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143 Possible Causes for Macrocytic Anemia, Night Sweats, Splenomegaly

  • Primary Myelofibrosis

    We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Constitutional symptoms, such as night sweats, pruritus, weight loss and fever may be treated with Jakafi.[mpnresearchfoundation.org] Significant thrombopenia ( KEYWORDS: Myelofibrosis; Palliation; Splenic irradiation; Splenomegaly[ncbi.nlm.nih.gov]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] Signs of transformation to a more aggressive lymphoma include worsening constitutional symptoms (weakness, fatigue, fever, weight loss, night sweats); rapidly enlarging lymph[iwmf.com]

  • Myeloproliferative Disease

    CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] , such as macrocytic red blood cells.[doi.org] Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly.[icd9data.com]

  • Autoimmune Hemolytic Anemia

    Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[ncbi.nlm.nih.gov] Diagnosis of AIHA is relatively easy given the constellation of laboratory findings of normocytic or macrocytic anemia, reticulocytosis, low serum haptoglobin levels, elevated[jitc.biomedcentral.com] […] and lupus are the two most commonly associated secondary causes of AIHA (albeit rare), patients may present with symptoms specific to the condition such as weight loss, night[clinicaladvisor.com]

  • Chronic Myeloid Leukemia

    Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] anemia, normal to increased platelet count, and increased numbers of megakaryocytes, many of which have hypolobated nuclei.[doi.org] Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly.[icd9data.com]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Splenomegaly of more than 10 cm, basophilia and leukocytosis were associated with a shorter median survival but was not statistically significant.[ncbi.nlm.nih.gov] Case report A 71-year-old female was referred the Clinic of Hematology, in November 2007 for evaluation of the macrocytic anemia of one year duration that failed to respond[omicsonline.org] Weight loss, fever, night sweats, and reduced exercise tolerance are common complaints.[symptoma.com]

  • Acute Myelocytic Leukemia

    Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] Macrocytic anemia will be present unless there is an associated iron deficiency. Peripheral blood smear shows megaloblastic changes. Serum vitamin B12 levels are low.[online.epocrates.com] sweats easy bruising or petechiae (tiny red spots on the skin caused by easy bleeding) bone and joint pain belly pain (caused by the build-up of cells in organs like the[kidshealth.org]

  • Chronic Myelomonocytic Leukemia

    Splenomegaly is frequently seen and may be massive.[ncbi.nlm.nih.gov] At the age of 83 (t   0), he started complaining of general weakness and a blood test showed profound macrocytic anemia, with no other cytopenia (Hb   7.2 g/dL; MCV   104[ojrd.biomedcentral.com] He had no symptoms of night sweats, fever, or weight loss. Review of his medical records showed a progressively increasing leukocytosis with a peak of 58 109/L.[ncbi.nlm.nih.gov]

  • Essential Thrombocythemia

    […] essential thrombocythemia (ET) are myeloproliferative neoplasms respectively characterized by erythrocytosis and thrombocytosis; other disease features include leukocytosis, splenomegaly[ncbi.nlm.nih.gov] , may have basophils, platelets Anemia, leukocytosis, or nl platelets platelets, often abnormal Dimorphic RBC, platelets Macrocytic anemia, or nl platelets Marrow Myeloids[surgpathcriteria.stanford.edu] In one large internet-based survey of 304 patients with ET, 72% reported fatigue, and 40% or more reported itching, night sweats and bone pain.[healio.com]

  • Acute Erythroblastic Leukemia

    Typical symptoms are spongy and bleeding gums, anemia, fatigue, fever, dyspnea, moderate splenomegaly, joint and bone pain, and repeated infections.[medical-dictionary.thefreedictionary.com] : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] Almost half of people with AEL exhibit weight loss, fever and night sweats at the time of diagnosis.[en.wikipedia.org]

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