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530 Possible Causes for Macrocytic Anemia, Thrombocytopenia

  • Pernicious Anemia

    This is the second description of pernicious anemia associated with autoimmune thrombocytopenia.[ncbi.nlm.nih.gov] Macrocytic anemia incidiously appeared in September 1999.[ncbi.nlm.nih.gov] After 1 month of vitamin B12 treatment, hemoglobin and white blood cell count remain normal but thrombocytopenia persists and was considered as immunologic from SLE origin[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    The combination of thrombosis, splenomegaly, and thrombocytopenia (TST) is challenging because anticoagulants are indicated but thrombocytopenia may increase the bleeding[ncbi.nlm.nih.gov] CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] […] tur·nal he·mo·glo·bi·nu·ri·a an infrequent disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia[medical-dictionary.thefreedictionary.com]

  • Myelodysplasia

    Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which[ncbi.nlm.nih.gov] Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] Thrombocytopenia typically manifests as petechiae or ecchymoses; epistaxis and gum bleeding suggest severe thrombocytopenia.[emedicine.medscape.com]

  • Vitamin B12 Deficiency

    […] lactate dehydrogenase, vasoconstriction, increased platelet aggregation, and abnormal activation of the coagulation followed by microangiopathy as well as neutropenia and thrombocytopenia[ncbi.nlm.nih.gov] Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic[ncbi.nlm.nih.gov] […] hypoproliferative megaloblastic anemia with hemolysis (hemoglobin 61g/L, mean corpuscular volume 99fL, reticulocytes 0.8%, haptoglobin undetectable), leukopenia (2.7 109/L), thrombocytopenia[ncbi.nlm.nih.gov]

  • Folate-Deficiency Anemia

    Alternative Names Drug-induced thrombocytopenia; Immune thrombocytopenia - drug Causes Drug-induced thrombocytopenia occurs when certain medicines destroy platelets or interfere[mclarenhealthplan.org] Definition / general Folate deficiency is a low level of folic acid (Vitamin B9) in the body Essential features Characterized by macrocytic anemia Terminology Also called[pathologyoutlines.com] […] a form of megaloblastic (macrocytic) anemia caused by a lack of folic acid in the diet. folic acid deficiency anemia Anemia resulting from a deficiency of folic acid.[medical-dictionary.thefreedictionary.com]

  • Acute Erythroblastic Leukemia

    Anemia and thrombocytopenia commonly occur. The central nervous system and other organs are occasionally invaded.[medical-dictionary.thefreedictionary.com] : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] An excellent example was case 352 Image 1D , a 20-year-old man who had jaundice and severe macrocytic anemia.[academic.oup.com]

  • Microangiopathic Hemolytic Anemia

    In patients with cancer, systemic microvascular metastases and bone marrow involvement can cause microangiopathic hemolytic anemia and thrombocytopenia.[ncbi.nlm.nih.gov] Iron deficiency anemia is the most common nutritional disorder in the United States. macrocytic anemia anemia characterized by macrocytes (erythrocytes much larger than normal[medical-dictionary.thefreedictionary.com] Both the hemolysis and the thrombocytopenia spontaneously improved after the initiation of hemodialysis.[ncbi.nlm.nih.gov]

  • Myeloid Metaplasia

    Durable treatment responses were documented for only anemia and thrombocytopenia.[ncbi.nlm.nih.gov] Examples include causesof splenomegaly, indications for splenectomy, differential diagnosis of normocytic anemia,macrocytic anemia, hypochromic anemia, thrombocytopenia, bone[books.google.com] , Fanconi anemia , Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia Coagulation / platelets / coagulopathy[wikidoc.org]

  • Folic Acid Deficiency

    Thirteen patients with significant hemorrhage, severe thrombocytopenia, and megaloblastic bone marrows are described.[ncbi.nlm.nih.gov] Folic acid deficiency (FAD) may result in macrocytic anemia.[ncbi.nlm.nih.gov] Severe thrombocytopenia associated with acute folic acid deficiency in two inpatients is described. Both patients had severe hemorrhagic manifestations.[ncbi.nlm.nih.gov]

  • Congenital Dyserythropoietic Anemia

    A dyserythropoietic syndrome with coincidental immune thrombocytopenia seen during pregnancy is discussed.[ncbi.nlm.nih.gov] This report describes a case of congenital dyserythropoietic anemia (CDA) type I diagnosed in a 22-year-old woman with a two year history of macrocytic anemia.[ncbi.nlm.nih.gov] These results confirm the authors' previous findings and add neonatal manifestations not previously described, particularly hyperbilirubinemia and thrombocytopenia.[ncbi.nlm.nih.gov]

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