Lymphopenia: Causes & Reasons

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Possible Causes for Lymphopenia

Cartilage Hair Hypoplasia

Laboratory studies will reveal transient macrocytic anemia, lymphopenia with a decreased CD4+/CD8+ T-cell count, and neutropenia. [symptoma.com]

Here, we present a case of CHH with mild skeletal changes and immunological findings associated with recurrent otitis media, neutropenia, and lymphopenia. [ncbi.nlm.nih.gov]

Sixty-two percent of the patients had had lymphopenia and 24% neutropenia. [ncbi.nlm.nih.gov]

Congenital AIDS

[…] secretion of tolerogenic cytokines Cytopenias Decreased cellular immunity and anergy Stress-induced nonspecific immune activation Infectious diseases: HIV infection T-cell lymphopenia [incodom.kr]

One of the early clues to an acquired immunodeficiency state is the development of absolute lymphopenia. [hemonc.mhmedical.com]

[…] recessive) IL-2RG(X-linked) Oral candidiasis, Pneumocystis jirovecii pneumonia, diarrhea before 6 months, failure to thrive, graft vs host disease, absent thymic shadow, lymphopenia [msdmanuals.com]

Ehrlichiosis

Clinical laboratory findings may include thrombocytopenia, lymphopenia, leucopenia, and elevated liver enzymes. [dhs.wisconsin.gov]

In this study, we compared the immune responses in two patients with mild/non fatal and severe/fatal HME who had marked lymphopenia, thrombocytopenia and elevated liver enzymes [ncbi.nlm.nih.gov]

Common laboratory abnormalities included thrombocytopenia (94%), elevated aspartate aminotransferase (90%), elevated alanine aminotransferase (74%), hypoalbuminemia (65%), lymphopenia [ncbi.nlm.nih.gov]

Childhood Hodgkin Lymphoma

The complete cell blood count may show neutrophilia or eosinophilia, lymphopenia or monocytosis, anemia or thrombocytopenia. [symptoma.com]

Angioimmunoblastic Lymphadenopathy

It is characterized by acute onset, severe constitutional symptoms, cervical or generalized lymphadenopathy, lymphopenia, and polyclonal hypergammaglobulinemia, all of which [ncbi.nlm.nih.gov]

Lymphopenia was seen in 2 patients.Â 4. Lymphocytes with azure granules which encompass T-suppressors were found to exceed normal values by a factor of 15.Â 5. [scipers.com]

( eMedicine ) Laboratory Polyclonal hypergammaglobulinemia and autoimmune hemolytic anemia ( Hsi: Hematopathology, Second Edition, 2012 ) Eosinophilia, thrombocytopenia, lymphopenia [pathologyoutlines.com]

Phlebotomus Fever

Infected individuals developed a marked leukopenia characterized by an initial lymphopenia followed by protracted neutropenia. [ncbi.nlm.nih.gov]

Middle East Respiratory Syndrome

All 3 patients had fever, cough, shortness of breath, bilateral infiltrates on chest x-ray, thrombocytopenia, lymphopenia and rises in serum creatinine kinase and alanine [ncbi.nlm.nih.gov]

Laboratory analyses showed raised concentrations of lactate dehydrogenase (23 [49%]) and aspartate aminotransferase (seven [15%]) and thrombocytopenia (17 [36%]) and lymphopenia [ncbi.nlm.nih.gov]

COVID-19

In 63% of the patients, lymphopenia was observed. Abnormal findings on chest CTs were observed for all 41 patients. [contagionlive.com]

[…] non-specific: fever myalgia malaise non-productive cough pleuritic pain dyspnea Laboratory tests The most common findings in a study of 138 hospitalized patients were 13: lymphopenia [radiopaedia.org]

She was tachypneic (30bpm), with lymphopenia and low oxygen saturation (SpO2 85%). [radiologyassistant.nl]

Acquired Immunodeficiency Syndrome

Lymphopenia was not common, as it is in adult patients. [nejm.org]

He was hospitalized again in April with fever, splenomegaly, anemia, and lymphopenia. [cdc.gov]

In addition to a complete blood count (CBC), which will show lymphopenia in virtually all patients, an extensive biochemical panel is necessary to evaluate organ status - [symptoma.com]

Disseminated Histoplasmosis

[…] protein - 40 mg/L (normal [7] based on malar rash, photosensitivity, nonerosive arthritis, positive ANA, serositis (pleural effusion), and hematological disorder (leukopenia, lymphopenia [e-ijd.org]

Chronic Eosinophilic Leukemia

As expected, all patients developed lymphopenia during treatment with alemtuzumab. [clincancerres.aacrjournals.org]

