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90 Possible Causes for Macrocytic Anemia, Primary Myelofibrosis

  • Myelodysplasia

    Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] primary MDS (often RAEB2 ) with fibrosis and therapy related myeloid neoplasms with fibrosis Primary Myelofibrosis, Fibrotic Phase MDS with Fibrosis Post-Polycythemia Vera[surgpathcriteria.stanford.edu] Initial stages of MDS may be characterized by macrocytic anemia with mild thrombocytopenia or neutropenia.[symptoma.com]

  • Bone Metastasis

    Abstract Bone metastases are rare in gastrointestinal stromal tumors (GISTs) and data on the clinicopathological profiles are lacking. The purpose of this report was to identify the clinicopathological profiles of this rare clinical setting by evaluating 23 cases, four of which were our own and the additional 19 were[…][ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] Alternative Names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption); Anemia - intrinsic factor; Anemia[mclaren.org] […] tur·nal he·mo·glo·bi·nu·ri·a an infrequent disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia[medical-dictionary.thefreedictionary.com]

  • Primary Myelofibrosis

    To report ocular manifestations of idiopathic primary myelofibrosis in a patient with relapsed primary myelofibrosis. Observational case report.[ncbi.nlm.nih.gov] Abstract Primary myelofibrosis terminating in megakaryoblastic crisis is uncommon. A case with this condition is reported.[ncbi.nlm.nih.gov] However, there are rare cases of primary myelofibrosis in which none of these three mutations are present (triple negative primary myelofibrosis).[merck.com]

  • Anemia

    Macrocytic anemia Possible causes of macrocytic anemia include vitamin B-12 deficiency, folate deficiency, liver disease, and hypothyroidism.[emedicine.medscape.com] Hepatosplenomegaly can indicate the presence of hemolysis, or of infiltrative processes such as lymphoma or a myelophthisic process (myelofibrosis) as a source of anemia.[cancertherapyadvisor.com] The anemia is then categorized as microcytic, macrocytic or normocytic, with or without reticulocytosis.[ncbi.nlm.nih.gov]

  • Leukoerythroblastic Anemia

    Nephropathy 2 hemolytic anemia hypochromic anemia Leukemoid Reaction macrocytic anemia Malarial Anemia microcytic anemia multiple myeloma myelodysplastic/myeloproliferative[rgd.mcw.edu] An old term, agnogenic myeloid metaplasia, indicates primary myelofibrosis with or without myeloid metaplasia.[merckmanuals.com] Initial steps in evaluating iron deficiency Hgb & HCT – Look at Hgb and HCT, that’s how you diagnose anemia MCV – This breaks it down into Microcytic, Normocytic, and Macrocytic[timeofcare.com]

  • Refractory Megaloblastic Anemia

    Examples include causesof splenomegaly, indications for splenectomy, differential diagnosis of normocytic anemia,macrocytic anemia, hypochromic anemia, thrombocytopenia, bone[books.google.de] Myelofibrosis / Myeloid metaplasia , Sideroblastic anemia-Siderochrestic, Refractory megaloblastic anemia , Secondary myelofibrosis , Thalassemia major , Thalassemia minor[wikidoc.org] TOC HEME Approach to Macrocytic /Megaloblastic Anemia By means of morphologic and biochemical criteria, macrocytic anemias can be divided into two groups: The megaloblastic[enotes.tripod.com]

  • Folic Acid Deficiency

    BACKGROUND/PURPOSE: Folic acid deficiency (FAD) may result in macrocytic anemia.[ncbi.nlm.nih.gov] FOLATE deficiency has been recognized for some time to be the cause of most cases of macrocytic anemia of pregnancy. 1 2 3 The association of megaloblastic anemia with hemorrhage[nejm.org] Pernicious anemia is a macrocytic anemia caused by vitamin B12 deficiency that is due to a lack of IF secretion by gastric mucosa.[mayomedicallaboratories.com]

  • Congenital Malabsorption of Folic Acid

    Signs and symptoms [ edit ] Affected infants present within a few months after birth with failure to thrive and severe folate deficiency manifested as macrocytic anemia and[en.wikipedia.org] Myelofibrosis / Myeloid metaplasia Opthalmologic No underlying causes Overdose / Toxicity Antimetabolite medication, Chronic alcoholism, Chemotherapy, Drug induced anemia[wikidoc.org] […] loss with normal appetite Fat Pale,voluminous,greasy offensive diarrhea Protein Edema, muscle atrophy, amenorrhea carbohydrate Abdominal bloating, flatus, w. diarrhea B12 Macrocytic[slideplayer.com]

  • Idiopathic Refractory Anemia

    Macrocytic anemia is usually caused by vitamin d eficiencies, alcohol use, medication s or thyroid.[seer.cancer.gov] Primary autoimmune myelofibrosis: definition of a distinct clinicopathologic syndrome. Am J Hematol 2003;72:8–12.[degruyter.com] Thrombocytopenia ; with impaired primary hemostasis petechial bleeding Hepatosplenomegaly (uncommon) References: [4] Diagnostics CBC with peripheral smear Normocytic or macrocytic[amboss.com]

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