and delayed puberty in affected males or females, sex hormone replacement therapy may be considered in some cases.
[rarediseases.org]
[…] cases, renal malformations, oral anomalies (high arched palate, malocclusion, impacted teeth, retroclined mandibular incisors), coagulation defects, hypogonadism.
[amhsr.org]
In addition, because deficiencies of certain hormones (gonadotrophin) may contribute to abnormally decreased function of the gonads (hypogonadism) and delayed puberty in some
[rarediseases.org]