all age groups and throughout all [doi.org]

Viral Hepatitis

The risk for intermittent reactivation is increased with immunosuppression. [doi.org]

Circulating lymphocytes, monocytes, and polymorphonuclear leukocytes may serve as the predominant site of viral latency. [doi.org]

Syphilis

Since 2005, the incidence of both primary and secondary syphilis has increased in all the races and ethnicities. [symptoma.com]

Diagnosis is made by combining the positive results of the serology test, an increase in cellularity (more than 10 lymphocytes/mL), and proteins in the CSF (over 40 mg/dL) [scielo.br]

Primary syphilis is characterized by ulceration due to the migration of mononuclear leukocyte infiltration, lymphocytes, and macrophages. [symptoma.com]

Follicular Lymphoma

Given the negative differential outcomes in patients with decreased tumor-infiltrating lymphocytes and increased monocyte/macrophage activation, immunologic approaches in [jco.ascopubs.org]

• Pathogenesis: • Massive infiltration of the bone marrow with immature lymphoid cells (blasts) • Blasts are precursors to T & B lymphocytes • Leads to an increase in the [slideserve.com]

One of the functions of the cell from which these cancers come from, which is a lymphocyte or one of the white cells, is to make antibodies. [patientpower.info]

Viral Pneumonia

Conclusions: The increased levels of NO and IL-17 may be related to dysregulated lymphocytes' immune response in children with influenza A viral pneumonia. [ncbi.nlm.nih.gov]

[…] of peripheral blood CD3+, CD3+CD4+ T lymphocytes, and CD56+CD16+ natural killer (NK) cells than controls (p < 0.05), while CD3+CD8+ and CD4-CD8- (double negative, DN) T lymphocytes [ncbi.nlm.nih.gov]

Lymphocytic Choriomeningitis

[…] has increased awareness of and clinical interest in this pathogen. [ncbi.nlm.nih.gov]

Congenital lymphocytic choriomeningitis virus (LCMV) infection is associated with high mortality and morbidity. [ncbi.nlm.nih.gov]

BACKGROUND: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. [ncbi.nlm.nih.gov]