Possible Causes for lymphopenia Tonsillitis The finding of herpetic tonsillitis is rare. Tonsillectomies are usually done for children with recurrent chronic tonsillitis, while viral throat infections are generally self-limiting. We present two cases: A 5 year-old girl, with atypical hemolytic anemia managed with Eculizumab, who presented with a pharyngeal infection[…] [ncbi.nlm.nih.gov] COVID-19 In 63% of the patients, lymphopenia was observed. Abnormal findings on chest CTs were observed for all 41 patients. [contagionlive.com] […] non-specific: fever myalgia malaise non-productive cough pleuritic pain dyspnea Laboratory tests The most common findings in a study of 138 hospitalized patients were 13: lymphopenia [radiopaedia.org] She was tachypneic (30bpm), with lymphopenia and low oxygen saturation (SpO2 85%). [radiologyassistant.nl] Childhood Hodgkin Lymphoma The complete cell blood count may show neutrophilia or eosinophilia, lymphopenia or monocytosis, anemia or thrombocytopenia. [symptoma.com] Angioimmunoblastic Lymphadenopathy It is characterized by acute onset, severe constitutional symptoms, cervical or generalized lymphadenopathy, lymphopenia, and polyclonal hypergammaglobulinemia, all of which [ncbi.nlm.nih.gov] ( eMedicine ) Laboratory Polyclonal hypergammaglobulinemia and autoimmune hemolytic anemia ( Hsi: Hematopathology, Second Edition, 2012 ) Eosinophilia, thrombocytopenia, lymphopenia [pathologyoutlines.com] Congenital AIDS One of the early clues to an acquired immunodeficiency state is the development of absolute lymphopenia. [hemonc.mhmedical.com] […] secretion of tolerogenic cytokines Cytopenias Decreased cellular immunity and anergy Stress-induced nonspecific immune activation Infectious diseases: HIV infection T-cell lymphopenia [incodom.kr] […] recessive) IL-2RG(X-linked) Oral candidiasis, Pneumocystis jirovecii pneumonia, diarrhea before 6 months, failure to thrive, graft vs host disease, absent thymic shadow, lymphopenia [msdmanuals.com] Acquired Immunodeficiency Syndrome Lymphopenia was not common, as it is in adult patients. [nejm.org] He was hospitalized again in April with fever, splenomegaly, anemia, and lymphopenia. [cdc.gov] Masur et al (2) also reported that lymphocyte dysfunction and lymphopenia were similar in heterosexual and homosexual cases of PCP. [cdc.gov] Intestinal Lymphangiectasia The objective of this study was to better characterize the lymphopenia of PIL-confirmed patients. [ncbi.nlm.nih.gov] […] lymphangiectasia (Waldmann's disease) is an exudative enteropathy characterized by lymph leakage into the small bowel lumen leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia [ncbi.nlm.nih.gov] […] rare disorder characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia [ncbi.nlm.nih.gov] Ehrlichiosis In this study, we compared the immune responses in two patients with mild/non fatal and severe/fatal HME who had marked lymphopenia, thrombocytopenia and elevated liver enzymes [ncbi.nlm.nih.gov] Common laboratory abnormalities included thrombocytopenia (94%), elevated aspartate aminotransferase (90%), elevated alanine aminotransferase (74%), hypoalbuminemia (65%), lymphopenia [ncbi.nlm.nih.gov] Clinical laboratory findings may include thrombocytopenia, lymphopenia, leucopenia, and elevated liver enzymes. [dhs.wisconsin.gov] Cartilage Hair Hypoplasia Here, we present a case of CHH with mild skeletal changes and immunological findings associated with recurrent otitis media, neutropenia, and lymphopenia. [ncbi.nlm.nih.gov] Sixty-two percent of the patients had had lymphopenia and 24% neutropenia. [ncbi.nlm.nih.gov] Irrespective of clinical phenotype, most patients had lymphopenia and reduced lymphocyte proliferation to mitogens in vitro. [ncbi.nlm.nih.gov] Lymphopenia lymphopenia in 10%. [doi.org] There is surprisingly little literature on lymphopenia in SLE, despite its common occurrence in this disorder. 