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2,302 Possible Causes for Macrocytosis, Patchy Areas of Villous Atrophy, Xeroderma

  • Tropical Sprue

    Furthermore, EME identified patchy areas of partial villous atrophy in 16 patients (5 CD and 11 TS) in whom standard endoscopy was normal.[] Neither patient was anemic, although one had hypersegmented polymorphonuclear leukocytes and both had macrocytosis and megaloblastic bone marrows.[] Macrocytosis occurs early. Serum and erythrocyte levels of folate are low. Anaemia may also be hypochromic from defective absorption of iron.[]

  • Chronic Alcoholism

    Alcohol is a common cause of macrocytosis, with a mean corpuscular volume (MCV) of 100-110 fL seen in a majority of patients.[] Alcoholism can also cause mild macrocytosis independent of folate deficiency, due to a direct effect on the bone marrow (common: 90% of alcoholics have MCV of 100-110 even[] In chronic alcoholism, macrocytosis, thrombocytopenia, prolonged PT, elevated GGT, hyperuricaemia or hypertriglyceridaemia may be found.[]

    Missing: Patchy Areas of Villous Atrophy
  • Malabsorption Syndrome

    […] cobalamin absorption with megaloblastic anemia ) Fat-soluble vitamin deficiencies Vitamins S ymp toms Causes Sources Vitamin A Night blindness Retinopathy Xerophthalmia Xeroderma[] In this setting, microcytic anaemia usually implies iron deficiency and macrocytosis can be caused by impaired folic acid or B12 absorption or both.[]

    Missing: Patchy Areas of Villous Atrophy
  • Celiac Disease

    […] as can be seen in CD can result in atypical findings on the blood smear, and patients with deficiencies of folate and vitamin B 12 may not present with the characteristic macrocytosis[]

    Missing: Patchy Areas of Villous Atrophy
  • Vitamin Deficiency

    […] erythropoiesis (formation of erythrocytes), it is important for pharmacists to note that microcytosis (low mean corpuscle volume: [MCV]) should suggest sideroblastic anemia, while macrocytosis[] This results in megaloblastic change, which causes production of larger-than-normal erythrocytes (macrocytosis).[] Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification.[]

    Missing: Patchy Areas of Villous Atrophy
  • Pellagra

    A 20-year-old woman was seen with the associated disorders of pellagra and anorexia nervosa, both of which had been present for approximately six months. Treatment with niacin induced resolution of the pellagra skin changes.[]

    Missing: Patchy Areas of Villous Atrophy
  • Multiple Myeloma

    Clinically, xeroderma pigmentosum may have similar dyspigmentation, but reveals marked photosensitivity and evidence of actinic damage beginning in infancy and early childhood[] On the other hand, several differential diagnoses of dyschromatosis may be considered: dyschromatosis universalis hereditaria, xeroderma pigmentosum, poikilodermalike amyloidosis[]

    Missing: Patchy Areas of Villous Atrophy
  • Vitamin B12 Deficiency

    We report a case of a 46-year-old Moroccan man presenting with severe hemolytic anemia, thrombocytopenia, and renal failure in absence of macrocytosis, thus mimicking a genuine[] There were no clinical or biological signs of maternal anaemia or macrocytosis. Treatment with oral vitamin B12 rapidly improved the biological findings of the child.[] Significant investigation results included a low serum vitamin B12 concentration, mild macrocytosis and raised serum homocysteine concentration.[]

    Missing: Patchy Areas of Villous Atrophy Xeroderma
  • Myxedema

    The initial workup revealed hemoglobin of 10.7 g/dl with macrocytosis (mean corpuscular volume of 103 fl), platelet count of 204 x 103/µL and white blood cell (WBC) count[]

    Missing: Patchy Areas of Villous Atrophy
  • Hereditary Orotic Aciduria

    Congenital 2 with or without Brain or Eye Anomalies via MPDZ Gene Sequencing with CNV Detection ( #12013 ) Pediatric Cancer Sequencing Panel with CNV Detection ( #7973 ) Xeroderma[] In most surveys, the most common cause of macrocytosis is megaloblastic anemia.[] .- ) orotaciduric anemia ( D53.0 ) progeria ( E34.8 ) Werner's syndrome ( E34.8 ) xeroderma pigmentosum ( Q82.1 ) Aciduria orotic (congenital) (hereditary) (pyrimidine deficiency[]

    Missing: Patchy Areas of Villous Atrophy

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