Macroglossia Causes & Reasons

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Macroglossia Symptom Checker: Possible causes include Duchenne Muscular Dystrophy. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Macroglossia,

Negated

None

Unsure

None

Possible Causes

Duchenne Muscular Dystrophy

This article describes the complex orthodontic treatment of a 22-year-old patient with Duchenne muscular dystrophy and macroglossia. [ncbi.nlm.nih.gov]

There is pseudohypertrophy of tongue (macroglossia in 30% cases) and calf muscles (60% cases). [symptoma.com]

[…] tendo Achillis reflex remains intact even in the later stages of this disease), pain in the calves with activity ( 30% of patients), pseudohypertrophy of the calf (60%), and macroglossia [emedicine.medscape.com]

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Angioedema

Infection (e.g. deep neck space infection) Foreign body Superior vena cava syndrome Macroglossia (e.g. due to acromegaly, amyloid, or hypothyroidism) Functional or factitious [emcrit.org]

Gilbert Triplett, Massive Macroglossia Secondary to Angioedema: A Review and Presentation of a Case, Journal of Oral and Maxillofacial Surgery, 73, 5, (905), (2015). [doi.org]

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Fabry Disease

We report the case of a 50-year-old male FD patient on hemodialysis who presented with macroglossia-related speaking difficulty and gastrointestinal symptoms. [ncbi.nlm.nih.gov]

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Multiple Myeloma

The aim of this report is to describe a clinical case of an elderly patient with dysphagia related to macroglossia and enlargement caused by primary amyloidosis associated [ncbi.nlm.nih.gov]

We report the case of a 50-year-old male FD patient on hemodialysis who presented with macroglossia-related speaking difficulty and gastrointestinal symptoms. [ncbi.nlm.nih.gov]

Macroglossia may occur secondary to amyloid deposition in the tongue and is a common finding in patients with amyloidosis (see the image below). [emedicine.medscape.com]

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Amyloidosis

The patient then received oral melphalan therapy and surgical intervention for macroglossia. [ncbi.nlm.nih.gov]

The aim of this report is to describe a clinical case of an elderly patient with dysphagia related to macroglossia and enlargement caused by primary amyloidosis associated [ncbi.nlm.nih.gov]

The presentation is protean, including macroglossia, a dilated and atonic esophagus, gastric polyps or enlarged folds, and luminal narrowing or ulceration of the colon. [ncbi.nlm.nih.gov]

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Mucopolysaccharidosis

MPS II and VI patients showed a more pronounced macroglossia and all type I patients showed only slight macroglossia (Graphic 2). [arquivosdeorl.org.br]

However, access to secure the airway and for conventional surgery can be challenging, due to limited neck extension, macroglossia and reduced mouth opening. [ncbi.nlm.nih.gov]

[…] hydrocephalus), heart valve abnormalities, distinctive-looking facial features that are described as "coarse," an enlarged liver and spleen (hepatosplenomegaly), and a large tongue (macroglossia [youtube.com]

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Systemic Amyloidosis

Macroglossia was present in all three cases. Diagnosis was confirmed in all three cases by biopsy using haematoxylin and eosin staining and Congo red staining. [ncbi.nlm.nih.gov]

Instead of macroglossia or diffuse papular lesions on tongue, there is a localized nodulo-ulcerative lesion, and mimicking squamous cell carcinoma. [e-ijd.org]

Correspondingly, we have observed a high number of patients with typical symptoms of AL amyloidosis (macroglossia and periorbital bleeding in 41% of AL amyloidosis patients [doi.org]

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Mucopolysaccharidosis Type 2

Common signs and symptoms include a large head, full lips, large rounded cheeks, a broad nose, hoarse voice and an enlarged tongue (macroglossia). [symptoma.com]

An enlarged tongue (macroglossia) and narrowing of the trachea results in upper respiratory infections and sleep apnea. [transparencymarketresearch.com]

Physical findings: • Coarse facial features; • Narrowing of the cervical spinal canal (spinal stenosis); • Enlarged tongue (macroglossia) and vocal cords; • Enlarged liver [secure.ssa.gov]

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Myxedema

Macroglossia is classified as true macroglossia, which exhibits abnormal histology with clinical findings, and relative macroglossia, in which normal histology does not correlate [ncbi.nlm.nih.gov]

[…] care -If thyroid labs don’t come back in timely fashion, proceed with thyroid replacement -CK is often elevated -Potentially challenging intubation: oropharyngeal edema, macroglossia [emdocs.net]

Surgery Trauma Physical Findings Physical findings in myxedema coma ( Table 2 ) may include the classic myxedematous face, which is characterized by generalized puffiness, macroglossia [aafp.org]