Tonsillitis

Tonsillitis is an infectious disease characterized by inflammation of the tonsils in the throat region. It is caused either due to viral or bacterial infection. Children with tonsillitis have swollen tonsils that turn red accompanied by fever and inability to swallow food due to sore and painful throat. Affected individuals[…] [symptoma.com]

Intestinal Lymphangiectasia

[…] lymphangiectasia (Waldmann's disease) is an exudative enteropathy characterized by lymph leakage into the small bowel lumen leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia [ncbi.nlm.nih.gov]

The objective of this study was to better characterize the lymphopenia of PIL-confirmed patients. [ncbi.nlm.nih.gov]

[…] rare disorder characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia [ncbi.nlm.nih.gov]

Acute Sarcoidosis

↑ IgG (approx. 50% of patients) ↑ Angiotensin-converting enzyme (ACE) blood levels; may be used to monitor disease activity and therapy ↑ Inflammatory markers, possible lymphopenia [amboss.com]

Primary Immune Deficiency Disorder

Laboratory investigation showed that our patient had WBC of 9500/uL, lymphopenia (ALC: 600 cells/uL) with low T cells (7 cells/uL), very low both CD4 (4 cells/uL) and CD8 [hindawi.com]

Here, the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are associated with loss-of-function of FCHO1 and impaired [nature.com]

Features of SCID • Absent tonsils • Small or absent lymph nodes • Absent thymic shadow • Lymphopenias • Decreased Number of T cells • Severe agammaglobulinemia (Swiss type [slideshare.net]

Laron Syndrome with Immunodeficiency

Immunodeficiency is characterized by moderate lymphopenia which leads to recurrent infections of the skin and respiratory tract. [orpha.net]

Standard analyses do not usually show any anomalies, but moderate lymphopenia and hypergammaglobulinemia have been reported. [symptoma.com]

In patients with STAT5B deficiency, moderate lymphopenia with lack of CD3+, CD4+, and CD8+ T cells, CD4+/CD25+ regulatory T cells, γδ T cells, and NK cells has been described [symptoma.com]

Lymphopenia

lymphopenia in 10%. [doi.org]

/diagnosis Lymphopenia/immunology* Lymphopenia/pathology Lymphopenia/physiopathology Lysophospholipids/immunology Male Middle Aged Receptors, CCR7/genetics Receptors, CCR7 [ncbi.nlm.nih.gov]

Lymphopenia (Lymphocytopenia) Rate this post Lymphopenia Definition Lymphopenia or lymphocytopenia is a condition that involves a decrease in the level of serum lymphocytes [healthosphere.com]

Idiopathic CD4 Lymphocytopenia

It may be discovered that some of the patients diagnosed during infancy with idiopathic T-cell lymphopenia represent the earliest presentation of the idiopathic CD4-cell lymphopenia [frontiersin.org]

CONCLUSIONS: We present 2 cases of idiopathic CD4 lymphopenia with no identified precipitating etiologies. [eposters.net]

A case is reported wherein a severe immunodeficiency syndrome with persistent idiopathic CD4+ lymphopenia developed in a woman suffering from systemic microscopic polyarteritis [ncbi.nlm.nih.gov]

Protein-Losing Enteropathy

The diagnosis of lupus was established based on the presence of lymphopenia, proteinuria, ANA, and positive autoantibodies (anti-Sm, anti-DNA, and anti-Ro). [ncbi.nlm.nih.gov]

It is characterized by dilation and leakage of intestinal lymph vessels leading to hypoalbuminemia, hypogammaglobulinemia and lymphopenia. [ncbi.nlm.nih.gov]

All patients with PLE had lymphopenia compared with 25% of controls (P = .01). [ncbi.nlm.nih.gov]

Leukopenia

Lymphopenia and GC use are known risk factors for infections in SLE patients. [consultqd.clevelandclinic.org]

Learn about the different types of leukopenia: neutropenia and lymphopenia and their causes. Leukopenia Inside your bones, there are small but productive factories. [study.com]

She clinically improved, and her lymphopenia also improved, despite continued use of azathioprine. [consultqd.clevelandclinic.org]

Complement Factor I Deficiency

Sclerosing cholangitis Zeta-chain-associated protein-70 (ZAP-70) deficiency ZAP70 AR CD8 lymphopenia CD4 hypoproliferation CD8 deficiency TAP1/TAP2/TAPBP AR CD8 lymphopenia [oncologynurseadvisor.com]

Decreased T Cell receptors Mild to moderate Lymphopenia. [pedemmorsels.com]

