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352 Possible Causes for Lymphocytes Increased, Prominent Nucleoli

  • Influenza

    These atypical cells were unusually large and had large nuclei, coarse chromatin, and prominent nucleoli.[doi.org] A low absolute lymphocyte count on admission is associated with more severe disease and death.[ncbi.nlm.nih.gov] D‐Dimer, increased serum lactate dehydrogenase and creatinine phospho‐kinase, and hypoalbuminemia.[doi.org]

  • Infectious Mononucleosis

    There is a mixture of cell types, including plasmacytoid cells, and individual cells with prominent nucleoli. Immunohistochemical studies are non-specific.[doi.org] The levels of liver enzymes and atypical lymphocytes increase with age.[ncbi.nlm.nih.gov] The percentage of CD8 /CD11b- cells was not increased in the atypical lymphocytes. However, CD45RO was expressed on 86.3% of CD4 atypical lymphocytes.[ncbi.nlm.nih.gov]

  • Prolymphocytic Leukemia

    This study documents the existence of an unusual leukemic form of mantle cell lymphoma with prominent nucleoli; the clinicopathologic features that distinguish it from other[ncbi.nlm.nih.gov] RATIONALE: T-cell prolymphocytic leukaemia (T-PLL) is a rare aggressive lymphoid disease featured by a significant increased lymphocyte count and obvious hepatosplenomegaly[ncbi.nlm.nih.gov] The prolymphocytes are morphologically characterized by a large nucleus with opened up chromatin and a single centrally placed prominent nucleoli (Figure below).[medical-labs.net]

  • Malignant Neoplasm

    nucleoli, lymph node metastases, and eventually overwhelming local recurrence and nodal metastases, resulting in death.[ncbi.nlm.nih.gov] , have a 22-fold increase in the RR of CNS tumors.[ncbi.nlm.nih.gov] Prominent nucleoli or irregular chomatin distribution within nuclei. Mitoses (especially irregular or bizarre mitoses).[library.med.utah.edu]

  • Hairy Cell Leukemia

    Lymphocytes had large nuclei with prominent nucleoli, heterogeneous appearance, and large cytoplasm with hairy projections.[ncbi.nlm.nih.gov] Hairy cell leukemia (HCL) is a type of leukemia where there are increased numbers of abnormal B-lymphocytes, a type of white blood cells What is Leukemia?[medindia.net] nucleoli May be perinuclear halo in formalin fixed tissue due to abundant cytoplasm Prominent cell borders ("fried egg appearance") with formalin fixation Marked marrow fibrosis[pathologyoutlines.com]

  • Mantle Cell Lymphoma

    Infrequently the cells of mantle cell lymphoma have a different appearance, including finer, powdery chromatin; more prominent nucleoli; more frequent mitotic figures; and[pleiad.umdnj.edu] In this case we present an old man with concomitant mantle cell lymphoma and large granular lymphocytic leukemia diagnosed by the morphology of the bone marrow aspiration,[ncbi.nlm.nih.gov] ( Am J Clin Pathol 2001;115:567 ) Cases with prominent nucleoli resemble AML-M3 ( Am J Clin Pathol 2002;117:246 ) Bone marrow involvement: most of these patients relapse[pathologyoutlines.com]

  • T-cell Acute Lymphoblastic Leukemia

    The malignant lymphoid infiltrate was characterized by blasts, showing scant cytoplasm, irregular hyperchromatic nuclei, and occasional prominent nucleoli.[ncbi.nlm.nih.gov] Autophagy was also induced in proliferating lymphocytes and in JURKAT and MOLT-4 cell lines.[ncbi.nlm.nih.gov] , and finely stippled chromatin Large blasts with convoluted nuclei, abundant clear cytoplasm, and prominent nucleoli Range of blast sizes in any one patient is typical Precursor[surgpathcriteria.stanford.edu]

  • Acute Lymphoblastic Leukemia

    The nuclear chromatin can be fine to clumped, with occasionally prominant nucleoli.[wiki.clinicalflow.com] Medical Definition of acute lymphoblastic leukemia : lymphocytic leukemia that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid[merriam-webster.com] BM touch imprints ( C ) of a case with only a BCL2 rearrangement by FISH showed large neoplastic cells with fine chromatin, prominent nucleoli, and vacuolated basophilic cytoplasm[ajcp.oxfordjournals.org]

  • Acute Infectious Lymphocytosis

    .  Nucleoli become elongated and enlarged. • Scanning Electron Microscope  Reveals a pronounce shape change from round to “hand mirror” shape.  Uropod becomes very prominent[slideshare.net] […] an actual or relative increase in the number of lymphocytes.[medical-dictionary.thefreedictionary.com] The disease is characterized by an increase in the total number of white blood cells in peripheral blood, of which the main increase in lymphocytes, longer duration, mild[healthfrom.com]

  • B-Precursor Acute Lymphoblastic Leukemia

    The nuclear chromatin can be fine to clumped, with occasionally prominant nucleoli.[wiki.clinicalflow.com] Acute lymphoblastic leukemia (ALL) is a type of cancer which causes an increased production of lymphoblasts, which fail to differentiate into mature T or B lymphocytes.[symptoma.com] The reason for the increased risk is as yet unknown but may involve differences in the transcription level of this gene ( 12 ).[pnas.org]

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