Lymphopenia: Causes & Reasons

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Possible Causes for Lymphopenia

Cartilage Hair Hypoplasia

Laboratory studies will reveal transient macrocytic anemia, lymphopenia with a decreased CD4+/CD8+ T-cell count, and neutropenia. [symptoma.com]

Here, we present a case of CHH with mild skeletal changes and immunological findings associated with recurrent otitis media, neutropenia, and lymphopenia. [ncbi.nlm.nih.gov]

Sixty-two percent of the patients had had lymphopenia and 24% neutropenia. [ncbi.nlm.nih.gov]

Congenital AIDS

One of the early clues to an acquired immunodeficiency state is the development of absolute lymphopenia. [hemonc.mhmedical.com]

[…] secretion of tolerogenic cytokines Cytopenias Decreased cellular immunity and anergy Stress-induced nonspecific immune activation Infectious diseases: HIV infection T-cell lymphopenia [incodom.kr]

[…] recessive) IL-2RG(X-linked) Oral candidiasis, Pneumocystis jirovecii pneumonia, diarrhea before 6 months, failure to thrive, graft vs host disease, absent thymic shadow, lymphopenia [msdmanuals.com]

Ehrlichiosis

Clinical laboratory findings may include thrombocytopenia, lymphopenia, leucopenia, and elevated liver enzymes. [dhs.wisconsin.gov]

In this study, we compared the immune responses in two patients with mild/non fatal and severe/fatal HME who had marked lymphopenia, thrombocytopenia and elevated liver enzymes [ncbi.nlm.nih.gov]

Common laboratory abnormalities included thrombocytopenia (94%), elevated aspartate aminotransferase (90%), elevated alanine aminotransferase (74%), hypoalbuminemia (65%), lymphopenia [ncbi.nlm.nih.gov]

Childhood Hodgkin Lymphoma

The complete cell blood count may show neutrophilia or eosinophilia, lymphopenia or monocytosis, anemia or thrombocytopenia. [symptoma.com]

Angioimmunoblastic Lymphadenopathy

It is characterized by acute onset, severe constitutional symptoms, cervical or generalized lymphadenopathy, lymphopenia, and polyclonal hypergammaglobulinemia, all of which [ncbi.nlm.nih.gov]

Lymphopenia was seen in 2 patients.Â 4. Lymphocytes with azure granules which encompass T-suppressors were found to exceed normal values by a factor of 15.Â 5. [scipers.com]

( eMedicine ) Laboratory Polyclonal hypergammaglobulinemia and autoimmune hemolytic anemia ( Hsi: Hematopathology, Second Edition, 2012 ) Eosinophilia, thrombocytopenia, lymphopenia [pathologyoutlines.com]

Phlebotomus Fever

Infected individuals developed a marked leukopenia characterized by an initial lymphopenia followed by protracted neutropenia. [ncbi.nlm.nih.gov]

COVID-19

In 63% of the patients, lymphopenia was observed. Abnormal findings on chest CTs were observed for all 41 patients. [contagionlive.com]

[…] non-specific: fever myalgia malaise non-productive cough pleuritic pain dyspnea Laboratory tests The most common findings in a study of 138 hospitalized patients were 13: lymphopenia [radiopaedia.org]

She was tachypneic (30bpm), with lymphopenia and low oxygen saturation (SpO2 85%). [radiologyassistant.nl]

Middle East Respiratory Syndrome

All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine [ncbi.nlm.nih.gov]

Laboratory analyses showed raised concentrations of lactate dehydrogenase (23 [49%]) and aspartate aminotransferase (seven [15%]) and thrombocytopenia (17 [36%]) and lymphopenia [ncbi.nlm.nih.gov]

Acquired Immunodeficiency Syndrome

Lymphopenia was not common, as it is in adult patients. [nejm.org]

He was hospitalized again in April with fever, splenomegaly, anemia, and lymphopenia. [cdc.gov]

In addition to a complete blood count (CBC), which will show lymphopenia in virtually all patients, an extensive biochemical panel is necessary to evaluate organ status - [symptoma.com]

Disseminated Histoplasmosis

[…] protein - 40 mg/L (normal [7] based on malar rash, photosensitivity, nonerosive arthritis, positive ANA, serositis (pleural effusion), and hematological disorder (leukopenia, lymphopenia [e-ijd.org]

