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142 Possible Causes for Massive Splenomegaly, Pancytopenia, Thrombocytosis

  • Primary Myelofibrosis

    She also underwent splenectomy when she was 13 years old, due to massive splenomegaly, anemia and various infection disease episodes.[ncbi.nlm.nih.gov] Objectives: To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET).[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Myeloproliferative Disease

    Splenomegaly, sometimes massive, is a characteristic finding. Symptoms include the following: Splenic pain. Early satiety. Anemia. Bone pain. Fatigue. Fever.[northshore.org] One patient clearly represents a case of RARS with reactive thrombocytosis.[ncbi.nlm.nih.gov] Four years later, at the age of 16, her brother was diagnosed as having acute myelofibrosis, and some months afterwards he died from fulminant pneumonia coincidently with pancytopenia[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Here, we report a case of aCMLin a 5-month baby who presented with massive splenomegaly. The diagnosis was in accordance with the WHO criteria established in 2008.[ncbi.nlm.nih.gov] A 10-year-old boy presented with spontaneous bruising and was found to have extreme thrombocytosis without neutrophilia/shift to immaturity, basophilia or eosinophilia.[ncbi.nlm.nih.gov] We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation[ncbi.nlm.nih.gov]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Here we report a case of coexistence of BCR-ABL1 fusion gene and CALR mutation, diagnosed due to persistent thrombocytosis while the patient was in treatment-free, complete[sci.amegroups.com] […] included thrombocytopenia (n 8), diarrhea (n 3), alanine aminotransferase elevation (n 3), aspartate aminotransferase elevation (n 2), dyspnea (n 2), neutropenia (n 2), pancytopenia[bloodjournal.org] Leukemia With JAK2 - and BCR/ABL -Positive Mutation Case Presentation In 1999, a 68-year–old man presented with hematocrit of 50, and associated leukocytosis, erythrocytosis, thrombocytosis[gotoper.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    Extreme thrombocytosis was present, although no evidence of acquired von Willebrand disorder was found.[ncbi.nlm.nih.gov] An adolescent with chronic myeloid leukemia initially presented with extreme thrombocytosis, increased megakaryopoiesis with dysmorphic features, and focal myelofibrosis in[ncbi.nlm.nih.gov] […] related to leukostasis), gastrointestinal bleedings (related to basophilia and enhanced histamine release), spontaneous bleedings or thrombosis (due to thrombocytopenia or thrombocytosis[symptoma.com]

  • Post-Polycythemia Vera Myelofibrosis

    Our present case suggests the potential risk of TLS development after ruxolitinib treatment, particularly in patients with massive splenomegaly.[ncbi.nlm.nih.gov] BACKGROUND: The myeloproliferative neoplasms, essential thrombocytosis, polycythemia vera and primary myelofibrosis, share the same acquired genetic lesion, but the concept[ncbi.nlm.nih.gov] Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis.[duo.uio.no]

  • Leukemia

    Splenomegaly can be massive, consistency high, with the fibrous thickening of the capsule.[ncbi.nlm.nih.gov] Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis The criteria for MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T; previously[doi.org] This fact sheet discusses the theory that intermittent fasting may reduce the risk of cancer or improve outcomes with anticancer treatments. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Myelofibrosis

    "With massive splenomegaly, patients develop abdominal discomfort, early satiety and weight loss," said Gotlib.[medicalxpress.com] Thrombocytosis is more common than thrombocytopenia.[patient.info] A 68-year-old man presented to us with pancytopenia, erythroderma, and multiple lymphadenopathies.[ncbi.nlm.nih.gov]

  • Non-Hodgkin Lymphoma

    […] antibiotic therapy may result in remission of the disease.[ 97 ] Splenic marginal zone lymphoma Splenic marginal zone lymphoma is an indolent lymphoma that is marked by massive[web.archive.org] In the first case, the laboratory tests showed anemia, thrombocytosis, elevated inflammatory biomarkers, a low level of iron, and hypoproteinemia.[ncbi.nlm.nih.gov] Leukemia commonly occurring after alkylating agent treatment; manifestations include pancytopenia, megaloblastic bone marrow, and nucleated red cells in peripheral marrow;[icd9data.com]

  • Secondary Myelofibrosis

    These findings are rare and myeloid metaplasia with striking extramedullary hematopoiesis causing massive splenomegaly and mimicking agnogenic myeloid metaplasia is seldom[ncbi.nlm.nih.gov] We concluded that the pancytopenia was because of bone marrow fibrosis resulting from primary hyperparathyroidism.[ncbi.nlm.nih.gov] Thrombocytosis per se, following splenectomy, is not thought to be the major factor predisposing patients to thrombosis.[err.ersjournals.com]

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