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60 Possible Causes for Massive Splenomegaly, Neutrophil Count Decreased, Pancytopenia

  • Leukemia

    Splenomegaly can be massive, consistency high, with the fibrous thickening of the capsule.[ncbi.nlm.nih.gov] […] in the incidence of infection when the neutrophil count increases from less than 0.1 10 9 /L to greater than 0.5 10 9 /L. 11 Although documented infections in HCL patients[bloodjournal.hematologylibrary.org] This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by progressive anemia, massive splenomegaly, leukoerythroblastosis, extramedullary hematopoiesis[ncbi.nlm.nih.gov]

  • Hypersplenism

    CONCLUSION: Our results demonstrate that shunt surgery with partial resection of the spleen is effective and safe for pediatric patients with massive splenomegaly and severe[ncbi.nlm.nih.gov] Immune Hemolytic Anemia White cells May be elevated due to an increased in neutrophils Counts may approach 30 X 10 9 /L Platelets Usually normal Red cells Hb and Hct decreased[5minuteconsult.com] Hypersplenism should be considered in patients with persistent or recurrent pancytopenia and splenomegaly post-transplantation.[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] : 1500/μL absolute neutrophil count, 100000/μL platelets, 11.0 g/dL hemoglobin or 50% improvement for either of these parameters without transfusions or growth factors.[clinicaltrials.gov] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] […] in the incidence of infection when the neutrophil count increases from less than 0.1 10 9 /L to greater than 0.5 10 9 /L. 11 Although documented infections in HCL patients[bloodjournal.hematologylibrary.org] During the preoperative evaluation, pancytopenia was detected.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com]

  • Visceral Leishmaniasis

    ., infection with Leishmania sp. associated with high fever, weight loss, massive splenomegaly and markedly altered laboratory parameters, is generally fatal if untreated.[ncbi.nlm.nih.gov] We present an unusual case of febrile pancytopenia in a nonagenarian who was diagnosed with visceral leishmaniasis.[ncbi.nlm.nih.gov] He had massive splenomegaly. His cardiovascular, respiratory and neurological examination were normal.[ncbi.nlm.nih.gov]

  • Secondary Myelofibrosis

    These findings are rare and myeloid metaplasia with striking extramedullary hematopoiesis causing massive splenomegaly and mimicking agnogenic myeloid metaplasia is seldom[ncbi.nlm.nih.gov] Platelet counts initially may be high, normal, or decreased; however, thrombocytopenia tends to supervene as the disorder progresses. 6. 6 MYELOFIBROSIS BY DR .MAGDI AWAD[slideshare.net] We concluded that the pancytopenia was because of bone marrow fibrosis resulting from primary hyperparathyroidism.[ncbi.nlm.nih.gov]

  • Post-Polycythemia Vera Myelofibrosis

    Our present case suggests the potential risk of TLS development after ruxolitinib treatment, particularly in patients with massive splenomegaly.[ncbi.nlm.nih.gov] Neutrophils are immature and myeloblasts may be present even in the absence of acute leukemia. Platelets may be high, normal or decreased.[clinicaladvisor.com] Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis.[duo.uio.no]

  • Leukoerythroblastic Anemia

    Massive splenomegaly can cause abdominal pressure, early satiety, cachexia, portal hypertension, and left upper quadrant abdominal pain; hepatomegaly may be present.[merckmanuals.com] THIS IS NOT A TRUE DECREASE BUT RESULTS FROM INCREASED MARGINATION BY NEUTROPHILS.[meddean.luc.edu] Myeloproliferative Disease, Autosomal Recessive Myeloproliferative Disorder, Chronic, with Eosinophilia myeloproliferative neoplasm neonatal anemia normocytic anemia pancytopenia[rgd.mcw.edu]

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