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98 Possible Causes for Male Sterility, Midline Defects

  • Panhypopituitarism

    CONCLUSION: These data demonstrate that homozygous HESX1 mutation causing an R160H substitution can result in panhypopituitarism without midline defects.[ncbi.nlm.nih.gov] We report on a neonate with unexplained heart failure and minor physical anomalies, suggesting a midline defect. She was diagnosed with complete CPHD.[ncbi.nlm.nih.gov] Children with congenital midline defects or optic atrophy (which suggests the presence of septo-optic dysplasia) and boys with micropenis due to deficit gonadotropin hormones[symptoma.com]

  • Hypothyroidism

    defects of the brain, should alert the physician to suspect the diagnosis of septo-optic dysplasia.[doi.org] […] polyuria (from antidiuretic hormone deficiency), or small phallus in boys (from gonadotropin deficiencies), along with the presence of blindness, congenital nystagmus, or midline[doi.org]

  • Primary Male Hypogonadism

    Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[merckmanuals.com] The genetic defect is known; inheritance is classically X-linked but can also be autosomal dominant or autosomal recessive.[merckmanuals.com]

  • Hypogonadism

    Other manifestations include microphallus, cryptorchidism, midline defects, and unilateral kidney agenesis.[msdmanuals.com] […] aging male, Fertility and Sterility, 10.1016/j.fertnstert.2008.08.094, 90, 5, (S83-S87), (2008).[doi.org] The genetic defect is known; inheritance is classically X-linked but can also be autosomal dominant or autosomal recessive.[msdmanuals.com]

  • Kallmann Syndrome

    Abstract Kallmann syndrome (isolated hypogonadotropic hypogonadism) is associated with a number of midline defects, especially anosmia.[doi.org] It affects primarily males at an incidence of 1 out of 10,000 and the disease becomes apparent when they fail to begin puberty and to develop secondary sexual characteristics[prep4usmle.com] Steril. 95, 2324–2329.e1–e3 (2011). 115. Cunningham, G. R. & Toma, S. M. Clinical review: Why is androgen replacement in males controversial? J. Clin. Endocrinol.[doi.org]

  • Wolf Hirschhorn Syndrome

    Characteristics include marked prenatal and postnatal growth retardation with psychomotor delay, profound mental deficiency, distinctive facies, and midline defects.[ncbi.nlm.nih.gov] Possible dextrocardia, male sterility. Pyruvate Dehydrogenase Deficiency Autosomal Recessive.[kumc.edu] Wolf-Hirschhorn syndrome (WHS) is a well-known genetic condition characterized by typical facial anomalies, midline defects, skeletal anomalies, prenatal and postnatal growth[ncbi.nlm.nih.gov]

  • Omphalocele

    It may also be accompanied by other malformations, including multiple facial dysmorphism, midline defects, cleft lip and palate, musculoskeletal and other non-neurological[ncbi.nlm.nih.gov] An intact omphalocele was noted at birth and was wrapped in sterile gauze in a plastic bag.[healio.com] An omphalocele is a protrusion of abdominal viscera from a midline defect at the base of the umbilicus.[msdmanuals.com]

  • Melhem-Fahl Syndrome

    […] cleft of lower lip Midline defects autosomal type Midline defects recessive type Midline developmental field defects Midline field defects Midline lethal granuloma Mietens[bioreference.net] sterility due to chromosome Y Parkinsonism linked to Mediastinal endodermal sinus deletion chromosome 17 tumors Pterygium white sclerae Chronic berylliosis frontotemporal[yumpu.com] […] type Midline defects recessive type Midline developmental field defects Mievis Verellen Dumoulin syndrome Milner Khallouf Gibson syndrome Minkowski-Chauffard disease Minoxidil[mindmappedia.com]

  • Hypogonadotropic Hypogonadism 3

    Occasionally the diagnosis is made earlier due to investigation of other associated anomalies, including: midline defects cleft lip and palate renal agenesis sensorineural[radiopaedia.org] Genome-wide association study identifies candidate genes for male fertility traits in humans.Am J Hum Genet. 2012; 90(6): 950-961.[content.sciendo.com] […] producing GRH–gonadotropin-releasing hormone; FSH and LH impairs sperm and androgen production Clinical Delayed puberty, micropenis, eunuchoid features, cryptorchidism, midline[medical-dictionary.thefreedictionary.com]

  • Hypogonadotropic Hypogonadism 8

    Occasionally the diagnosis is made earlier due to investigation of other associated anomalies, including: midline defects cleft lip and palate renal agenesis sensorineural[radiopaedia.org] Fertil Steril 77:555-560, 2002. 10. Wilson DA, Hofman PL, Miles HL, Unwin KE, McGrail CE, Cutfield WS.[siicsalud.com] […] producing GRH–gonadotropin-releasing hormone; FSH and LH impairs sperm and androgen production Clinical Delayed puberty, micropenis, eunuchoid features, cryptorchidism, midline[medical-dictionary.thefreedictionary.com]

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