Macroglossia: Causes & Reasons

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Possible Causes for Macroglossia

Amyloidosis

The patient then received oral melphalan therapy and surgical intervention for macroglossia. [ncbi.nlm.nih.gov]

The aim of this report is to describe a clinical case of an elderly patient with dysphagia related to macroglossia and enlargement caused by primary amyloidosis associated [ncbi.nlm.nih.gov]

The presentation is protean, including macroglossia, a dilated and atonic esophagus, gastric polyps or enlarged folds, and luminal narrowing or ulceration of the colon. [ncbi.nlm.nih.gov]

Systemic Amyloidosis

Macroglossia was present in all three cases. Diagnosis was confirmed in all three cases by biopsy using haematoxylin and eosin staining and Congo red staining. [ncbi.nlm.nih.gov]

Amyloidosis is the commonest cause of macroglossia in adults. [3] Macroglossia if severe might lead to dysphagia. [ijdvl.com]

Instead of macroglossia or diffuse papular lesions on tongue, there is a localized nodulo-ulcerative lesion, and mimicking squamous cell carcinoma. [e-ijd.org]

Mucopolysaccharidosis Type 2

Common signs and symptoms include a large head, full lips, large rounded cheeks, a broad nose, hoarse voice and an enlarged tongue (macroglossia). [symptoma.com]

An enlarged tongue (macroglossia) and narrowing of the trachea results in upper respiratory infections and sleep apnea. [transparencymarketresearch.com]

Signs and symptoms of MPS 2A include: Macrocephaly Coarse facies Large rounded cheeks Thick lips Hypertrophic adenoids and tonsils Macroglossia Hoarse voice Short neck Retinal [symptoma.com]

Tongue Amyloidosis

0 comments, 0 ratings Abstract: Amyloidosis (AL) is a well recognized cause of macroglossia. [dental-update.co.uk]

Discussion: While macroglossia is thought to be pathognomonic of AL amyloidosis, we report a case of macroglossia with fibrillar ATTR amyloid deposits diagnosed by immuno-electron [bloodjournal.org]

Macroglossia means an enlarged tongue. It may be absolute (greater than the 95 th centile) or relative (enlarged compared with oral cavity). [radiopaedia.org]

Myxedema

Macroglossia is classified as true macroglossia, which exhibits abnormal histology with clinical findings, and relative macroglossia, in which normal histology does not correlate [ncbi.nlm.nih.gov]

[…] and hypercapnia RENAL: bladder atony, urinary retention, urinary Na+ normal or high ELECTROLYTES: hyponatraemia from increased H2O reabsorption from high levels of ADH GI: macroglossia [lifeinthefastlane.com]

[…] care -If thyroid labs don’t come back in timely fashion, proceed with thyroid replacement -CK is often elevated -Potentially challenging intubation: oropharyngeal edema, macroglossia [emdocs.net]

Acromegaly

Inspection of the soft tissue revealed only macroglossia, although external palpation indicated a subcutaneous stiffness of the submandibular area. [ncbi.nlm.nih.gov]

She was observed to have macroglossia, thickened coarse skin, acral enlargement, and newly detected, uncontrolled diabetes. A diagnosis of acromegaly was suspected. [ncbi.nlm.nih.gov]

Results in general somatic hypertrophy seen as enlarged body organs, for example, macroglossia, acromegalic heart, large kidneys, and bulky skeletal muscles. [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 6

[rarediseases.org] Jaw & Teeth Macroglossia ., ,, ,, Source MeSH Alveolar Process Child Consanguinity Dentigerous Cyst Gingival Hyperplasia Humans Macroglossia Male Mouth [symptoma.com]

Department of Pedondontics, Ege University, Bornova, Izmir, Turkey., ,, ,, Source MeSH Alveolar Process Child Consanguinity Dentigerous Cyst Gingival Hyperplasia Humans Macroglossia [unboundmedicine.com]

The features of MPS VI include macrocephaly, hydrocephalus and macroglossia. [ivami.com]

Mucopolysaccharidosis Type 1

MPS II and VI patients showed a more pronounced macroglossia and all type I patients showed only slight macroglossia (Graphic 2). [arquivosdeorl.org.br]

Developmental delays, hearing loss and macroglossia contribute to severely reduced language acquisition. [symptoma.com]

Comparison of the macroglossia degree in MPS I, II, VI. Figure 1. [arquivosdeorl.org.br]

Beckwith-Wiedemann Syndrome

Cold surgical techniques are commonly used in treating macroglossia. [ncbi.nlm.nih.gov]

Macroglossia, a large tongue, is a very common (>90%) and prominent feature of BWS. [en.wikipedia.org]

Its most common feature is macroglossia, being present in most cases. Clinically macroglossia can compromise the airway, cause dysphagia, drooling and poor cosmesis. [ncbi.nlm.nih.gov]

Alpha-Mannosidosis

Clinical findings Macrocephaly, thickened calvaria, coarse face, macroglossia, wide-spaced teeth, prognathism, deafness, mental retardation, hepatosplenomegaly. [medical-dictionary.thefreedictionary.com]