The infant's mother, a 29-year-old resident of San Francisco, is a prostitute and intravenous drug abuser with a history of oral candidiasis and mild lymphopenia. [cdc.gov]

Immunodeficiency

Lymphopenia and delayed cutaneous anergy remitted during treatment with a completely FULL TEXT [annals.org]

RBC adenosine deaminase assay Severe lymphopenia Levels are low in a specific form of SCID. [merckmanuals.com]

Improvement of the candidiasis was associated with remission of the delayed cutaneous anergy and lymphopenia. [annals.org]

Severe Combined Immunodeficiency

METHODS: Between May 1, 2010 and December 31, 2011, the National Taiwan University Hospital Newborn Screening Center screened all newborns for T-cell lymphopenia by measuring [ncbi.nlm.nih.gov]

Recognition of the characteristic lymphopenia of SCID can facilitate early diagnosis. [ncbi.nlm.nih.gov]

Newborn screening (NBS) for severe combined immunodeficiency (SCID) is now identifying infants with 22q11.2DS due to T cell lymphopenia. [ncbi.nlm.nih.gov]

Adenosine Deaminase Deficiency

She had frequent infections, lymphopenia, and recurrent hepatitis as a child but did relatively well in her second and third decades. [ncbi.nlm.nih.gov]

A three-yr-old Japanese boy was diagnosed with delayed-onset ADA deficiency because of recurrent bronchitis, bronchiectasia, and lymphopenia. [ncbi.nlm.nih.gov]

The clinical effects of ADA deficiency are manifest most dramatically in the immune system, where it leads to severe lymphopenia. [ncbi.nlm.nih.gov]

Good Syndrome

A complete blood count (CBC) is mandatory and should be obtained right away, with anemia, leukopenia (either granulocytopenia or lymphopenia) and/or thrombocytopenia being [symptoma.com]

Evaluation of his immune status during the terminal illness revealed hypogammaglobulinemia and lymphopenia consistent with a diagnosis of Good's syndrome (immunodeficiency [ncbi.nlm.nih.gov]

Although the cryptococcus is a recognised fungal pathogen in patients with other causes of CD4+ T cell lymphopenia, surprisingly this complication has not been reported in [ncbi.nlm.nih.gov]

X-Linked Severe Combined Immunodeficiency

Abstract X-linked severe combined immunodeficiency (XSCID) is a hereditary disorder characterized by severe T cell lymphopenia and abnormal B cell function. [ncbi.nlm.nih.gov]

We describe a 5-year-old boy with mild susceptibility to infection who was investigated for a mutation in IL2RG due to persistent natural killer (NK)- and T-cell lymphopenia [ncbi.nlm.nih.gov]

[…] this disorder's characteristic peripheral lymphocyte phenotype [T(-)B(+)NK(-)] was obscured by the postnatal onset of hemophagocytic syndrome that included severe B-cell lymphopenia [ncbi.nlm.nih.gov]

Congenital Chylothorax

Lymphopenia lasted for 12 d median (range 4-39 d) and was significantly correlated with the duration of lymph drainage (p = 0.001). [ncbi.nlm.nih.gov]

Congenital chylothorax: Lymphopenia and high risk of neonatal infections. Acta Paediatr 2004;93:220-4. 4. Dubin PJ, King IN, Gallagher PG. Congenital chylothorax. [jcnonweb.com]

All infants suffered from hypoalbuminaemia, electrolyte imbalances, clotting dysfunction, lymphopenia, anaemia and immune deficiency due to chronic loss of immunoglobulins [erj.ersjournals.com]

Primary Intestinal Lymphangiectasia

The objective of this study was to better characterize the lymphopenia of PIL-confirmed patients. [ncbi.nlm.nih.gov]

Severe Combined Immunodeficiency with Low T- and B-Cell Numbers

[…] clinical context to support the T-cell lymphopenia. [aacc.org]

Its clinical manifestations are growth retardation, dysmorphic features, malformations, and severe B- and T-cell lymphopenia. [moh-it.pure.elsevier.com]

CHARGE syndrome, and idiopathic T-cell lymphopenia. [aacc.org]

Purine-Nucleoside Phosphorylase Deficiency

There is severe lymphopenia with decreased absolute numbers of T and B lymphocytes. [ncbi.nlm.nih.gov]

Both showed severe lymphopenia and neurological involvement. [ncbi.nlm.nih.gov]

Lack of PNP allows intracellular accumulation of such metabolites which are particularly toxic to immature lymphoid cells, leading to lymphopenia and impaired cell-mediated [orpha.net]