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178 Possible Causes for Massive Splenomegaly, Pancytopenia

  • Leukemia

    Splenomegaly can be massive, consistency high, with the fibrous thickening of the capsule.[ncbi.nlm.nih.gov] This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com] Prolonged pancytopenia with severe BM aplasia was seen in a further 2 patients, one of whom died from a fungal pneumonia.[doi.org]

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com] Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by progressive anemia, massive splenomegaly, leukoerythroblastosis, extramedullary hematopoiesis[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com]

  • Chronic Lymphocytic Leukemia

    splenomegaly and occasionally lymphadenopathy; prognosis is often poor.[medical-dictionary.thefreedictionary.com] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov]

  • Hypersplenism

    CONCLUSION: Our results demonstrate that shunt surgery with partial resection of the spleen is effective and safe for pediatric patients with massive splenomegaly and severe[ncbi.nlm.nih.gov] Hypersplenism should be considered in patients with persistent or recurrent pancytopenia and splenomegaly post-transplantation.[ncbi.nlm.nih.gov] Apart from a strongly positive Mantoux test, all investigations for massive splenomegaly proved negative.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.[ncbi.nlm.nih.gov] We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.[ncbi.nlm.nih.gov] During the preoperative evaluation, pancytopenia was detected.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Chronic myeloid leukemia (CML) is a chronic myeloproliferative disorder that usually presents with high white blood cell counts and massive splenomegaly.[ncbi.nlm.nih.gov] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov] Here, we report a case of aCMLin a 5-month baby who presented with massive splenomegaly. The diagnosis was in accordance with the WHO criteria established in 2008.[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[symptoma.com] Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[symptoma.com] The clinical presentation involves generalized lymphadenopathy, splenomegaly that is often massive and systemic symptoms, primarily because the vast majority of patients are[symptoma.com]

  • Myeloproliferative Disease

    Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov] ( D61.82 ) pancytopenia (due to) (with) congenital (pure) red cell aplasia ( D61.01 ) pancytopenia (due to) (with) hairy cell leukemia ( C91.4- ) pancytopenia (due to) (with[icd10data.com] ) human immunodeficiency virus disease ( B20.- ) pancytopenia (due to) (with) leukoerythroblastic anemia ( D61.82 ) pancytopenia (due to) (with) myeloproliferative disease[icd10data.com]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    […] included thrombocytopenia (n 8), diarrhea (n 3), alanine aminotransferase elevation (n 3), aspartate aminotransferase elevation (n 2), dyspnea (n 2), neutropenia (n 2), pancytopenia[bloodjournal.org]

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