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10 Possible Causes for Malnutrition, Mutation in the CDK6 Gene, Personality Change

  • Malignant Gastric Neoplasm

    Most cancers are caused by gene changes that happen during a person’s lifetime, but a person’s cancer risk can be higher if they have one of these rare inherited mutations[debbiesdream.org] BACKGROUND/AIM: Recent evidence suggests that preoperative malnutrition may lead to poor survival in cancer patients.[ncbi.nlm.nih.gov] Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com]

  • Gastric Adenocarcinoma

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] According to MS-score, 92% of the patients had malnutrition and it could predict malnutrition with 96.8% sensitivity, 50% specificity and accuracy of 91.4%.[ncbi.nlm.nih.gov] In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org]

  • Glioblastoma Multiforme

    General symptoms for metastatic brain tumors include: Headaches Weakness on one side of the body Problems with balance Seizures Behavior, memory and personality changes Glioblastoma[uwhealth.org] Seizures Induced Second Neoplasm Spinal Cord Compression Infections Spondilodiscitis Leptomeningeal Diseases Surgery Related Pathology Long Term Complications Transplant Malnutrition[web.archive.org] The inherited predisposition factors in pediatric HGG are as follows: germline mutations in tumor suppressor genes TP53 and neurofibromin 1 (NF1); oncogenic NTRK fusions [[doi.org]

  • Pancreatic Neoplasm

    Psychosocial Assess for the presence of irritability, depression, and personality changes.[medical-dictionary.thefreedictionary.com] Palliation should address pain control, biliary and gastric outlet obstruction, malnutrition, thromboembolic disease, and depression.[ncbi.nlm.nih.gov] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov]

  • Biliary Carcinoma

    If you are concerned about any changes you experience, please talk with your doctor.[cancer.net] The presence of infection, severe jaundice and malnutrition also predict poor outcomes but may be corrected to an extent prior to surgery.[londonlivercentre.co.uk] This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org]

  • Rhabdomyosarcoma

    Shrieve, Demographics, stage distribution, and relative roles of surgery and radiotherapy on survival of persons with primary prostate sarcomas, Cancer Medicine, 7, 12, (6030[doi.org] The patient died from malnutrition and multiple organ failure 141 days after her initial admission.[journals.lww.com] The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov]

  • Gastric Cancer

    Because there is no one risk factor directly associated with gastric cancer, there is no strict lifestyle change that can greatly decrease a person's risk of developing gastric[oncolink.org] […] examination Identify postoperative dysfunctions, signs, symptoms, and clinical findings indicating local recurrence Evaluate nutritional status to prevent weight loss and identify malnutrition[amboss.com] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com]

  • Acute Myelomonocytic Leukemia

    CML is an acquired leukemia, resulting from a change in a person's DNA. This change results in an uncontrolled growth of white cells.[nationalcmlsociety.org] , monocytic leukemias) Complications Immediate and short-term complications include the following: Serious infections Alopecia Emesis GI erosions and bleeding Hemorrhage Malnutrition[emedicine.medscape.com] In one-third we observed chromosome abnormalities (e.g. trisomy 8, del20q) and gain or loss of genes (e.g. NF1, RB1 and CDK6 ).[bmccancer.biomedcentral.com]

  • Autosomal Dominant Microcephaly

    WNT5A Selected Pathogenic Variants DNA Nucleotide Change (Alias 1 ) Predicted Protein Change (Alias 1 ) Reference Sequences c.206G A p.Cys69Tyr NM_003392 .4 NP_003383 .2 c[ncbi.nlm.nih.gov] ., rubella, CMV, toxoplasmosis, AIDS other putative elements: hyperthermia, malnutrition, antiepileptic drugs, other drugs Others Lissencephaly, holoprosencephaly, and other[emilytam.com] […] in the ZNF335 gene ({610827}) on 20q13; MCPH11 ({615414}), caused by mutation in the PHC1 gene ({602978}) on 12p13; MCPH12 ({616080}), caused by mutation in the CDK6 gene[diseaseinfosearch.org]

  • Homozygous 11p15-p14 Deletion Syndrome

    change, affective psychosis, or schizophrenic psychosis.[quizlet.com] The p14ARF and p16INK4a genes have been implicated as tumor suppressor genes and are frequently mutated, deleted, or inactivated through promoter hypermethylation in human[hindawi.com] Treatment/Prognosis: Death from general aninition, malnutrition, and pneumonia.[quizlet.com]

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