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Tongue Amyloidosis

0 comments, 0 ratings Abstract: Amyloidosis (AL) is a well recognized cause of macroglossia. [dental-update.co.uk]

Discussion: While macroglossia is thought to be pathognomonic of AL amyloidosis, we report a case of macroglossia with fibrillar ATTR amyloid deposits diagnosed by immuno-electron [bloodjournal.org]

Macroglossia means an enlarged tongue. It may be absolute (greater than the 95 th centile) or relative (enlarged compared with oral cavity). [radiopaedia.org]

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Tongue Carcinoma

PURPOSE: To evaluate the results of high-dose-rate (HDR)-interstitial brachytherapy (ISBT) in oral tongue carcinomas. METHODS AND MATERIALS: Between September 1999 and August 2007, 50 patients were treated for oral tongue carcinoma with HDR-ISBT. The patient's mean age was 58 years. Forty-two patients were in[…] [ncbi.nlm.nih.gov]

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Lymphoma

Most people with lymphoma first notice enlarged lymph nodes in their neck, armpits or groin. They also may have a fever, weight loss, and other vague symptoms that can mimic other diseases. Your doctor may suspect lymphoma based on the symptoms you have or from scans of affected parts of your body. Biopsy Is a[…] [lymphoma.about.com]

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Hemangioma

Hemangioma is an abnormal buildup of vascular structures on the cutaneous surface or the internal organs. These lesions are elevated, reddish, and hyperplastic and appear within the first month of life in almost a third of all cases. The majority of these lesions spontaneously resolves or involutes with time,[…] [symptoma.com]

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Lymphangioma

Key words :Cystic hygroma, Lymphangioma, Macroglossia Lymphangioma is a benign, harmatomatous tumour of lymphatic vessels with a marked predilection for the head and neck [arabmedmag.com]

Macroglossia. [ncbi.nlm.nih.gov]

Jian XC (2005) Surgical Management of Lymphangiomatous or Lymphangiohemangiomatous Macroglossia. J Oral Maxillofac Surg 63: 15-19. [omicsonline.org]

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Acromegaly

Inspection of the soft tissue revealed only macroglossia, although external palpation indicated a subcutaneous stiffness of the submandibular area. [ncbi.nlm.nih.gov]

She was observed to have macroglossia, thickened coarse skin, acral enlargement, and newly detected, uncontrolled diabetes. A diagnosis of acromegaly was suspected. [ncbi.nlm.nih.gov]

Results in general somatic hypertrophy seen as enlarged body organs, for example, macroglossia, acromegalic heart, large kidneys, and bulky skeletal muscles. [ncbi.nlm.nih.gov]

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Juvenile Myxedema

There is dwarfism, macroglossia and mental dullness. iatrogenic hypothyroidism may follow treatment for hyperparathyroidism in cats. juvenile hypothyroidism congenital hypothyroidism [medical-dictionary.thefreedictionary.com]

[…] frequency of crying Constipation Signs Large fontanelles Myxoedema - with coarse features and a large head and oedema of the genitalia and extremities Nasal obstruction Macroglossia [patient.info]

ORAL MANIFESTATIONS Symptoms  Teeth  Jaw bone  Palate  Macroglossia  Lips Radiological features  Skull changes  Air sinuses  Teeth  Jaw bone 11.    Surgery- trans [slideshare.net]

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Glycogen Storage Disease Type 2

Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and [genedx.com]

The presentation may include one or a few of the following: muscle weakness/hypotonia motor delay hypertrophic cardiomyopathy hepatomegaly macroglossia failure to thrive respiratory [radiopaedia.org]

Patients have also organomegaly (hepatomegaly, splenomegaly, macroglossia) and feeding difficulties. [ncbi.nlm.nih.gov]

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Mucopolysaccharidosis Type 6

[rarediseases.org] Jaw & Teeth Macroglossia ., ,, ,, Source MeSH Alveolar Process Child Consanguinity Dentigerous Cyst Gingival Hyperplasia Humans Macroglossia Male Mouth [symptoma.com]

The features of MPS VI include macrocephaly, hydrocephalus and macroglossia. [ivami.com]

,, ,, Source MeSH Alveolar Process Child Consanguinity Dentigerous Cyst Gingival Hyperplasia Humans Macroglossia Male Mouth Abnormalities Mucopolysaccharidosis VI Open [unboundmedicine.com]

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Lipoid Proteinosis

Additional symptoms included beaded eyelid papules, macroglossia with yellowish papules, yellowish deposits of soft palate, papular eruption in the axillary area and tuberous [histopathology-india.net]

[…] initially, a hoarse cry in infancy due to vocal cord stiffening, this is often the first clinical feature of the disease 1,3 over time thickened white oral mucosa (causing macroglossia [radiopaedia.org]

