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17 Possible Causes for Macroglossia, Wide Space Between the First and Second Toe

  • Down Syndrome

    Dental malocclusion and macroglossia are associated. Technical modifications to increase macroglossia surgery safety and efficacy have been described.[doi.org] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] spacing, often with a deep plantar groove between the first and second toes.[doi.org]

  • Multiple Endocrine Neoplasia Type 2B

    Between ages 2 and 4, they develop full lips, large rounded cheeks , a broad nose , and an enlarged tongue ( macroglossia ).[ghr.nlm.nih.gov] Figure 3 The first toe is longer than the others and there is a wide space between the first and second toe.[ijponline.biomedcentral.com] The first toe is longer than the others and there is a wide space between the first and second toe (Figure 3 ).[ijponline.biomedcentral.com]

  • Genee-Wiedemann Syndrome

    […] repair in neonates, endotracheal intubation for insufficient airway, and use of specialized nipples or nasogastric tube feedings to manage feeding difficulties resulting from macroglossia[checkorphan.org] He had a wide space between the first and second toe of his feet and subungual fibroma on the second and third toe of the right foot and on the third toe of the left foot.[jmg.bmj.com] On examination, there was enlarged tongue (macroglossia) with left side hemihypertrophy.[jcnonweb.com]

  • Dubowitz Syndrome

    […] lipodystrophy Congenital muscular dystrophy type 1A Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation Dextrocardia Peters plus syndrome Macroglossia[checkrare.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

  • Atelosteogenesis Type 2

    Vascular malformation is a common cause of macroglossia. Macroglossia may interfere with speech or deglutition.[oralmaxillo-facialsurgery.blogspot.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Overgrowth, including macroglossia, exophthalmos, limb hypertrophy, and visceromegaly.[musculoskeletalkey.com]

  • Russell-Silver Syndrome

    Physical findings are variable and can include abdominal wall defects, macroglossia, and hemihyperplasia.[mayomedicallaboratories.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Macroglossia, Omphalocele, adrenal cytomegaly, gigantism, and hyperplasic visceromegaly. Birth Defects. 1969;5(2):188. Google Scholar 56.[dx.doi.org]

  • Cutis Laxa

    The facies are coarse with thick lips, macroglossia and relative macrocephaly.[caribbean.scielo.org] Other reported osteoarticular features are: a wide space between the first and second toes; talipes equinovarus; metatarsus adductus; genu recurvatum or genu valgum; flat[scielo.br] Abnormal positioning of fingers and toes, including adducted thumbs, is frequent (Reisner et al. , 1971; Philip, 1978) and was observed in both of our patients.[scielo.br]

  • Weaver Syndrome

    Macroglossia and hypothyroidism are seldom mentioned in the literature as clinical findings associated with the syndrome.[ncbi.nlm.nih.gov] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] It is characterized by large birth weight, macroglossia, umbilical hernia, ear abnormalities, and hypoglycemia.[icd10data.com]

  • Seckel Syndrome

    […] familial 池田 康行 110 61 lissencephaly syndrome 泉川 良範 115 62 Lujan-Fryns syndrome 泉川 良範 117 63 lung 泉川 良範 118 64 lymphedema 泉川 良範 121 65 Machado-Joseph disease 斉藤 伸治 122 66 macroglossia[nippon-rinsho.co.jp] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov] Wide space between first and second toes Wide-spaced big toe Widely spaced 1st-2nd toes Widely spaced first and second toes Widened gap 1st-2nd toes Widened gap first and[rarediseases.info.nih.gov]

  • Familial Congenital Nasolacrimal Duct Obstruction

    Macroglossia is associated with several systemic conditions.[quizlet.com] space between first and second toes (sandal toes) clinodactyly of the fifth finger All of these are found in individuals without DS.[medicalhomeportal.org] […] hand Macrodactyly of hand, bilateral Macrodactyly of hand, unilateral Macrodactyly of toes Macrodactyly of toes, bilateral Macrodactyly of toes, unilateral Macroencephaly Macroglossia[orpha.net]

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