Chronic Eosinophilic Leukemia

As expected, all patients developed lymphopenia during treatment with alemtuzumab. [clincancerres.aacrjournals.org]

Tonsillitis

Tonsillitis is an infectious disease characterized by inflammation of the tonsils in the throat region. It is caused either due to viral or bacterial infection. Children with tonsillitis have swollen tonsils that turn red accompanied by fever and inability to swallow food due to sore and painful throat. Affected individuals[…] [symptoma.com]

Intestinal Lymphangiectasia

[…] lymphangiectasia (Waldmann's disease) is an exudative enteropathy characterized by lymph leakage into the small bowel lumen leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia [ncbi.nlm.nih.gov]

The objective of this study was to better characterize the lymphopenia of PIL-confirmed patients. [ncbi.nlm.nih.gov]

[…] rare disorder characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia [ncbi.nlm.nih.gov]

Acute Sarcoidosis

↑ IgG (approx. 50% of patients) ↑ Angiotensin-converting enzyme (ACE) blood levels; may be used to monitor disease activity and therapy ↑ Inflammatory markers, possible lymphopenia [amboss.com]

Lymphopenia

lymphopenia in 10%. [doi.org]

Lymphopenia (Lymphocytopenia) Rate this post Lymphopenia Definition Lymphopenia or lymphocytopenia is a condition that involves a decrease in the level of serum lymphocytes [healthosphere.com]

There is surprisingly little literature on lymphopenia in SLE, despite its common occurrence in this disorder. 24, 25, 45, 46 Lymphopenia is well known to predispose to infections [doi.org]

Idiopathic CD4 Lymphocytopenia

I would also consider an ANA since SLE may result in lymphopenia. [aaaai.org]

It may be discovered that some of the patients diagnosed during infancy with idiopathic T-cell lymphopenia represent the earliest presentation of the idiopathic CD4-cell lymphopenia [frontiersin.org]

Causes of Lymphopenia Lymphopenia can be caused by many conditions, including infection and medication side effect. At times, the condition may only affect lymphocytes. [verywell.com]

Severe Combined Immunodeficiency

A full blood count revealed profound lymphopenia. The child was diagnosed with adenosine deaminase deficiency, a rare cause of severe combined immunodeficiency (SCID). [ncbi.nlm.nih.gov]

METHODS: Between May 1, 2010 and December 31, 2011, the National Taiwan University Hospital Newborn Screening Center screened all newborns for T-cell lymphopenia by measuring [ncbi.nlm.nih.gov]

Recognition of the characteristic lymphopenia of SCID can facilitate early diagnosis. [ncbi.nlm.nih.gov]

Complement Factor I Deficiency

Sclerosing cholangitis Zeta-chain-associated protein-70 (ZAP-70) deficiency ZAP70 AR CD8 lymphopenia CD4 hypoproliferation CD8 deficiency TAP1/TAP2/TAPBP AR CD8 lymphopenia [oncologynurseadvisor.com]

Decreased T Cell receptors Mild to moderate Lymphopenia. [pedemmorsels.com]

The infant's mother, a 29-year-old resident of San Francisco, is a prostitute and intravenous drug abuser with a history of oral candidiasis and mild lymphopenia. [cdc.gov]

Immunodeficiency

Lymphopenia and delayed cutaneous anergy remitted during treatment with a completely FULL TEXT [annals.org]

RBC adenosine deaminase assay Severe lymphopenia Levels are low in a specific form of SCID. [merckmanuals.com]

Improvement of the candidiasis was associated with remission of the delayed cutaneous anergy and lymphopenia. [annals.org]

Laron Syndrome with Immunodeficiency

Immunodeficiency is characterized by moderate lymphopenia which leads to recurrent infections of the skin and respiratory tract. [orpha.net]

Standard analyses do not usually show any anomalies, but moderate lymphopenia and hypergammaglobulinemia have been reported. [symptoma.com]

In patients with STAT5B deficiency, moderate lymphopenia with lack of CD3+, CD4+, and CD8+ T cells, CD4+/CD25+ regulatory T cells, γδ T cells, and NK cells has been described [symptoma.com]

Adenosine Deaminase Deficiency

She had frequent infections, lymphopenia, and recurrent hepatitis as a child but did relatively well in her second and third decades. [ncbi.nlm.nih.gov]