[…] shins and upper limbs that may coalesce into thickened plaques A skin biopsy with Congo red stain helps in making the diagnosis Xanthomatosis Myxoedema hoarseness of voice, macroglossia [slideshare.net]

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Neurofibromatosis Type 1

[…] because of a grossly distorted anatomy. 113 However, successful intubation after inhalation anaesthesia with sevoflurane has been described. 107 In addition, the presence of macroglossia [academic.oup.com]

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Congenital Muscular Dystrophy

Additional symptoms may occur including overgrowth (hypertrophy) of the muscles of the legs, an abnormally enlarged tongue (macroglossia), weakness and wasting (atrophy) of [rarediseases.org]

Additional features include moderate hepatomegaly and macroglossia. [ncbi.nlm.nih.gov]

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Trisomy 21

Dental malocclusion and macroglossia are associated. Technical modifications to increase macroglossia surgery safety and efficacy have been described. [doi.org]

In the postnatal period, characteristic phenotypical features point to the diagnosis: depressed nasal bridge epicanthic folds abundant neck skin macroglossia simian crease [radiopaedia.org]

The most common causes include macroglossia, glossoptosis, recurrent enlargement of the adenoid tonsils and enlarged lingual tonsils. [ncbi.nlm.nih.gov]

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Stickler Syndrome

Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). [malacards.org]

Pierre Robin sequence includes cleft palate, a large tongue (macroglossia), and a small lower jaw (micrognathia). What causes Stickler Syndrome? [aapos.org]

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Mucopolysaccharidosis Type 1

Developmental delays, hearing loss and macroglossia contribute to severely reduced language acquisition. [symptoma.com]

MPS II and VI patients showed a more pronounced macroglossia and all type I patients showed only slight macroglossia (Graphic 2). [arquivosdeorl.org.br]

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Glossitis

Type 2 Excludes erythroplakia ( K13.29 ) focal epithelial hyperplasia ( K13.29 ) leukedema of tongue ( K13.29 ) leukoplakia of tongue ( K13.21 ) hairy leukoplakia ( K13.3 ) macroglossia [icd10data.com]

Macroglossia is an abnormal enlargement of the tongue compared with the mouth and jaws. [aafp.org]

Examination often reveals a scalloping appearance on the lateral margins of the tongue caused by crowding against the teeth. 2 Macroglossia is associated with Down syndrome [aafp.org]

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Glycogen Storage Disease

Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and [genedx.com]

Macroglossia is a feature of Pompe disease and can cause airway difficulties. [ceaccp.oxfordjournals.org]

Infancy, childhood, or adulthood; residual enzyme activity in child and adult forms Clinical features: In infantile form, cardiomyopathy with heart failure, severe hypotonia, macroglossia [msdmanuals.com]

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Congenital Hypothyroidism

Coarse facies, macroglossia, constipation, and short trunk may become evident either during or beyond the neonatal period. [currentpediatrics.com]

[…] features include decreased activity and increased sleep, feeding difficulty and constipation, prolonged jaundice, myxedematous facies, large fontanels (especially posterior), macroglossia [orpha.net]

The most common presentation includes cold or mottled skin, macroglossia or umbilical hernia seen at the initial examination. [symptoma.com]

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Tongue Disease

Macroglossia, etc. [med-college.de]

Hypoglossia - congenitally short tongue Microglossia Macroglossia - an abnormally large tongue, seen in some disorders such as Down syndrome (although macroglossia can be [en.wikipedia.org]

Macroglossia describes abnormal tongue enlargement. This condition can cause misalignment of the teeth and speech difficulties. [livestrong.com]

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Sporadic Goitrous Cretinism

Cretinism  Fetal or infantile hypothyroidism  Endemic and sporadic  Sporadic –agenesis ,dyshormonogenesis  Hoarse cry, macroglossia, umbilical hernia  Immediate diagnosis [slideshare.net]

Macroglossia may be due to tumor; eg, lymphangioma. The dry skin of ichthyosis may be misleading. [generalhealthtopics.com]

The physical examination may reveal failure to thrive, large anterior and post fontanelles, dry skin, jaundice (usually prolonged), mottling, umbilical hernia, macroglossia [omicsonline.org]

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Launois Syndrome

Symmetriclipomatosis of the tongue presenting as macroglossia: Report of two cases. J Craniomaxillofac Surg 1993;7:298-301. [dryoho.com]

Structural factors related to retroglossal obstruction include macroglossia and tumor. [emedicine.medscape.com]

Like hypothyroidism, acromegaly is associated with macroglossia and increased soft tissue mass in the pharyngeal region and thus with an increased risk of SDB. [emedicine.medscape.com]

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