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358 Possible Causes for Marked Clinical Heterogeneity

  • Otitis Media

    Given the large degree of heterogeneity amongst the studies (both clinical and statistical; I² 82%), we did not pool the data in a meta‐analysis.[doi.org] […] four weeks Six studies (n 1082 children) reported partial or complete resolution of OME at two to four weeks ( Healy 1984 ; Hemlin 1997 ; Mandel 1987 ; Marchisio 1998 ; Marks[doi.org] […] treatment Five studies (n 1021 children) reported partial or complete resolution of OME at end of treatment (n 1021 children) ( Healy 1984 ; Hemlin 1997 ; Mandel 1987 ; Marks[doi.org]

  • Chronic Obstructive Pulmonary Disease

    COPD is a heterogeneous condition with marked variation in progression between individuals ( Casanova 2011 ; Nishimura 2013 ).[doi.org] The initial underlying pathology of COPD is confined to the lungs, and a clinical diagnosis is based on presenting symptoms and confirmation of airflow obstruction with a[doi.org]

  • Heart Failure

    […] inter-study heterogeneity.[ncbi.nlm.nih.gov] Conclusions MRAs improve clinical outcomes in selected cohorts of older patients with HEFREF but not HEFPEF.[doi.org] MRAs improve clinical outcomes in selected cohorts of older patients with HEFREF but not HEFPEF.[ncbi.nlm.nih.gov]

  • Congestive Heart Failure

    […] inter-study heterogeneity.[ncbi.nlm.nih.gov] Conclusions MRAs improve clinical outcomes in selected cohorts of older patients with HEFREF but not HEFPEF.[doi.org] MRAs improve clinical outcomes in selected cohorts of older patients with HEFREF but not HEFPEF.[ncbi.nlm.nih.gov]

  • Stroke

    Additional challenges that face stroke scientists in the next decades include the major heterogeneity in clinical presentations/phenotypes, stroke subtypes and etiologies,[frontiersin.org] […] the complex interactions between the brain, the blood vessels and the remainder of the body, and the marked differences in access to and quality of stroke management depending[frontiersin.org]

  • Allergic Asthma

    Abstract Bronchial asthma (BA) is a chronic inflammatory disease with a marked heterogeneity in pathophysiology and etiology.[ncbi.nlm.nih.gov] […] heterogeneity of BA may be related to the inducing mechanism(s) (allergic vs non-allergic), the histopathological background (eosinophilic vs non-eosinophilic), and the clinical[ncbi.nlm.nih.gov]

  • Hashimoto Thyroiditis

    Pooling of the studies was not feasible due to marked clinical heterogeneity (I 2 99%).[cochrane.org]

  • Psoriasis

    Laura Israel and Mark Mellett, Clinical and Genetic Heterogeneity of CARD14 Mutations in Psoriatic Skin Disease, Frontiers in Immunology, 10.3389/fimmu.2018.02239, 9, (2018[doi.org] Christopher EM Griffiths and Jonathan NWN Barker, Pathogenesis and clinical features of psoriasis, The Lancet, 10.1016/S0140-6736(07)61128-3, 370, 9583, (263-271), (2007).[doi.org]

  • Parkinson's Disease Type 3

    The research team detected a marked clinical heterogeneity in both type 3 and type 1 patients.[gaucherdiseasenews.com]

  • Coronary Atherosclerosis

    Risk factor declines were modest but owing to marked unexplained heterogeneity between trials, the pooled estimates are of dubious validity.[ncbi.nlm.nih.gov] Authors' conclusions Interventions using counselling and education aimed at behaviour change do not reduce total or CHD mortality or clinical events in general populations[doi.org] Interventions using counselling and education aimed at behaviour change do not reduce total or CHD mortality or clinical events in general populations but may be effective[ncbi.nlm.nih.gov]

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