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403 Possible Causes for Macrocytic Anemia, Pancytopenia

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  • Pernicious Anemia

    Macrocytic anemia incidiously appeared in September 1999.[] The outcome was rapidly marked by febrile pancytopenia and ataxia leading to the diagnosis of pernicious anemia.[] She was readmitted with jaundice and macrocytic anemia.[]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[] […] tur·nal he·mo·glo·bi·nu·ri·a an infrequent disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia[]

  • Myelodysplasia

    Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[] An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage[] Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or neutropenia.[]

  • Severe Aplastic Anemia

    If cell size is much smaller than normal, it is known as microcytic anemia. If it is much bigger than normal, then it is macrocytic anemia.[] Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure.[] Diamond-Blackfan anemia Diamond-Blackfan anemia (DBA) is characterized by a normochromic macrocytic anemia that can be isolated, or it can be associated with growth retardation[]

  • Vitamin B12 Deficiency

    Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic[] Deficiency of vitamin B12 is a well known cause of megaloblastic anemia and pancytopenia.[] anemia.[]

  • Promyelocytic Leukemia

    The peripheral smear showed normochromic, macrocytic anemia (Hgb 9.2 g/dL, MCHC 32.8%, MCV 117 fL) and leukopenia (white blood cells [WBC] 3200/mL).[] We report a case of recurrent pancytopenia resulting from maintenance chemotherapy in a patient with acute promyelocytic leukemia and two pharmacogenetic mutations, namely[] Routine blood work showed pancytopenia and evidence of diffuse intravascular coagulation. A bone marrow biopsy confirmed the diagnosis of acute promyelocytic leukemia.[]

  • Folic Acid Deficiency

    Folic acid deficiency (FAD) may result in macrocytic anemia.[] A 79-year-old woman presented with pancytopenia (haemoglobin 3.4 mmol l-1, leucocytes 1.2.10(9)l-1, thrombocytes 22.10(9)l-1) due to folic acid deficiency.[] Severe folate deficiency can cause pancytopenia as well as megaloblastic anaemia.[]

  • Subacute Combined Degeneration of Spinal Cord

    She had macrocytic anemia (MCV 115), and vitamin B12 levels were in the low normal range—254 pg/mL (reference for low, 239).[] […] deficiency Beefy, red, smooth, and sore tongue Loss of papillae that is more pronounced along edges Hematologic manifestations of Vit B12 deficiency Megaloblastic anemia Pancytopenia[] Haematological test shows macrocytic, hypochromic anemia with pancytopenia, hypersegmented neutrophils. Mean corpuscular volume was high.[]

  • Primary Myelofibrosis

    Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia.[] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[] The clinical manifestations of PMF include splenomegaly, consequent to extramedullary hematopoiesis, pancytopenias, and an array of potentially debilitating constitutional[]

  • Systemic Mastocytosis

    anemia and thrombocytopenia.[] The disease progressed rapidly and severe pancytopenia and recurrent upper gastrointestinal bleeding became the dominant problem.[] […] organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia to more or less marked pancytopenia[]

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