Create issue ticket

321 Possible Causes for Macrocytic Anemia, Thrombocytopenia

  • Vitamin B12 Deficiency

    […] lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia and thrombocytopenia[ncbi.nlm.nih.gov] Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia.[doi.org] […] hypoproliferative megaloblastic anemia with hemolysis (hemoglobin 61g/L, mean corpuscular volume 99fL, reticulocytes 0.8%, haptoglobin undetectable), leukopenia (2.7 109/L), thrombocytopenia[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Leukopenia and Thrombocytopenia due to direct bone marrow effect, but also from cirrhosis/splenomegaly.[errolozdalga.com] Other diseases include scurvy , resulting from vitamin C deficiency; hypochromic macrocytic anemia, caused by folate deficiency, vitamin B 12 deficiency, or certain chemotherapeutic[britannica.com] In chronic alcoholism, macrocytosis, thrombocytopenia, prolonged PT, elevated GGT, hyperuricaemia or hypertriglyceridaemia may be found.[rcpa.edu.au]

  • Pernicious Anemia

    This is the second description of pernicious anemia associated with autoimmune thrombocytopenia.[ncbi.nlm.nih.gov] Macrocytic anemia incidiously appeared in September 1999.[ncbi.nlm.nih.gov] After 1 month of vitamin B12 treatment, hemoglobin and white blood cell count remain normal but thrombocytopenia persists and was considered as immunologic from SLE origin[ncbi.nlm.nih.gov]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] Non-reportable disorder s include: Anemia, leukopenia and thrombocytopenia.[seer.cancer.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    The combination of thrombosis, splenomegaly, and thrombocytopenia (TST) is challenging because anticoagulants are indicated but thrombocytopenia may increase the bleeding[ncbi.nlm.nih.gov] CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] Alternative Names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption); Anemia - intrinsic factor; Anemia[mclaren.org]

  • Folate-Deficiency Anemia

    The disease also is characterized by leukopenia (a deficiency of white blood cells, or leukocytes ), by thrombocytopenia (a deficiency of platelets ), by ineffective blood[britannica.com] Definition / general Folate deficiency is a low level of folic acid (Vitamin B9) in the body Essential features Characterized by macrocytic anemia Terminology Also called[pathologyoutlines.com] A blood smear will show macrocytes, hypersegmented polymorphs, leukopenia, and thrombocytopenia if the deficiency is severe enough.[symptoma.com]

  • Primary Myelofibrosis

    Six weeks later, he developed grade 4 thrombocytopenia and grade 3 anemia.[ncbi.nlm.nih.gov] The main adverse effects of ruxolitinib are anemia and thrombocytopenia.[merck.com] Severe side effects resulting from this therapy, such as leukocytopenia or thrombocytopenia, were never observed.[ncbi.nlm.nih.gov]

  • Congenital Malabsorption of Folic Acid

    In addition, they may have a reduction in the amount of platelets (thrombocytopenia), which can result in easy bruising and abnormal bleeding.[ghr.nlm.nih.gov] Signs and symptoms [ edit ] Affected infants present within a few months after birth with failure to thrive and severe folate deficiency manifested as macrocytic anemia and[en.wikipedia.org] Thrombocytopenia with absent radii (TAR) syndrome Excludes: Wiskott-Aldrich syndrome (279.12) 287.39 Other primary thrombocytopenia 287.4 Secondary thrombocytopenia Posttransfusion[theodora.com]

  • Acute Erythroblastic Leukemia

    Anemia and thrombocytopenia commonly occur. The central nervous system and other organs are occasionally invaded.[medical-dictionary.thefreedictionary.com] : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] Erythroleukaemia: characterised by a prominence of myeloblasts in the bone marrow, amegakaryocytic thrombocytopenia and reduced granulopoiesis, leading to neutropenia.[patient.info]

  • Severe Aplastic Anemia

    She recovered completely, but her thrombocytopenia persisted. Six weeks later she became pancytopenic. A bone marrow aspirate and biopsy showed severe aplastic anemia.[ncbi.nlm.nih.gov] Anemia most frequently causes fatigue, headaches and dizziness; thrombocytopenia provokes a tendency to bleed.[symptoma.com] Stable mixed chimerism and mild thrombocytopenia, but no active hepatitis continued. At age 13, abdominal pain was a sign of massive tumor.[ncbi.nlm.nih.gov]

Further symptoms

Similar symptoms