Polycythemia vera is a rare chronic myeloproliferative disorder.
An increase in red cell mass is the primary feature of polycythemia vera (PV). Bone marrow analysis, however, shows a proliferation of all three myeloid lines: erythrocytes, granulocytes and platelets. The onset of polycythemia vera is often insidious.…
Gaucher disease is a lysosomal storage disease in which enzyme deficiency leads to accumulation of glycolipids in various tissues, mainly in the monocyte-macrophage system. It is transferred by autosomal recessive pattern of inheritance and depending on the subtype, patients may present with hepatosplenomegaly,…
Primary myelofibrosis is a myeloproliferative disorder induced by somatic mutations in hematopoietic stem cells. Uncontrolled proliferation of stem cells that release a variety of growth factors leads to bone marrow fibrosis and extramedullary hematopoiesis.
During initial stages of the disease, thrombocytosis accounts…
Myeloproliferative diseases are a collective group of disorders characterized by the clonal proliferation of at least one hematopoietic cell lineage. The ensuing conditions are associated with severe complications.
Myeloproliferative diseases have similar clinical pictures and generally feature nonspecific symptoms such…
Hodgkin disease (Hodgkin lymphoma) is a type of lymphoma, that is marked by the presence of Reed-Sternberg cells. The 4 subtypes of Hodgkin lymphoma are: Nodular sclerosis Hodgkin disease, Mixed cellularity Hodgkin disease, Lymphocyte-rich Hodgkin disease and Lymphocyte-depleted Hodgkin disease.
Folate-deficiency anemia frequently appears in women of childbearing age, in those who are pregnant or lactating, in alcohol abusers and malnourished individuals, thus proving the necessity of folate oral supplementation. Prevention must be carefully conducted, since the elderly may have difficulties tolerating folate…
Both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are an acute form of leukemia characterized by proliferation of early lymphoid/myeloid precursor cells which replace the normal hematopoietic cells of the bone marrow.
Patients with ALL and AML may present with symptoms related to either…
Ulcerative colitis (Colitis ulcerosa) is a form of inflammatory bowel disease. It characteristically involves the colon and extends proximally from the anal verge. The exact etiology of ulcerative colitis is unknown.
Individuals with Ulcerative Colitis can present rectal bleeding, mucous discharge from the rectum, and/or…