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46 Possible Causes for Macrocytic Anemia, Mean Corpuscular Volume Increased, Night Sweats

  • Myelodysplasia

    Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] Signs of transformation to a more aggressive lymphoma include worsening constitutional symptoms (weakness, fatigue, fever, weight loss, night sweats); rapidly enlarging lymph[iwmf.com] Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or neutropenia.[symptoma.com]

  • Primary Myelofibrosis

    Constitutional symptoms, such as night sweats, pruritus, weight loss and fever may be treated with Jakafi.[mpnresearchfoundation.org] No new therapeutic intervention was initially required; however, 2 years later, the patient reported symptomatic splenomegaly and drenching night sweats, so ruxolitinib therapy[ncbi.nlm.nih.gov] Night sweats. Weight loss. Certain factors affect prognosis (chance of recovery) and treatment options for primary myelofibrosis.[navigatingcare.com]

  • Vitamin B12 Deficiency

    Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia.[doi.org] Three cases are discussed here in which drenching night sweats were thought to be caused by vitamin B12 deficiency.[ncbi.nlm.nih.gov] Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe[ncbi.nlm.nih.gov]

  • Congenital Intrinsic Factor Deficiency

    , which may be macrocytic. 33 Congenital intrinsic factor deficiency or mutation. 34 – 36 Patients with this rare group of disorders present with megaloblastic anemia in childhood[basicmedicalkey.com] A 10-year-old male presents with abdominal swelling, night sweats, fever, and weight loss. He is diagnosed with Burkitt lymphoma.[studyblue.com] Diagnostic methods Diagnosis depends on blood tests that show low serum levels of cobalamin and megaloblastic anemia (decreased red blood cell count and increased mean corpuscular[orpha.net]

  • Acute Erythroblastic Leukemia

    : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] Almost half of people with AEL exhibit weight loss, fever and night sweats at the time of diagnosis.[en.wikipedia.org] Features associated with pernicious anemia are hemolysis with increased mean corpuscular volume (MCV), hypersegmented neutrophils, leukopenia and thrombocytopenia increased[labmedicineblog.com]

  • Autoimmune Hemolytic Anemia

    Diagnosis of AIHA is relatively easy given the constellation of laboratory findings of normocytic or macrocytic anemia, reticulocytosis, low serum haptoglobin levels, elevated[jitc.biomedcentral.com] […] and lupus are the two most commonly associated secondary causes of AIHA (albeit rare), patients may present with symptoms specific to the condition such as weight loss, night[clinicaladvisor.com] Reticulocyte counts are usually elevated, and an increased MCV (mean corpuscular volume) (greater than 100 fl) can be seen, due to the larger size of reticulocytes in comparison[cancertherapyadvisor.com]

  • Whipple Disease

    Fever and night sweats are common, as well as general weakness. There are many further possible symptoms depending on the organs affected.[encyclopedia.com] Systemic symptoms are encountered in about half of patients and consist of intermittent, mostly low-grade fever and night sweats.[prognosisapp.com]

  • Acute Myelocytic Leukemia

    Macrocytic anemia will be present unless there is an associated iron deficiency. Peripheral blood smear shows megaloblastic changes. Serum vitamin B12 levels are low.[online.epocrates.com] sweats easy bruising or petechiae (tiny red spots on the skin caused by easy bleeding) bone and joint pain belly pain (caused by the build-up of cells in organs like the[kidshealth.org] anemia, normal to increased platelet count, and increased numbers of megakaryocytes, many of which have hypolobated nuclei.[dx.doi.org]

  • Myeloproliferative Disease

    , such as macrocytic red blood cells.[doi.org] Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly.[icd9data.com] sweats Potential abdominal discomfort due to splenomegaly What does the peripheral blood look like in someone with CML?[quizlet.com]

  • Diphyllobothrium Latum Infection

    C Produces macrocytic anemia due to B12 deficiency a. Diphyllobothrium is an example of the genera under Pseudophyllidea.[gradestack.com] Review of systems was negative for fevers, night sweats, or involuntary weight loss. Physical exam was notable for an obese abdomen, but was otherwise unremarkable.[healio.com] Laboratory test results were normal except for a remarkable increase in the red blood cell count, and an evident decrease in the mean corpuscular volume and mean corpuscular[link.springer.com]

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