24, 25, 45, 46 Lymphopenia is well known to predispose to infections [doi.org] Lymphopenia was an important risk factor for major infections in this group of Chinese patients in the early stages of SLE. [ncbi.nlm.nih.gov] Idiopathic CD4 Lymphocytopenia It may be discovered that some of the patients diagnosed during infancy with idiopathic T-cell lymphopenia represent the earliest presentation of the idiopathic CD4-cell lymphopenia [frontiersin.org] I would also consider an ANA since SLE may result in lymphopenia. [aaaai.org] Causes of Lymphopenia Lymphopenia can be caused by many conditions, including infection and medication side effect. At times, the condition may only affect lymphocytes. [verywell.com] Chronic Eosinophilic Leukemia As expected, all patients developed lymphopenia during treatment with alemtuzumab. [clincancerres.aacrjournals.org] Severe Combined Immunodeficiency A full blood count revealed profound lymphopenia. The child was diagnosed with adenosine deaminase deficiency, a rare cause of severe combined immunodeficiency (SCID). [ncbi.nlm.nih.gov] METHODS: Between May 1, 2010 and December 31, 2011, the National Taiwan University Hospital Newborn Screening Center screened all newborns for T-cell lymphopenia by measuring [ncbi.nlm.nih.gov] Newborn screening (NBS) for severe combined immunodeficiency (SCID) is now identifying infants with 22q11.2DS due to T cell lymphopenia. [ncbi.nlm.nih.gov] Primary Immune Deficiency Disorder Laboratory investigation showed that our patient had WBC of 9500/uL, lymphopenia (ALC: 600 cells/uL) with low T cells (7 cells/uL), very low both CD4 (4 cells/uL) and CD8 [hindawi.com] Here, the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are associated with loss-of-function of FCHO1 and impaired [nature.com] Features of SCID • Absent tonsils • Small or absent lymph nodes • Absent thymic shadow • Lymphopenias • Decreased Number of T cells • Severe agammaglobulinemia (Swiss type [slideshare.net] Acute Sarcoidosis IgG (approx. 50% of patients) Angiotensin-converting enzyme (ACE) blood levels; may be used to monitor disease activity and therapy Inflammatory markers, possible lymphopenia [amboss.com] Protein-Losing Enteropathy The diagnosis of lupus was established based on the presence of lymphopenia, proteinuria, ANA, and positive autoantibodies (anti-Sm, anti-DNA, and anti-Ro). [ncbi.nlm.nih.gov] It is characterized by dilation and leakage of intestinal lymph vessels leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia. [ncbi.nlm.nih.gov] All patients with PLE had lymphopenia compared with 25% of controls (P .01). [ncbi.nlm.nih.gov] Middle East Respiratory Syndrome All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine [ncbi.nlm.nih.gov] Laboratory analyses showed raised concentrations of lactate dehydrogenase (23 [49%]) and aspartate aminotransferase (seven [15%]) and thrombocytopenia (17 [36%]) and lymphopenia [ncbi.nlm.nih.gov] Lymphopenia was the most common finding in a cohort of 157 patients with SARS. [doi.org] Phlebotomus Fever Infected individuals developed a marked leukopenia characterized by an initial lymphopenia followed by protracted neutropenia. [ncbi.nlm.nih.gov] Laron Syndrome with Immunodeficiency Immunodeficiency is characterized by moderate lymphopenia which leads to recurrent infections of the skin and respiratory tract. [orpha.net] Standard analyses do not usually show any anomalies, but moderate lymphopenia and hypergammaglobulinemia have been reported. [symptoma.com] In patients with STAT5B deficiency, moderate lymphopenia with lack of CD3+, CD4+, and CD8+ T cells, CD4+/CD25+ regulatory T cells, γδ T cells, and NK cells has been described [symptoma.com] Adenosine Deaminase Deficiency She had frequent infections, lymphopenia, and recurrent hepatitis as a child but did relatively well in her second and third decades. [ncbi.nlm.nih.gov] The clinical effects of ADA deficiency are manifest most dramatically in the immune system, where it leads to severe lymphopenia. [ncbi.nlm.nih.gov] A three-yr-old Japanese boy was diagnosed with delayed-onset ADA deficiency because of recurrent bronchitis, bronchiectasia, and lymphopenia. [ncbi.nlm.nih.gov] Leukopenia OBJECTIVE: To systematically review the available evidence to evaluate (1) the prevalence and degree of leukopenia, lymphopenia, and neutropenia in patients with systemic [ncbi.nlm.nih.gov] Lymphopenia and GC use are known risk factors for infections in SLE patients. [consultqd.clevelandclinic.org] Learn about the different types of leukopenia: neutropenia and lymphopenia and their causes. Leukopenia Inside your bones, there are small but productive factories. [study.com] Congenital Chylothorax Lymphopenia lasted for 12 d median (range 4-39 d) and was significantly correlated with the duration of lymph drainage (p 0.001). [ncbi.nlm.nih.gov] Congenital chylothorax: Lymphopenia and high risk of neonatal infections. Acta Paediatr 2004;93:220-4. 