The facial trait include large head with prominent forehead, rounded eyebrows, flattened nasal bridge, macroglossia, widely spaced teeth, and prognathism. [ncbi.nlm.nih.gov]

The facial dysmorphism is marked by a large head with a prominent forehead, rounded eyebrows, a flattened nasal bridge, macroglossia, widely spaced teeth, and prognathism. [orpha.net]

Congenital Hypothyroidism

Coarse facies, macroglossia, constipation, and short trunk may become evident either during or beyond the neonatal period. [currentpediatrics.com]

There is dwarfism, macroglossia and mental dullness. iatrogenic hypothyroidism may follow treatment for hyperparathyroidism in cats. juvenile hypothyroidism congenital hypothyroidism [medical-dictionary.thefreedictionary.com]

[…] features include decreased activity and increased sleep, feeding difficulty and constipation, prolonged jaundice, myxedematous facies, large fontanels (especially posterior), macroglossia [orpha.net]

Mucopolysaccharidosis

MPS II and VI patients showed a more pronounced macroglossia and all type I patients showed only slight macroglossia (Graphic 2). [arquivosdeorl.org.br]

However, access to secure the airway and for conventional surgery can be challenging, due to limited neck extension, macroglossia and reduced mouth opening. [ncbi.nlm.nih.gov]

[…] hydrocephalus), heart valve abnormalities, distinctive-looking facial features that are described as "coarse," an enlarged liver and spleen (hepatosplenomegaly), and a large tongue (macroglossia [youtube.com]

Pallister-Killian Syndrome

The disorder in older children and young adults is characterized by a coarse and flat facies, macroglossia prognathia, everted lower lip, and severe psychomotor retardation [ncbi.nlm.nih.gov]

Oro-dental features, such as "Pallister lip," macroglossia, delayed eruption of primary teeth, high arched-palate, prognathism, and cleft palate have been occasionally reported [ncbi.nlm.nih.gov]

CASE REPORT: A 5-year-old male patient with typical PKS characteristics (facial dimorphism, temporal alopecia, micrognathia, macroglossia, mental retardation, seizures and [scielo.br]

Pompe Disease

Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and [genedx.com]

The presentation may include one or a few of the following: muscle weakness/hypotonia motor delay hypertrophic cardiomyopathy hepatomegaly macroglossia failure to thrive respiratory [radiopaedia.org]

Patients have also organomegaly (hepatomegaly, splenomegaly, macroglossia) and feeding difficulties. [ncbi.nlm.nih.gov]

Sporadic Goitrous Cretinism

Cretinism  Fetal or infantile hypothyroidism  Endemic and sporadic  Sporadic –agenesis ,dyshormonogenesis  Hoarse cry, macroglossia, umbilical hernia  Immediate diagnosis [slideshare.net]

Macroglossia may be due to tumor; eg, lymphangioma. The dry skin of ichthyosis may be misleading. [generalhealthtopics.com]

The physical examination may reveal failure to thrive, large anterior and post fontanelles, dry skin, jaundice (usually prolonged), mottling, umbilical hernia, macroglossia [omicsonline.org]

Transient Neonatal Hypothyroidism

and umbilical hernia Close up of face, showing myxedematous facies, macroglossia, and skin mottling Close up showing abdominal distension and umbilical hernia. [en.wikipedia.org]

[…] frequency of crying Constipation Signs Large fontanelles Myxoedema - with coarse features and a large head and oedema of the genitalia and extremities Nasal obstruction Macroglossia [patient.info]

[…] development moderately to severely and may be accompanied by low muscle tone, sensorineural hearing loss, prolonged hyperbilirubinemia, umbilical hernia, respiratory distress, macroglossia [msdmanuals.com]

Aspartylglucosaminuria

After the age of 6 years she had developed progressive mental deterioration, coarse facies and macroglossia with a scrotal appearance. [ncbi.nlm.nih.gov]

Features of AGU include progressive intellectual disability, characteristic facial features and body structure (i.e. microcephaly, coarse facies, low nasal bridge, macroglossia [egl-eurofins.com]

To our knowledge, macroglossia with a scrotal appearance and polycystic ovarian disease have not been reported in previous cases of AGU. [ncbi.nlm.nih.gov]

Fucosidosis

[…] features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA [connects.catalyst.harvard.edu]

[…] features psychomotor deterioration, muscle spasticity, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, seizures, recurrent infections, and macroglossia [icd10data.com]

Mucopolysaccharidosis Type 1 H/S

Intraoral examination revealed macroglossia, high-arched palate, anterior open bite and decayed 11, 12, 21, 16, 26, 36 and 46 (FDI notation). [contempclindent.org]

DS, HS α-L-Iduronidase MPS I H/S Hurler-Scheie syndrome Intermediate phenotype, macrocephaly, macroglossia, joint limitations. [hindawi.com]

