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310 Possible Causes for Macrosomia, Neonatal Hypoglycemia

  • Beckwith-Wiedemann Syndrome

    Its clinical features are heterogeneous, including macrosomia, macroglossia, hemihyperplasia, abdominal wall defects, neonatal hypoglycemia, and increased risk of embryonal[ncbi.nlm.nih.gov] […] syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations Beckwith–Wiedemann syndrome edit Language Label Description[wikidata.org] Hypoglycemia in newborns with BWS should be managed according to standard protocols for treating neonatal hypoglycemia.[en.wikipedia.org]

  • Maternal Diabetes Syndrome

    […] diabetes mellitus P70.3 Iatrogenic neonatal hypoglycemia P70.4 Other neonatal hypoglycemia P70.8 Other transitory disorders of carbohydrate metabolism of newborn P70.9 Transitory[icd10data.com] macrosomia Fetal macrosomia ( 90th percentile for gestational age or 4000 g in the term infant) occurs in 15-45% of diabetic pregnancies.[emedicine.medscape.com] Maternal PCOS and GDM were also associated with threefold increased odds of neonatal hypoglycemia.[excemed.org]

  • Diabetes in Pregnancy

    Neonatal hypoglycemia was significantly less and so was NICU stay of 24 hours in metformin group (P 0.01).[ncbi.nlm.nih.gov] However, women with GDM possibly exhibit greater macrosomia than obese women.[ncbi.nlm.nih.gov] Neonatal hypoglycemia occurred more in T1DM than T2DM and contributed to a higher rate of admission to neonatal intensive care for both groups.[ncbi.nlm.nih.gov]

  • Gestational Diabetes

    Main outcome measures were neonatal hypoglycemia defined as blood glucose 36 mg/dL (severe) and 47 mg/dL (mild).[ncbi.nlm.nih.gov] (GDM-M) comparing with patients without macrosomia; ii, increased in GDM-M comparing with NC-P group; iii, increased in GDM-M comparing with NC.[ncbi.nlm.nih.gov] The first one developed transient, the second persistent neonatal hypoglycemia associated with hyperinsulinemia, that needed treatment with diazoxide for 2.5 months.[ncbi.nlm.nih.gov]

  • Neonatal Hypoglycemia

    Out of the 100 neonates, 49% of the babies with hypoglycemia were under 37 weeks gestation and just over half of the neonates that had hypoglycemia were male.[en.wikipedia.org] CONCLUSION: Diabetes was protective of neonatal hypoglycemia, which may be explained by optimum maternal glucose management; nevertheless macrosomia was independently predictive[ncbi.nlm.nih.gov] Fourteen infants demonstrated growth restriction, 1 had macrosomia, and 2 had mothers with diabetes mellitus.[ncbi.nlm.nih.gov]

  • Extreme Fetal Immaturity

    hypoglycemia P704Other neonatal hypoglycemia P708Other transitory disorders of carbohydrate metabolism of newborn P709Transitory disorder of carbohydrate metabolism of newborn[cms.gov] […] in the third trimester of pregnancy.3 Usually, macrosomia is not seen in those mothers with more severe and longer-standing diabetes (e.g., Classes F and R).[pediatricweb.com] Incidence of neonatal hypoglycemia in babies identified as at risk.[acog.org]

  • Fetal Hypoxia

    Absent / Reverse End Diastolic Flow Risk to Neonate  More admissions to NICU  Increase ICH  Increase Anemia  Increase Hypoglycemia  Increase long term permanent neurological[slideshare.net] Macrosomia can be very dangerous for a baby.[abclawcenters.com] […] morbidities associated with growth restriction, including asphyxia, meconium aspiration, sepsis, hypoglycemia and malformations.[aafp.org]

  • Glyburide

    However, the incidence of neonatal hypoglycemia was higher in the glyburide group compared to the insulin group.[ncbi.nlm.nih.gov] An increase in macrosomia in the 5 mg/day group was not significant after adjusting for maternal obesity (AOR 2.16; CI 0.96-4.88).[ncbi.nlm.nih.gov] Neonatal outcomes such as hypoglycemia (4.9%, 3.6%, P 0.44), hypocalcemia (1.3%, 0.7%, P 0.48), polycythemia (1.7%, 0.7%, P 0.31), macrosomia (11.6%, 8.7%, P 0.26), congenital[ncbi.nlm.nih.gov]

  • Fetal Malnutrition

    hypoglycemia, polycythemia, feeding intolerance, and necrotizing enterocolitis in the postnatal period were significantly higher in preterm infants with fetal malnutrition[ncbi.nlm.nih.gov] BabyCenter Medical Advisory Board, "Labor complication: Big baby (macrosomia)" , BabyCenter, L.L.C. , 2006. Retrieved 5 November 2010.[en.wikipedia.org] hypoglycemia CNS dysfunction in newborn due to birth injury Pulmonary hemorrhage originating in the perinatal period Bronchopulmonary dysplasia originating in the perinatal[quizlet.com]

  • Leucine-induced Hypoglycemia

    C Leucine Causes of Persistent Neonatal Hypoglycemia (Blood glucose 4Omg/dL):- a. Hyper insulin states: - i. Beta-cell Hyper plasia (NESIDIOBLASTOSIS) ii.[gradestack.com] Mitochondrial DNA depletion syndrome, hepatocerebral form , Mitochondrial trifunctional protein deficiency , Navajo neurohepatopathy , Nephroblastomatosis-fetal ascites-macrosomia-wilms[en.wikipedia.org] Recessive mutations of these genes cause a severe form of neonatal hypoglycemia that frequently requires near-total pancreatectomy.[genome.jp]

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