A three-yr-old Japanese boy was diagnosed with delayed-onset ADA deficiency because of recurrent bronchitis, bronchiectasia, and lymphopenia. [ncbi.nlm.nih.gov]

The clinical effects of ADA deficiency are manifest most dramatically in the immune system, where it leads to severe lymphopenia. [ncbi.nlm.nih.gov]

Primary Intestinal Lymphangiectasia

The objective of this study was to better characterize the lymphopenia of PIL-confirmed patients. [ncbi.nlm.nih.gov]

Purine-Nucleoside Phosphorylase Deficiency

Progressive lymphopenia, ataxia, and developmental delay led to diagnosis. Umbilical cord blood transplantation corrected the immunodeficiency. [ncbi.nlm.nih.gov]

There is severe lymphopenia with decreased absolute numbers of T and B lymphocytes. [ncbi.nlm.nih.gov]

Both showed severe lymphopenia and neurological involvement. [ncbi.nlm.nih.gov]

Severe Combined Immunodeficiency with Low T- and B-Cell Numbers

[…] clinical context to support the T-cell lymphopenia. [aacc.org]

Its clinical manifestations are growth retardation, dysmorphic features, malformations, and severe B- and T-cell lymphopenia. [moh-it.pure.elsevier.com]

CHARGE syndrome, and idiopathic T-cell lymphopenia. [aacc.org]

Immunodeficiency Type 23

We identified three unrelated children with recurrent infections, congenital leukopenia including neutropenia, B and T cell lymphopenia, and progression to bone marrow failure [f1000.com]

[…] received hematopoietic stem cell transplantation of cord blood and bone marrow from matched related donors; both had successful engraftment and correction of neutropenia and lymphopenia [f1000.com]

Good Syndrome

A complete blood count (CBC) is mandatory and should be obtained right away, with anemia, leukopenia (either granulocytopenia or lymphopenia) and/or thrombocytopenia being [symptoma.com]

Evaluation of his immune status during the terminal illness revealed hypogammaglobulinemia and lymphopenia consistent with a diagnosis of Good's syndrome (immunodeficiency [ncbi.nlm.nih.gov]

Although the cryptococcus is a recognised fungal pathogen in patients with other causes of CD4+ T cell lymphopenia, surprisingly this complication has not been reported in [ncbi.nlm.nih.gov]

Schimke Immunoosseous Dysplasia

He had recurrent lymphopenia with low CD4/CD8 ratio. However lymphopenia respond to granulocyte colony-stimulating factor (G-CSF), he died with pneumonia and sepsis. [ijp.mums.ac.ir]

We report on a 16-year-old girl with spondyloepiphyseal dysplasia, nephrotic syndrome, lymphopenia, and signs of defective cellular immunity. [ncbi.nlm.nih.gov]

Recurrent episodes of lymphopenia were documented. [docslide.com.br]

Combined Immunodeficiency due to CD3-Gamma Deficiency

[…] clinical context to support the T-cell lymphopenia. [aacc.org]

JAK3 deficiency: Lymphopenia occurs primarily from the absence or near absence of T cells (CD3+) and NK cells. [odlarmed.com]

Immunological findings are lymphopenia with the absence of T and NK cells, hypogammaglobulinemia, and normal or increased B cell count. [orpha.net]

Leukopenia

OBJECTIVE: To systematically review the available evidence to evaluate (1) the prevalence and degree of leukopenia, lymphopenia, and neutropenia in patients with systemic [ncbi.nlm.nih.gov]

Lymphopenia and GC use are known risk factors for infections in SLE patients. [consultqd.clevelandclinic.org]

Learn about the different types of leukopenia: neutropenia and lymphopenia and their causes. Leukopenia Inside your bones, there are small but productive factories. [study.com]

Protein-Losing Enteropathy

The diagnosis of lupus was established based on the presence of lymphopenia, proteinuria, ANA, and positive autoantibodies (anti-Sm, anti-DNA, and anti-Ro). [ncbi.nlm.nih.gov]

It is characterized by dilation and leakage of intestinal lymph vessels leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia. [ncbi.nlm.nih.gov]

All patients with PLE had lymphopenia compared with 25% of controls (P = .01). [ncbi.nlm.nih.gov]