Juvenile Myxedema

ORAL MANIFESTATIONS Symptoms  Teeth  Jaw bone  Palate  Macroglossia  Lips Radiological features  Skull changes  Air sinuses  Teeth  Jaw bone 11.    Surgery- trans [slideshare.net]

Lipoid Proteinosis

Additional symptoms included beaded eyelid papules, macroglossia with yellowish papules, yellowish deposits of soft palate, papular eruption in the axillary area and tuberous [histopathology-india.net]

[…] initially, a hoarse cry in infancy due to vocal cord stiffening, this is often the first clinical feature of the disease 1,3 over time thickened white oral mucosa (causing macroglossia [radiopaedia.org]

[…] shins and upper limbs that may coalesce into thickened plaques +A skin biopsy with Congo red stain helps in making the diagnosis Xanthomatosis Myxoedema hoarseness of voice, macroglossia [slideshare.net]

Launois Syndrome

Rapid linear growth, tall stature, large hands and feet, coarsening of facial features, prognathism, macroglossia, widely spaced teeth, and husky voice. [accessanesthesiology.mhmedical.com]

Symmetriclipomatosis of the tongue presenting as macroglossia: Report of two cases. J Craniomaxillofac Surg 1993;7:298-301. [dryoho.com]

Structural factors related to retroglossal obstruction include macroglossia and tumor. [emedicine.medscape.com]

Lymphangioma

Key words :Cystic hygroma, Lymphangioma, Macroglossia Lymphangioma is a benign, harmatomatous tumour of lymphatic vessels with a marked predilection for the head and neck [arabmedmag.com]

Macroglossia. [ncbi.nlm.nih.gov]

Oral lymphangiomas occur more commonly in the anterior two-third of the tongue, resulting in macroglossia. [jofs.in]

Stickler Syndrome

Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). [malacards.org]

Pierre Robin sequence includes cleft palate, a large tongue (macroglossia), and a small lower jaw (micrognathia). What causes Stickler Syndrome? [aapos.org]

Glossitis

Type 2 Excludes erythroplakia ( K13.29 ) focal epithelial hyperplasia ( K13.29 ) leukedema of tongue ( K13.29 ) leukoplakia of tongue ( K13.21 ) hairy leukoplakia ( K13.3 ) macroglossia [icd10data.com]

Macroglossia is an abnormal enlargement of the tongue compared with the mouth and jaws. [aafp.org]

Examination often reveals a scalloping appearance on the lateral margins of the tongue caused by crowding against the teeth. 2 Macroglossia is associated with Down syndrome [aafp.org]

Bamforth Syndrome

[…] at birth with cleft palate, spiky hair and thyroid dysgenesis (in most cases athyreosis) leading to congenital hypothyroidism that manifests with lethargy, poor feeding, macroglossia [rarediseases.info.nih.gov]

Multiple Myeloma

The aim of this report is to describe a clinical case of an elderly patient with dysphagia related to macroglossia and enlargement caused by primary amyloidosis associated [ncbi.nlm.nih.gov]

We report the case of a 50-year-old male FD patient on hemodialysis who presented with macroglossia-related speaking difficulty and gastrointestinal symptoms. [ncbi.nlm.nih.gov]

Carpal tunnel syndrome is quite common but only rarely caused by AL amyloidosis Macroglossia: marked enlargement of the tongue because of amyloid deposits Not everyone will [myeloma.org.uk]

Glycogen Storage Disease

Macroglossia is a feature of Pompe disease and can cause airway difficulties. [ceaccp.oxfordjournals.org]

Infantile GSDII presents during the first weeks or months of life with poor feeding, failure to thrive, macroglossia, severe hypotonia, cardiomegaly, mild hepatomegaly, and [genedx.com]

Infancy, childhood, or adulthood; residual enzyme activity in child and adult forms Clinical features: In infantile form, cardiomyopathy with heart failure, severe hypotonia, macroglossia [msdmanuals.com]

Rhizomelic Syndrome Type Urbach

[…] bacterial infections Short toe Chronic diarrhea Decreased serum testosterone level Male pseudohermaphroditism Umbilical hernia Abnormality of movement Hypoplasia of penis Macroglossia [mendelian.co]

[…] receptor 2); cutis gyrate, acanthosis nigricans, craniosynostosis (premature fusion Beckwith-Wiedemann syndrome AD; CDKN1C (cyclin-dependent kinase inhibitor 1c aka p57, Kip2); macroglossia [quizlet.com]

[…] familial 池田　康行 110 61 lissencephaly syndrome 泉川　良範 115 62 Lujan-Fryns syndrome 泉川　良範 117 63 lung 泉川　良範 118 64 lymphedema 泉川　良範 121 65 Machado-Joseph disease 斉藤　伸治 122 66 macroglossia [nippon-rinsho.co.jp]

Tollner-Horst-Manzke Syndrome

Macrocephaly-short stature-paraplegia syndrome Macrodactyly of the foot Macrodactyly of the hand Macroepiphyseal dysplasia with osteoporosis, wrinkled skin, and aged appearance Macroglossia [rarediseases.info.nih.gov]