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10 Possible Causes for Macroglossia, Nausea, Wide Space Between the First and Second Toe

  • Down Syndrome

    A 35-year-old female patient had visited another hospital for 1 month for abdominal discomfort, nausea, constipation, and palpable mass.[ncbi.nlm.nih.gov] Dental malocclusion and macroglossia are associated. Technical modifications to increase macroglossia surgery safety and efficacy have been described.[doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Multiple Endocrine Neoplasia Type 2B

    […] sweating Racing heartbeat (tachycardia) and palpitations (skipped heartbeats) Feelings of anxiety or feelings of extreme fright Pain in the lower chest or upper abdomen Nausea[stjude.org] Between ages 2 and 4, they develop full lips, large rounded cheeks , a broad nose , and an enlarged tongue ( macroglossia ).[ghr.nlm.nih.gov] Figure 3 The first toe is longer than the others and there is a wide space between the first and second toe.[ijponline.biomedcentral.com]

  • Dubowitz Syndrome

    Likewise, the diarrhea and nausea can be treated with over-the-counter medications, and the hyperactivity may be treated with prescription drugs, in some cases.[wisegeek.net] […] lipodystrophy Congenital muscular dystrophy type 1A Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation Dextrocardia Peters plus syndrome Macroglossia[checkrare.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Weaver Syndrome

    Any-grade AEs reported in more than 5% of patients included nausea (20%), thrombocytopenia (19%), cough (14%), diarrhea (11%), fatigue (12%), and asthenia (10%).[targetedonc.com] Macroglossia and hypothyroidism are seldom mentioned in the literature as clinical findings associated with the syndrome.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Russell-Silver Syndrome

    These infrequent/rare side effects include the following: mild transient hypoglycemia; injection site reactions such as rashes; transient headaches, nausea and/or vomiting[magicfoundation.org] Physical findings are variable and can include abdominal wall defects, macroglossia, and hemihyperplasia.[mayomedicallaboratories.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Cutis Laxa

    CASE PRESENTATION A 50-year-old female with history of CL diagnosed in 1991, presented to emergency room with complaints of nausea, vomiting and abdominal distension.[academic.oup.com] The facies are coarse with thick lips, macroglossia and relative macrocephaly.[caribbean.scielo.org] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br]

  • Familial Congenital Nasolacrimal Duct Obstruction

    […] bleeding (1) Hepatitis (4) Hepatitis A (2) Hepatitis B (2) Hepatitis C (7) Hepatotoxicity (1) Intestinal obstruction (1) Irritable bowel syndrome (1) Lactose intolerance (1) Nausea[innovations.ahrq.gov] Macroglossia is associated with several systemic conditions.[quizlet.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org]

  • Tricho-Oculo-Dermo-Vertebral Syndrome

    Headache, blurring or dimness of vision, and sometimes dizziness or nausea may also occur. Anatomic features of the eye.[medical-dictionary.thefreedictionary.com] Published reports are scanty and apart from macroglossia [1] no other orodental features have been mentioned in the literature.[zdoc.site] space between the first and second toes, and fusion of carpal and tarsal bones.[findzebra.com]

  • Mild Dysmorphic Features

    […] reassurance Social withdrawal and increased time spent alone Symptoms of social phobia, or social anxiety, including severe blushing, sweating, shuddering, shyness, trembling or nausea[draxe.com] We report a male infant with transient neonatal diabetes mellitus ( TNDM ; MIM 601410), macroglossia , hypertelorism , umbilical hernia , inguinoscrotal hernia and onychomycosis[wikigenes.org] , fourth, and fifth fingers; feet held in eversion, prominent heels; wide space between the first and second toes; proximally placed fifth toes; hypotonia; increased skin[ssmc-tl.com]

  • MORM Syndrome

    Pregnant women developing HELLP syndrome have reported experiencing one or more of these symptoms: Headache Nausea/vomiting/indigestion with pain after eating Abdominal or[preeclampsia.org] […] less severe and present during early childhood and are characterized by the following signs and symptoms: Macrocephaly and hydrocephalus Distinctive facial features and macroglossia[centogene.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

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