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30 Possible Causes for Malaise, Polyclonal Hyperglobulinemia

  • Castleman Disease

    The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[] The patient was initially treated with antiretroviral therapy with a combination of elvitegravir, cobicistat, emtricitabine and tenofovir that improved her fatigue and malaise[] , hypoalbuminemia, polyclonal hypergammaglobulinemia, leukocytosis, thrombocytosis or splenomegaly. 1,4 In contrast to the localized form, the clinical course of the multicentric[]

  • Chronic Active Hepatitis

    hyperglobulinemia.[] A 56-year-old Saudi male was admitted with abnormal liver chemistry values and a 5-month history of lethargy, malaise, anorexia, and jaundice.[] A 27-year-old woman, para 0-1-2-1, presented at 36 weeks' gestation with a 2-week history of malaise, nausea, emesis, diarrhea, and an 18-lb weight loss.[]

  • HIV Infection

    Hyperactivation is reflected in dramatic polyclonal hyperglobulinemia, only a portion of which is directed against HIV antigens;(59) bone marrow plasmacytosis;(60) heightened[] The patient presented with acute onset of fever, cough, hemoptysis and malaise.[] Hodinka Abstract A 15-year-old previously healthy male presented with fever, vomiting, diarrhea, malaise, and altered mental status.[]

  • Chronic Active Hepatitis B

    hyperglobulinemia.[] Transient side effects of malaise and influenza like symptoms occurred in all patients and resolved rapidly after treatment.[] Snapshot A 35-year-old presents to the emergency department due to abdominal pain and malaise. He also reports "yellow-ing" of his skin.[]

  • Angioimmunoblastic Lymphadenopathy

    In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[] Angioimmunoblastic lymphadenopathy with dysproteinemia is a disorder characterized by an acute onset of generalized lymphadenopathy associated with fever, malaise, pruritus[] A woman 68 years of age had fever, malaise, diffuse lymphadenopathy, splenomegaly followed by abdominal pain, and diarrhea.[]

  • Rosai-Dorfman Disease

    hyperglobulinemia.[] Additional findings may include fever, malaise, epistaxis, night sweats, weight loss, leukocytosis, elevated erythrocyte sedimentation rate and hypergammaglobulinemia.[] Rosai-Dorfman disease is a rare benign histiocytic disorder that arises predominantly in lymph nodes with fever and malaise, but can affect various organs, with or without[]

  • IgG4-Related Retroperitoneal Fibrosis

    hyperglobulinemia.[] ., fever, malaise, weight loss, flank pain, etc.). Bilateral ureteral obstruction, with subsequent hydronephrosis and obstructive nephropathy, is common.[] Frequently associated: vomiting, nausea, anorexia, malaise, fatigue, weight loss, constipation or diarrhoea, oliguria or anuria.[]

  • Pyoderma

    Monoclonal or polyclonal hyperglobulinemia may also be associated with PG.[ 3 ] However, the immunological abnormalities associated with PG are not always consistently observed[] People commonly have fever and a general feeling of illness (malaise).[] Joint pains (arthralgias) and body malaise (body weakness) may be accompanying symptoms of this condition.[]

  • Thyroiditis

    Plasma protein electrophoresis showed polyclonal hyperglobulinemia, with normal immunofixation.[] She presented to our hospital with sudden-onset general malaise, edema, and hoarseness with an elevated thyroid-stimulating hormone (373.3 μIU/ml) level and very low triiodothyronine[] […] much less common than Hashimoto thyroiditis but most common cause of thyroid pain Painful swallowing (odynophagia), sore throat, thyroid region tenderness, fever, fatigue, malaise[]

  • Multicentric Castleman's Disease

    hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[] […] case illustrates the difficulties involved in diagnosing multicentric Castleman's disease (MCD) in a human immunodeficiency virus-infected man with febrile episodes and malaise[] The main manifestations of MCD are systemic symptoms ( i.e. high fever, malaise, weight loss), associated with generalised lymphadenopathy and hepatosplenomegaly.[]

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