4. Dubin PJ, King IN, Gallagher PG. Congenital chylothorax. [jcnonweb.com] All infants suffered from hypoalbuminaemia, electrolyte imbalances, clotting dysfunction, lymphopenia, anaemia and immune deficiency due to chronic loss of immunoglobulins [erj.ersjournals.com] Disseminated Histoplasmosis […] protein - 40 mg/L (normal [7] based on malar rash, photosensitivity, nonerosive arthritis, positive ANA, serositis (pleural effusion), and hematological disorder (leukopenia, lymphopenia [e-ijd.org] Primary Intestinal Lymphangiectasia The objective of this study was to better characterize the lymphopenia of PIL-confirmed patients. [ncbi.nlm.nih.gov] […] lymphangiectasia (Waldmann's disease) is an exudative enteropathy characterized by lymph leakage into the small bowel lumen leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia [ncbi.nlm.nih.gov] […] rare disorder characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia [ncbi.nlm.nih.gov] Activated PI3K-Delta Syndrome Definition A disorder characterized by recurrent respiratory infections, progressive airway damage, lymphopenia, increased circulating transitional B cells, increased immunoglobulin [uniprot.org] Immunologically, patients display lymphopenia, increased transitional B cells, elevated IgM, variable reductions in IgG, and T cell exhaustion. [lifesci.dundee.ac.uk] Description Activated PI3K-delta syndrome (APDS) is a primary immunodeficiency characterized by recurrent respiratory infections, progressive airway damage, lymphopenia, increased [genome.jp] Immunodeficiency Lymphopenia and delayed cutaneous anergy remitted during treatment with a completely FULL TEXT [annals.org] Related Topics: Topics using similar words Narrower Topics: Agammaglobulinemia Common Variable Immunodeficiency Deltaretrovirus Infections Dysgammaglobulinemia HIV Infections Lymphopenia [expertscape.com] AIDS-Related Opportunistic Infections HIV-Associated Lipodystrophy Syndrome HIV Enteropathy HIV Seropositivity HIV Wasting Syndrome Leukocyte-Adhesion Deficiency Syndrome Lymphopenia [ncbi.nlm.nih.gov] Purine-Nucleoside Phosphorylase Deficiency Progressive lymphopenia, ataxia, and developmental delay led to diagnosis. Umbilical cord blood transplantation corrected the immunodeficiency. [ncbi.nlm.nih.gov] There is severe lymphopenia with decreased absolute numbers of T and B lymphocytes. [ncbi.nlm.nih.gov] Lymphopenia, reduced serum uric acid, and abnormal PNP enzymatic activity assist in the diagnosis of PNP-deficient patients. [ncbi.nlm.nih.gov] Immunodeficiency Type 23 Immunodeficiency Decreased immune function 0002721 Intellectual disability Mental deficiency Mental retardation Mental retardation, nonspecific Mental-retardation [ more ] 0001249 Lymphopenia [rarediseases.info.nih.gov] We identified three unrelated children with recurrent infections, congenital leukopenia including neutropenia, B and T cell lymphopenia, and progression to bone marrow failure [f1000.com] […] received hematopoietic stem cell transplantation of cord blood and bone marrow from matched related donors; both had successful engraftment and correction of neutropenia and lymphopenia [f1000.com] Cernunnos-XLF Deficiency […] context to support the T-cell lymphopenia. [aacc.org] Its clinical manifestations are growth retardation, dysmorphic features, malformations, and severe B- and T-cell lymphopenia. [ncbi.nlm.nih.gov] CHARGE syndrome, and idiopathic T-cell lymphopenia. [aacc.org] Good's Syndrome Evaluation of his immune status during the terminal illness revealed hypogammaglobulinemia and lymphopenia consistent with a diagnosis of Good's syndrome (immunodeficiency [ncbi.nlm.nih.gov] Although the cryptococcus is a recognised fungal pathogen in patients with other causes of CD4 T cell lymphopenia, surprisingly this complication has not been reported in [ncbi.nlm.nih.gov] […] is necessary to search for Good's syndrome by practicing chest CT scan, looking for thymoma, which is constant, and peripheral lymphocytes phenotyping looking for B cell lymphopenia [ncbi.nlm.nih.gov]
