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12 Possible Causes for Lymphocytic Infiltrate, Susceptibility to Hematologic Malignancies Increased

  • Common Variable Immunodeficiency

    […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] The synovium was infiltrated by lymphocytes rather than neutrophils.[ncbi.nlm.nih.gov] Immunohistochemical typing of the lymphocytic infiltrate showed that B-cells were almost absent, matching the immunological profile of CVID.[ncbi.nlm.nih.gov]

  • Infective Dermatitis Associated with HTLV-1

    increase the susceptibility to bacterial infections.[htlv.net] We identified a strong lymphocytic infiltrate which did not confine itself to the dermis but extended into the epidermis.[omicsonline.org] Sub-epidermal dense lymphocytic infiltrate with significant epidermotropism (Pautrier’s abscess). CD25 staining is positive.[medicaljournals.se]

  • Oral Candidiasis

    . • The patients who are on immunosuppressive drug regimens or who have HIV infection, cancer, or hematologic malignancies have an increased susceptibility to oral candidiasis[slideshare.net] infiltration in the surrounding connective tissue. [12] Erythematous candidiasis Erythematous candidiasis [Figure 2] clinically presents as localized erythema of the oral[ijdr.in] Labial salivary gland biopsy revealed histologic features similar to those in Sjogren's syndrome.(84) In HIV-SGD, however, the lymphocytic infiltrate is predominantly CD8[hivinsite.ucsf.edu]

  • Rothmund Thomson Syndrome

    Dermis showed pigmentary incontinence and moderate lymphocytic infiltration in the upper dermis with dilatation of blood vessels.[ijdvl.com] DNA helicase dysfunction results in an increased susceptibility to cancer, particularly osteosarcoma and skin cancer. Myelodysplasia and hematologic malignancy are rare.[visualdx.com] infiltrate.[cancerindex.org]

  • Medulloblastoma

    Tumor biopsy 488 days post-HSCT showed infiltration with donor lymphocytes demonstrating graft-versus-tumor (GVT) effect. The patient remained alive 2 years post-HSCT.[ncbi.nlm.nih.gov] Increased susceptibility to certain tumors, including neuroblastoma and some hematological malignancies, is recognized in disorders caused by mutations in genes encoding components[ncbi.nlm.nih.gov] Increased susceptibility to certain tumors (neuroblastoma), hematological malignancies (acute lymphoblastic leukemia, acute myeloid leukemia) or disorders caused by mutations[orpha.net]

  • Splenic Subcapsular Hematoma

    The spleen is very vulnerable to rupture secondary to infiltration of the trabeculae and capsule by atypical lymphocytes.[omicsonline.org] However, splenectomy should be avoided if possible, particularly in children, the elderly, and patients with hematologic malignancy, to avoid the resulting permanent susceptibility[merckmanuals.com] These atypical lymphocytes heavily infiltrate the spleen and, on histological examination, cause a prominence of splenic follicles and a blurring of the splenic architecture[omicsonline.org]

  • Gaucher Disease

    In addition to the classic manifestations, patients suffer from increased susceptibility to hematologic and nonhematologic malignancies.[ncbi.nlm.nih.gov] Immunological abnormalities are also common - eg, hypergammaglobulinaemia, T-lymphocyte deficiency in the spleen and impaired neutrophil chemotaxis.[patient.info] Rarely, pulmonary infiltration by Gaucher cells may lead to overt lung disease. Haematological abnormalities are common - eg, anaemia, thrombocytopenia and leukopenia.[patient.info]

  • Parainfluenza Virus

    malignancy (HM) patients because of their immunocompromised status and susceptibility to lower respiratory tract infections.[ncbi.nlm.nih.gov] Peribronchial lymphocytes may infiltrate the tissue. The host immune response also induces some of the pathological changes.[microbiologybook.org] Advances in diagnostic methods, including polymerase chain reaction, have led to increased identification and awareness of these infections.[ncbi.nlm.nih.gov]

  • Common Variable Immunodeficiency Type 4

    […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] Intestinal lymphocytic infiltration was not included in this category for the statistic determinations.[scitechnol.com] Some patients may suffer with lymphocytic infiltration of tissues, which can cause lymphadenopathy , splenomegaly and hepatomegaly , as well as the formation of granulomas[xpertdox.com]

  • Common Variable Immunodeficiency Type 11

    Schwartz Lymphocytic infiltrative disorders Interstitial lung disease, pp. 293-299 [2.] R.L. Kradin, E.J.[archbronconeumol.org] […] to infections, autoimmune diseases, hematologic malignancy, or death caused by infection in other family members should increase the provider’s index of suspicion for CVID[mdedge.com] CD8 proportions may be predictive markers for polyclonal lymphocytic infiltration and autoimmunity. [26] Those who develop granulomatous lymphocytic interstitial lung disease[emedicine.medscape.com]

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